Imperial College London
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Dr Simon C. Cork, PhD, FHEA

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7848 8044simon.cork

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rutter:2014:10.1038/ncomms6116,
author = {Rutter, GA and Broichhagen, J and Schönberger, M and Cork, SC and Frank, JA and Marchetti, P and Bugliani, M and Shapiro, AMJ and Trapp, S and Hodson, DJ and Trauner, D},
doi = {10.1038/ncomms6116},
journal = {Nature Communications},
title = {Optical control of insulin release using a photoswitchable sulfonylurea},
url = {http://dx.doi.org/10.1038/ncomms6116},
volume = {5},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Sulfonylureas are widely prescribed for the treatment of type 2 diabetes mellitus (T2DM). Through their actions on ATP-sensitive potassium (KATP) channels, sulfonylureas boost insulin release from the pancreatic beta cell mass to restore glucose homeostasis. A limitation of these compounds is the elevated risk of developing hypoglycemia and cardiovascular disease, both potentially fatal complications. Here, we describe the design and development of a photoswitchable sulfonylurea, JB253, which reversibly and repeatedly blocks KATP channel activity following exposure to violet-blue light. Using in situ imaging and hormone assays, we further show that JB253 bestows light sensitivity upon rodent and human pancreatic beta cell function. Thus, JB253 enables the optical control of insulin release and may offer a valuable research tool for the interrogation of KATP channel function in health and T2DM.
AU  - Rutter,GA
AU  - Broichhagen,J
AU  - Schönberger,M
AU  - Cork,SC
AU  - Frank,JA
AU  - Marchetti,P
AU  - Bugliani,M
AU  - Shapiro,AMJ
AU  - Trapp,S
AU  - Hodson,DJ
AU  - Trauner,D
DO  - 10.1038/ncomms6116
PY  - 2014///
SN  - 2041-1723
TI  - Optical control of insulin release using a photoswitchable sulfonylurea
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/ncomms6116
UR  - http://www.nature.com/ncomms/2014/141014/ncomms6116/full/ncomms6116.html
UR  - http://hdl.handle.net/10044/1/17857
VL  - 5
ER  -
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