Imperial College London


Faculty of MedicineDepartment of Infectious Disease

Honorary Research Fellow



+44 (0)20 7594 3058simon.moore




Sir Alexander Fleming BuildingSouth Kensington Campus






Moore SJ, MacDonald JT, Wienecke S, Kylilis N, Polizzi KM, Biedendieck R and Freemont PS. Prototyping of Bacillus megaterium genetic elements through automated cell-free characterisation and Bayesian modeling. bioRxiv: DOI

Moore SJ, Tosi T, Hleba Y, Bell D, Polizzi KM and Freemont PS. A cell-free synthetic biochemistry platform for raspberry ketone production. bioRxiv: DOI 


Moore SJ, MacDonald JT and Freemont PS (2017). Cell-free synthetic biology for in vitro prototype engineering. Biochem Soc Trans 45: 785

*Moore SJ, Schuchardt C, Deery E, Lawrence AD, Ramos JV, Schnitzer T, Höninger M, Bilig S, Birkemeyer C, Chivers PT, Howard MJ, Rigby SEJ, Layer G and Warren MJ (2017). Elucidation of the biosynthesis of the methane catalyst coenzyme F430. Nature 543:78-82

*Highlighted in the News and Views section of Nature - Begley, TP (2017). Biochemistry: Origin of a key player in methane biosynthesis. Nature 543, 49-50

Moore SJ, Lai HE, Polizzi KM and Freemont PS (2017) Streptomyces venezuelae TX-TL – a next generation cell-free synthetic biology tool. Biotechnol J DOI: 10.1002/biot.201600678

Moore SJ, Lai HE, Kelwich RJR, Chee SM, Bell DJ, Polizzi KM and Freemont PS (2016) EcoFlex: A multifunctional toolkit for E. coli synthetic biology. ACS Synth Biol 5:1059-1069

Kopniczky MB, Moore SJ and Freemont PS (2015) Multilevel regulation and translatonal switches in synthetic biology. IEEE Trans Biomed Circuits Syst 9(4):485-486

Moore SJ, Mayer MJ, Biedendieck R, Deery E and Warren MJ. (2014) Towards a cell factory for vitamin B12 production in Bacillus megaterium: Bypassing of the cobalamin riboswitch control elements. N Biotechnol 31: 553-61 

*Moore SJ, Lawrence AD, Biedendieck R, Deery E, Frank S, Howard MJ, Rigby SE, Warren MJ (2013) Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12). PNAS 110: 14906-14911 

*Highlighted as an invited commentary by PNAS - Dailey HA (2014) Illuminating the black box of B12 biosynthesis. PNAS 110: 14823-14824

Moore SJ, Biedendieck R, Lawrence AD, Deery E, Howard MJ, Rigby SE, Warren MJ (2013) Characterization of the enzyme CbiH60 involved in anaerobic ring contraction of the cobalamin (vitamin B12) biosynthetic pathway. J Biol Chem 288: 297-305

Moore SJ and Warren MJ (2012) The anaerobic biosynthesis of vitamin B12. Biochem Soc Trans 40: 581-586