Publications
246 results found
Murugesu S, Theodorou E, Kasaven LS, et al., 2023, Intrauterine instillation of human chorionic gonadotropin at the time of blastocyst transfer: Systematic review and meta-analysis, JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION, Vol: 52, ISSN: 2468-7847
Jones B, Vali S, Kasaven L, et al., 2023, INvestigational Study Into Transplantation of the Uterus (INSITU); a cross-sectional survey amongst women with uterine factor infertility in the UK assessing background, motivations and suitability, BMJ Open, ISSN: 2044-6055
Importance: The study summarises the selection pre-screen criteria currently used in the UK for a uterus transplant and highlights the number of women who are suitable to proceed. Objectives: To assess the demographics, motivations, reasons and suitability amongst women with AUFI to undergo uterus transplantation (UTx). Design: A cross sectional survey Setting: An electronic questionnaire was sent via email to women with AUFI who had previously been referred to the UTx research team or approached the Womb Transplant UK Charity. The questions assessed suitability to undergo UTx based on demographic information, perceptions to adoption and surrogacy and reasons why UTx was preferable. Responses were assessed against the study selection criteria.Participants: Women with AUFI Results: 210 women completed the questionnaire. The most common aetiology of AUFI in our cohort was MRKH (68%; n=143) whereas 29% (n=62) had previously undergone hysterectomy. 63% (n=132) of the cohort had previously considered adoption, 5% (n=11) had attempted it, and two (1%) had successfully adopted. The most common reason cited to undergo UTx over adoption was to experience gestation (n= 63; 53%), while 37% (n=44) wanted a biologically related child. 76% (n=160) of participants had previously considered surrogacy, 22 (10%) had attempted it and two (1%) had successfully become mothers using a surrogate. The most common reason to undergo UTx over surrogacy was to experience gestation (n=77; 54%). 15% n=21) were concerned about the legal implications, 14% (n=20) identified the financial cost as a barrier and 8% (n=12) could not consider it due to religious reasons. On adhering to the selection criteria, 65 (31%) women were suitable to proceed with the trial.Conclusion: The study demonstrates that implementing commonly used selection criteria for a UTx led to an attrition rate of more than two thirds of women who requested to initially undergo the process. As more studies present outcomes followi
Bergamini A, Ramaswami R, Froeling F, et al., 2023, Fertility outcomes following surgery and multiagent chemotherapy in malignant ovarian germ cell tumor survivors: a survey study., Int J Gynecol Cancer, Vol: 33, Pages: 1750-1756
OBJECTIVE: To assess fertility outcomes in long-term survivors of malignant ovarian germ cell tumors treated with fertility-sparing surgery with or without additional chemotherapy. METHODS: Women diagnosed and treated for malignant ovarian germ cell tumors at Charing Cross Hospital or Mount Vernon Cancer Centre between 1977 and 2015 were included. Questionnaires assessing fertility issues were sent to patients treated with fertility-sparing surgery. Fertility outcomes were evaluated according to the treatment received. The effect of the mean total dose of cyclophosphamide and cisplatin was assessed. RESULTS: A total of 146 patients were sent the questionnaire; 77 (56.5%) patients were included in the analysis. A total of 49 (64%) patients received platinum-based chemotherapy after surgery, 39 (79.6%) of these with cisplatin, vincristine, methotrexate, bleomycin, actinomycin D, cyclophosphamide, and etoposide, while 10 (20.4%) with bleomycin, etoposide, and cisplatin. After any treatment, 39/46 patients (85%) became pregnant: the conception rate was not different between those receiving surgery only and those receiving also chemotherapy (85.7% vs 84.4%, p=1.0). Live birth rate was 80.4% (37/46), with no statistically significant difference between the treatment groups (p=0.42). Median age of women achieving conception was 29 years (IQR 26-33). The probability of live birth at 5 years was 48% and 40% for patients in the surgery only and chemotherapy group, respectively (p=0.55). Infertility and miscarriage rates did not differ significantly between the two treatment groups (p=0.30 and p=0.32). The mean doses of cisplatin and cyclophosphamide received by patients failing and achieving conception were not different (p=0.10, p=0.47). CONCLUSIONS: Our results suggest that fertility may not be hampered in patients with malignant ovarian germ cell tumor treated with fertility-sparing surgery or receiving additional chemotherapy.
Kasaven LS, Mitra A, Ostrysz P, et al., 2023, Exploring the knowledge, attitudes, and perceptions of women of reproductive age towards fertility and elective oocyte cryopreservation for age-related fertility decline in the UK: a cross-sectional survey., Hum Reprod
STUDY QUESTION: What are the knowledge, perceptions and attitudes towards fertility and elective oocyte cryopreservation (OC) for age-related fertility decline (ARFD) in women in the UK? SUMMARY ANSWER: Awareness of OC for ARFD has reportedly improved compared to studies carried out almost a decade ago, but inconsistencies in knowledge remain regarding the rate of miscarriage amongst specific age groups, the financial costs and optimal age to undergo OC for ARFD. WHAT IS KNOWN ALREADY: The age of first-time motherhood has increased amongst western societies, with many women of reproductiveage underestimating the impact of age on fertility. Further understanding of women's awareness of their fertility, the options available to preserve it and the barriers for seeking treatment earlier are required in order to prevent the risk of involuntary childlessness. STUDY DESIGN, SIZE, DURATION: A hyperlink to a cross-sectional survey was posted on social media (Instagram) between 25February 2021 and 11 March 2021. PARTICIPANTS/MATERIALS, SETTING, METHODS: Women from the general population aged 18-50 years were invited to complete the survey. MAIN RESULTS AND THE ROLE OF CHANCE: In total, 5482 women fulfilled the inclusion criteria and completed the survey. The mean age of participants was 35.0 years (SD 10.25; range 16-52). Three quarters (74.1%; n = 4055) disagreed or strongly disagreed they felt well informed regarding the options available to preserve their fertility, in case of a health-related problem or ARFD. The majority overestimated the risk of miscarriage in women aged ≥30 years old, with 14.5% correctly answering 20%, but underestimated the risks in women ≥40, as 20.1% correctly answered 40-50%. Three quarters (73.2%; n = 4007) reported an awareness of OC for ARFD and 65.8% (n = 3605) reported that they would consider undergoing the procedure. The number of women who considered OC for ARFD across a
Kasaven LSS, Marcus D, Theodorou E, et al., 2023, Systematic review and meta-analysis: does pre-implantation genetic testing for aneuploidy at the blastocyst stage improve live birth rate?, JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, Vol: 40, Pages: 2297-2316, ISSN: 1058-0468
Jones BP, Vali S, Saso S, et al., 2023, Living donor uterus transplant in the UK: A case report, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, ISSN: 1470-0328
Vali S, jones B, Saso S, et al., 2023, Attitudes, knowledge, and perceptions amongst women toward uterus transplantation and donation in the UK, Frontiers in Medicine, Vol: 10, Pages: 1-9, ISSN: 2296-858X
Objective: To assess the motivations and perceptions of the general public in the United Kingdom toward donating their uterus for Uterus Transplantation after death (UTx).Design: A cross sectional study.Setting: A 32-item electronic questionnaire.Population: One hundred fifty nine females over the age of 16 living in the United Kingdom, consented and took part in the study.Main outcome measures: The motivations and perceptions toward UTx among the general public including the willingness to donate and barriers preventing donation.Results: One hundred fifty nine women completed the questionnaire. The majority had never heard of UTx (n = 107, 71%) and most were not aware the uterus could be donated after death (n = 130, 92%). 43% of the cohort were willing to donate their uterus after death (n = 57). 8% stated they wished to donate their organs but not their uterus (n = 10). 30% of women (n = 42) believed the child born following UTx would have genetic links to the donor. Over half of the respondents (n = 65, 51%) strongly agreed or agreed they would feel joy in the knowledge that donation would lead to bringing a new life into the world. A quarter of respondents strongly agreed or agreed (n = 45, 25%) that the use of their uterus by another woman would feel like an extension of life.Conclusion: The findings indicate a favorable opinion toward UTx and a positive attitude toward donation of the uterus after death among the general public in the United Kingdom. The findings also highlight the need for education around UTx now this therapeutic option is available.
Barcroft J, Lebbos C, Linton-Reid K, et al., 2023, EP.0248 Automated ultrasound feature extraction in adnexal masses, RCOG World Congress 2023, Publisher: Wiley, Pages: 98-98, ISSN: 1470-0328
Murugesu S, Theodorou E, Kasaven L, et al., 2023, Human chorionic gonadotropin intrauterine instillation at blastocyst transfer: Systematic review and meta-analysis, Publisher: WILEY, Pages: 204-204, ISSN: 1470-0328
Vali S, Jones B, Sheikh S, et al., 2023, How do women in the UK feel about Uterus transplantation and donation?, Publisher: WILEY, Pages: 206-207, ISSN: 1470-0328
Murugesu S, Barcroft J, Elhag B, et al., 2023, Telementoring in gynaecology ultrasound: Impact on patient pathway and postgraduate training, Publisher: WILEY, Pages: 216-217, ISSN: 1470-0328
Murugesu S, Grogan R, Meehan H, et al., 2023, Telemedicine and the impact on postgraduate obstetrics and gynaecology training, Publisher: WILEY, Pages: 216-216, ISSN: 1470-0328
Kasaven L, Saso S, Barcroft J, et al., 2023, An umbrella review of meta-analyses regarding the incidence of female specific malignancies following fertility treatment, Publisher: OXFORD UNIV PRESS, ISSN: 0268-1161
Barcroft J, Pandrich M, Landolfo C, et al., 2023, The classification and management of adnexal masses identified during pregnancy, Publisher: OXFORD UNIV PRESS, ISSN: 0268-1161
Murugesu S, Charalambides MM, Jones BP, et al., 2023, Social egg freezing: Motivations, treatment experiences and the impact of Covid-19-a single-center experience, ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, Vol: 102, Pages: 760-773, ISSN: 0001-6349
Jones B, Vali S, Saso S, et al., 2023, INvestigational Study Into Transplantation of the Uterus (INSITU); Deceased donor uterine retrieval, Publisher: WILEY, Pages: 76-76, ISSN: 1470-0328
Murugesu S, Theodorou E, Kasaven L, et al., 2023, Human chorionic gonadotropin intrauterine instillation at blastocyst transfer: Systematic review and meta-analysis, Publisher: WILEY, Pages: 204-204, ISSN: 1470-0328
Vali S, Jones B, Sheikh S, et al., 2023, How do women in the UK feel about Uterus transplantation and donation?, Publisher: WILEY, Pages: 206-207, ISSN: 1470-0328
Murugesu S, Barcroft J, Elhag B, et al., 2023, Telementoring in gynaecology ultrasound: Impact on patient pathway and postgraduate training, Publisher: WILEY, Pages: 216-217, ISSN: 1470-0328
Barcroft J, Lebbos C, Linton-Reid K, et al., 2023, Automated ultrasound feature extraction in adnexal masses, Publisher: WILEY, Pages: 98-98, ISSN: 1470-0328
Murugesu S, Grogan R, Meehan H, et al., 2023, Telemedicine and the impact on postgraduate obstetrics and gynaecology training, Publisher: WILEY, Pages: 216-216, ISSN: 1470-0328
Jones B, Vali S, Saso S, et al., 2023, INvestigational Study Into Transplantation of the Uterus (INSITU); Deceased donor uterine retrieval, Publisher: WILEY, Pages: 76-76, ISSN: 1470-0328
Bayar E, 2023, Fertility preservation and realignment in transgender women, Human Fertility: an international, multidisciplinary journal dedicated to furthering research and promoting good practice, ISSN: 1464-7273
Medical care for transgender people is multi-faceted and attention to individual reproductiveaspirations and planning are an essential, yet often overlooked aspect of care. Given the impactof hormonal therapy and other gender affirmation procedures on reproductive function, extensivecounselling and consideration of fertility preservation is recommended prior to their commencement.This review article explores the reproductive aspirations of transgender women andconsiders the current disparity between stated desires regarding utilisation of fertility preservationservices. Current fertility preservation options and prospective treatments currently showingpromise in the research arena are explored.
Vali S, Jones BP, Saso S, et al., 2023, The impact of COVID-19 on the motivations of women seeking a uterus transplant, FUTURE SCIENCE OA, Vol: 9, ISSN: 2056-5623
Mitra A, Verbakel JY, Kasaven LS, et al., 2023, The menstrual cycle and the COVID-19 pandemic., PLoS One, Vol: 18
BACKGROUND: The impact of COVID-19 virus on menstrual cycles in unvaccinated women is limited. OBJECTIVE: To investigate the prevalence of changes to menstrual cycle characteristics, hormonal symptoms and lifestyle changes prior to and during the COVID-19 pandemic. METHODS: A retrospective online cross-sectional survey completed by social media users between July 2020 to October 2020. Participants were living in the United Kingdom (UK), premenopausal status and, or over 18 years of age. MAIN OUTCOME(S) AND MEASURES(S): The primary outcome was to assess changes to menstrual cycle characteristics during the pandemic following the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Secondary outcomes included assessment of hormonal and lifestyle changes. RESULTS: 15,611 social media users completed the survey. Of which, 75% of participants experienced a change in their menstrual cycle, with significantly greater proportions reporting irregular menstrual cycles (P<0·001), bleeding duration more than seven days (P<0·001), longer mean cycle length (P<0·001) and overall bleeding duration (P<0·001). Over half the participants reported worsening of premenstrual symptoms including low mood/depression, anxiety and irritability. When stratified according to COVID-19 infection, there was no significant difference in menstrual cycle changes. CONCLUSION: The COVID-19 pandemic resulted in considerable variation in menstrual cycle characteristics and hormonal symptoms. This appears to be related to societal and lifestyle changes resulting from the pandemic, rather than to the virus itself. We believe this may have an impact on the individual, as well as national economy, healthcare, and population levels, and therefore suggest this should be taken into consideration by governments, healthcare providers and employers when developing pandemic recovery plans.
Currie JLD, Saso S, Guerrero K, et al., 2022, Impact of covid-19 on subspecialty training in obstetrics and gynaecology, JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 42, Pages: 3545-3551, ISSN: 0144-3615
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Kasaven LS, Jones BP, Heath C, et al., 2022, Reproductive outcomes from ten years of elective oocyte cryopreservation, ARCHIVES OF GYNECOLOGY AND OBSTETRICS, Vol: 306, Pages: 1753-1760, ISSN: 0932-0067
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L'Heveder A, Chan M, Mitra A, et al., 2022, Sports Obstetrics: Implications of Pregnancy in Elite Sportswomen, a Narrative Review, JOURNAL OF CLINICAL MEDICINE, Vol: 11
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Kasaven LS, Saso S, Getreu N, et al., 2022, Age-related fertility decline: is there a role for elective ovarian tissue cryopreservation?, HUMAN REPRODUCTION, Vol: 37, Pages: 1970-1979, ISSN: 0268-1161
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- Citations: 5
Kasaven L, Jones B, L'Heveder A, et al., 2022, Implications of pregnancy in elite sportswomen, Journal of Clinical Medicine, ISSN: 2077-0383
Increasing numbers of females are participating in elite sport, with a record number having competed at the Tokyo Olympic Games. Importantly, the ages of peak performance and fertility are very likely to coincide, as such, it is inevitable that pregnancy will occur during training andcompetition. Whilst there is considerable evidence to promote regular exercise in pregnancy, withbenefits including a reduction in hypertensive disorders, gestational diabetes and reduced rates ofpost-natal depression, few studies have been conducted which include elite athletes. Indeed, thereare concerns that high-intensity exercise may lead to increased rates of miscarriage and pretermlabour amongst other pregnancy-related complications. There is minimal guidance on the obstetricmanagement of athletes and consequently healthcare professionals frequently adopt a very conservative approach to managing such people. This narrative review summarises the evidence onthe antenatal, intrapartum and postpartum outcomes in elite athletes and provides recommendations for healthcare providers demonstrating that generally, pregnant athletes can continue theirtraining, with a few notable exceptions. It also summarises the physiological changes that occur inpregnancy and reviews the literature base regarding how these changes may impact performance,with benefits arising from pregnancy-associated cardiovascular adaptations at earlier gestations,but later changes causing increased risk of injury and fatigue.
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