Publications
251 results found
Bracewell-Milnes T, Saso S, Nikolaou D, et al., 2018, Investigating the effect of an abnormal cervico-vaginal and endometrial microbiome on assisted reproductive technologies: A systematic review, AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Vol: 80, ISSN: 1046-7408
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- Citations: 32
Lathouras K, Saso S, Tzafetas M, et al., 2018, Genetic polymorphisms of matrix metalloproteinases 1-3 and their inhibitor are not associated with premature labor, FUTURE SCIENCE OA, Vol: 4, ISSN: 2056-5623
Jones BP, Saso S, Smith JR, 2018, Thinking outside the pelvis: cross-fertilisation learning between specialties, OBSTETRICIAN & GYNAECOLOGIST, Vol: 20, Pages: 225-227, ISSN: 1467-2561
Lathouras K, Haidopoulos D, Lever S, et al., 2018, PC/WCC RATIO: A TOOL TO DIFFERENTIATE BETWEEN POSTOPERATIVE SEPSIS AND SPLENECTOMY INDUCED REACTIVE CHANGES AFTER RADICAL SURGERY FOR ADVANCED OR RELAPSED OVARIAN CANCER (OC) ?, Publisher: BMJ PUBLISHING GROUP, Pages: 680-680, ISSN: 1048-891X
Saso S, Tziraki M, Clancy NT, et al., 2018, Use of Laser Speckle Contrast Analysis during pelvic surgery in a uterine transplantation model, Future Science OA, Vol: 4, Pages: FSO324-FSO324, ISSN: 2056-5623
Aim: Uterine transplantation (UTx) is proposed for treatment of uterine factor infertility. Our aim was to assess whether Endoscopic Laser Speckle Contrast Analysis (eLASCA) could evaluate pelvic blood flow at anastomotic sites required for sheep and rabbit UTx. Results/methodology: eLASCA detected blood flow in rabbit UTx #7 and #9. In sheep UTx #2, #3 and #5, the results allowed us to conclude that blood flow was present in the uterine graft following transplantation; and post-UTx, the animal had heart and respiratory rates, and oxygen saturation compatible with a normal hemodynamic status. Conclusion: These preliminary results establish the potential of Laser Speckle Contrast Analysis as noncontact and real-time tool for observation of spatially-resolved blood flow from which other parameters can be derived.
Al-Memar M, Bobdiwala S, Madhra M, et al., 2018, The potential value of activin B and fibronectin for the triage of pregnancies of unknown location and prediction of first trimester viability., Australasian Journal of Ultrasound Medicine, Vol: 21, Pages: 138-146, ISSN: 1441-6891
Aim: We have assessed the potential predictive ability of the biomarkers activin B and fibronectin (FN1) alone and when added to established markers for triaging patients as being at low or high risk of ectopic pregnancy (EP). We also assessed their use as predictors of viability at 12 weeks gestation. Methods: Exploratory secondary analysis of a prospective study including all women classified as a pregnancy of known location (PUL) based on transvaginal ultrasonography between January and December 2007 at the early pregnancy unit of St Georges' Hospital (London). We used multinomial logistic regression to assess the diagnostic potential of the biomarkers to triage PUL at high risk of complications (EP or persistent PUL), and standard binary logistic regression to predict first trimester viability at 12 weeks. Results: For discriminating high-risk (n = 16) from low-risk PUL (n = 93), the area under the receiver operating characteristic curve (AUC) was 0.75 (95% confidence interval 0.60-0.85) for activin B and 0.55 (0.41-0.68) for FN1. Adding activin B to a multinomial logistic regression model incorporating β-hCG ratio and initial progesterone yielded odds ratios of 0.16 (0.05-0.55) for failing vs high-risk PUL and 0.29 (0.07-1.19) for intrauterine vs high-risk PUL and increased the model's AUC from 0.84 to 0.89. At a risk threshold of 5% for high-risk PUL, sensitivity increased from 84% to 87% and specificity from 48% to 64%. For discriminating viable (n = 28) from non-viable (n = 81) pregnancies at 12 weeks, both markers had an AUC of 0.54. Conclusions: Our results suggested that activin B may be a promising marker to improve PUL triage in addition to established markers.
Jones BP, Saso S, Mania A, et al., 2018, The dawn of a new ice age: social egg freezing, ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, Vol: 97, Pages: 641-647, ISSN: 0001-6349
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- Citations: 25
Saso S, Clancy NT, Jones BP, et al., 2018, Use of biomedical photonics in gynecological surgery: a uterine transplantation model, Future Science OA, Vol: 4, Pages: FSO286-FSO286, ISSN: 2056-5623
Aim: Uterine transplantation (UTx) has been proposed as a treatment for permanent absolute uterine factor infertility. The study aims were to compare pulse oximetry and multispectral imaging (MSI), for intraoperative tracking of uterine oxygen saturation in animal UTx models (rabbit and sheep). Results/methodology: Imaging results confirmed the re-establishment of adequate perfusion in the transplanted organ after surgery. Comparison of oxygen saturation values between the pre-UTx donor and post-UTx recipient, and pre-UTx and post-UTx recipient reveals a statistically significant decrease in saturation levels post-UTx. Conclusion: The use of MSI is the first case in gynecology and has demonstrated promise of possible future human use. MSI technique has advantages over pulse oximetry - it provides spatial information in a real-time, noncontact manner.
Bracewell-Milnes T, Saso S, Abdalla H, et al., 2018, A systematic review investigating psychosocial aspects of egg sharing in the United Kingdom and their potential effects on egg donation numbers, HUMAN FERTILITY, Vol: 21, Pages: 163-173, ISSN: 1464-7273
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- Citations: 16
Jones BP, Saso S, Farren J, et al., 2017, Ultrasound-Guided Laparoscopic Ovarian Wedge Resection in Recurrent Serous Borderline Ovarian Tumours, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 27, Pages: 1813-1818, ISSN: 1048-891X
Bracewell-Milnes T, Saso S, Abdalla H, et al., 2017, Metabolomics as a tool to identify biomarkers to predict and improve outcomes in reproductive medicine: a systematic review, Human Reproduction Update, Vol: 23, Pages: 723-736, ISSN: 1355-4786
BACKGROUNDInfertility is a complex disorder with significant medical, psychological and financial consequences for patients. With live-birth rates per cycle below 30% and a drive from the Human Fertilisation and Embryology Authority (HFEA) to encourage single embryo transfer, there is significant research in different areas aiming to improve success rates of fertility treatments. One such area is investigating the causes of infertility at a molecular level, and metabolomics techniques provide a platform for studying relevant biofluids in the reproductive tract.OBJECTIVE AND RATIONALEThe aim of this systematic review is to examine the recent findings for the potential application of metabolomics to female reproduction, specifically to the metabolomics of follicular fluid (FF), embryo culture medium (ECM) and endometrial fluid. To our knowledge no other systematic review has investigated this topic.SEARCH METHODSEnglish peer-reviewed journals on PubMed, Science Direct, SciFinder, were systematically searched for studies investigating metabolomics and the female reproductive tract with no time restriction set for publications. Studies were assessed for quality using the risk of bias assessment and ROBIN-I.OUTCOMESThere were 21 studies that met the inclusion criteria and were included in the systematic review. Metabolomic studies have been employed for the compositional analysis of various biofluids in the female reproductive tract, including FF, ECM, blastocoele fluid and endometrial fluid. There is some weak evidence that metabolomics technologies studying ECM might be able to predict the viability of individual embryos and implantation rate better than standard embryo morphology, However these data were not supported by randomized the controlled trials (RCTs) which showed no evidence that using metabolomics is able to improve the most important reproductive outcomes, such as clinical pregnancy and live-birth rates. This systematic review provides guidance for future
Murugesu S, Saso S, Jones BP, et al., 2017, Does the use of calcium ionophore during artificial oocyte activation demonstrate an effect on pregnancy rate? A meta-analysis, FERTILITY AND STERILITY, Vol: 108, Pages: 468-+, ISSN: 0015-0282
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- Citations: 36
Al-Memar M, Saso S, Bobdiwala S, et al., 2017, Validation of a virtual reality simulator for the use of transvaginal ultrasonography in gynaecology and early pregnancy., Australas J Ultrasound Med, Vol: 20, Pages: 97-105, ISSN: 1836-6864
Introduction: The objective was to validate a virtual reality simulation ultrasound model as a tool for training in the use of transvaginal ultrasonography in gynaecology and early pregnancy. Methods: Three separate groups consisting of novice and intermediate level residents as well as expert ultrasound examiners were recruited to the study. All were asked to answer a questionnaire regarding demographic data and ultrasound experience. They subsequently completed two modules: basic gynaecology and early pregnancy, followed by corresponding assessments using a high-fidelity simulator (Scantrainer; Medaphor™, Cardiff, UK). Finally, the expert group completed an additional questionnaire about various elements of the simulator using a 5-point Likert scale. Results: Each group consisted of eight participants. Overall, the participants agreed that simulation played a role in training (Novices: 75% (n = 6); Intermediates: 100% (n = 8); Experts: 75% (n = 6)). For the degree of realism of the target objects in the gynaecology and early pregnancy module environments compared to a real-patient environment, the simulator was rated satisfactory or very satisfactory by 88% (n = 7) and 75% (n = 6) of experts, respectively. All experts rated the overall usefulness of the content of the simulator for learning fundamental ultrasound technical skills compared to current training methods to be at least satisfactory. When reviewing the assessment scores, experts scored higher than non-experts in gynaecology (P = 0.002) and early pregnancy modules (P = 0.03). Discussion: Face, content and construct validity were demonstrated by the virtual reality ultrasound simulator, suggesting it may be an effective method for training ultrasound skills in gynaecology and early pregnancy to non-expert residents.
Saso S, Jones BP, Bracewell-Milnes T, et al., 2017, Gynecological cancers: an alternative approach to healing., Future Sci OA, Vol: 3, ISSN: 2056-5623
Grief and hope are two conflicting emotions that a patient recently diagnosed with cancer has to master. The real challenge for gynecologic oncologists is how to reach out. Conventional wisdom states that offering patients focus and belief when combating cancer in their lives allows them to embrace hope with greater confidence, which minimizes their grief. Three pictorial models are presented: '4-cusp approach' model used at the initial consultation; 'tapestry of bereavement or landscape of grief' model at the postsurgery consultation; and 'Venn-diagram' model at any time during patient management. We have applied these models in our practice and believe that they can act as a fulcrum for the patient, the family and healthcare team around which therapy should be centered.
Jalmbrant M, Jones B, Saso S, et al., 2017, Developing a psychological screening protocol for the UK uterine transplant trial, Publisher: WILEY, Pages: 10-10, ISSN: 1470-0328
Jalmbrant M, Jones B, Saso S, et al., 2017, A survey of the psychological attributes of women waiting for uterus transplants: General and fertility-specific quality of life and psychological distress, Publisher: WILEY, Pages: 10-11, ISSN: 1470-0328
Jones BP, Rees R, Saso S, et al., 2017, Ultrasound-guided laparoscopic ovarian preserving surgery to treat anti-NMDA receptor encephalitis, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 124, Pages: 337-341, ISSN: 1470-0328
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- Citations: 11
Al-Memar M, Caccitore S, Bobdiwala S, et al., 2016, Urine metabolomic changes by gestational age in early pregnancy and differences in the metabolome in viable pregnancies that miscarry compared to those that remain viable, Publisher: WILEY-BLACKWELL, Pages: E1-E1, ISSN: 1470-0328
Jones BP, Saso S, Farren J, et al., 2016, Intraoperative ultrasound-guided laparoscopic ovarian-tissue-preserving surgery for recurrent borderline ovarian tumor., Ultrasound in Obstetrics and Gynecology, Vol: 50, Pages: 405-406, ISSN: 0960-7692
Rockall AG, Qureshi M, Papadopoulou I, et al., 2016, Role of Imaging in Fertility-sparing Treatment of Gynecologic Malignancies, RADIOGRAPHICS, Vol: 36, Pages: 2214-2233, ISSN: 0271-5333
Clancy NT, Saso S, Stoyanov D, et al., 2016, Multispectral imaging of organ viability during uterine transplantation surgery in rabbits and sheep., Journal of Biomedical Optics, Vol: 21, ISSN: 1083-3668
Uterine transplantation surgery (UTx) has been proposed as a treatment for permanent absolute uterine factor infertility (AUFI) in the case of the congenital absence or surgical removal of the uterus. Successful surgical attachment of the organ and its associated vasculature is essential for the organ’s reperfusion and long-term viability. Spectral imaging techniques have demonstrated the potential for the measurement of hemodynamics in medical applications. These involve the measurement of reflectance spectra by acquiring images of the tissue in different wavebands. Measures of tissue constituents at each pixel can then be extracted from these spectra through modeling of the light–tissue interaction. A multispectral imaging (MSI) laparoscope was used in sheep and rabbit UTx models to study short- and long-term changes in oxygen saturation following surgery. The whole organ was imaged in the donor and recipient animals in parallel with point measurements from a pulse oximeter. Imaging results confirmed the re-establishment of adequate perfusion in the transplanted organ after surgery. Cornual oxygenation trends measured with MSI are consistent with pulse oximeter readings, showing decreased StO2 immediately after anastomosis of the blood vessels. Long-term results show recovery of StO2 to preoperative levels.
Al-Memar M, Bobdiwala S, Nikolic G, et al., 2016, EP25.02: Does pregnancy outcome in the first trimester correlate with the amount of vaginal bleeding and pain? A preliminary study., Ultrasound Obstet Gynecol, Vol: 48 Suppl 1, Pages: 371-372
Saso S, Jones B, Yazbek J, 2016, Abstracts of the 26th World Congress on Ultrasound in Obstetrics and Gynecology, Rome, Italy, 24-28 September 2016., Ultrasound Obstet Gynecol, Vol: 48 Suppl 1
Sayasneh A, Ferrara L, De Cock B, et al., 2016, Evaluating the risk of ovarian cancer before surgery using the ADNEX model: a multicentre external validation study, British Journal of Cancer, Vol: 115, Pages: 542-548, ISSN: 1532-1827
BACKGROUND: The International Ovarian Tumour Analysis (IOTA) group have developed the ADNEX (The Assessment of Different NEoplasias in the adneXa) model to predict the risk that an ovarian mass is benign, borderline, stage I, stages II-IV or metastatic. We aimed to externally validate the ADNEX model in the hands of examiners with varied training and experience. METHODS: This was a multicentre cross-sectional cohort study for diagnostic accuracy. Patients were recruited from three cancer centres in Europe. Patients who underwent transvaginal ultrasonography and had a histological diagnosis of surgically removed tissue were included. The diagnostic performance of the ADNEX model with and without the use of CA125 as a predictor was calculated. RESULTS: Data from 610 women were analysed. The overall prevalence of malignancy was 30%. The area under the receiver operator curve (AUC) for the ADNEX diagnostic performance to differentiate between benign and malignant masses was 0.937 (95% CI: 0.915-0.954) when CA125 was included, and 0.925 (95% CI: 0.902-0.943) when CA125 was excluded. The calibration plots suggest good correspondence between the total predicted risk of malignancy and the observed proportion of malignancies. The model showed good discrimination between the different subtypes. CONCLUSIONS: The performance of the ADNEX model retains its performance on external validation in the hands of ultrasound examiners with varied training and experience.British Journal of Cancer advance online publication, 2 August 2016; doi:10.1038/bjc.2016.227 www.bjcancer.com.
Saso S, Jones B, Clancy N, et al., 2016, Imaging of organ viability during deep pelvic surgery: The use of biomedical photonics to assess uterine perfusion and vessel integrity in uterine transplantation models, Publisher: Wiley, Pages: 20-20, ISSN: 1471-0528
Al-Memar M, Cacciatore S, Bobdiwala S, et al., 2016, Urine metabolomic changes by gestational age in early pregnancy and differences in the metabolome in viable pregnancies that miscarry compared to those that remain viable, Publisher: Wiley, Pages: 76-76, ISSN: 1470-0328
Saso S, Jones B, Yazbek J, et al., 2016, Uterine transplantation in the UK: The move from the animal model into the human setting - surgical, reproductive and clinical aspects, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 123, Pages: 71-71, ISSN: 1470-0328
Jones B, Rees R, Saso S, et al., 2016, Successful treatment of anti-NMDA receptor encephalitis using ovarian preserving ultrasound guided ovarian wedge resection, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 123, Pages: 22-23, ISSN: 1470-0328
Jones B, Jeevananthan P, Sayasneh A, et al., 2016, The novel application of plasma energy as a tissue preserving treatment modality for vulval and perianal intraepithelial neoplasia, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 123, Pages: 81-81, ISSN: 1470-0328
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- Citations: 1
Saso S, Jones B, Bracewell-Milnes T, et al., 2016, Psychological issues associated with absolute uterine factor infertility and attitudes of patients towards uterine factor infertility and uterine transplantation: A face-to-face consultation, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 123, Pages: 40-41, ISSN: 1470-0328
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