Imperial College London
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Mr SRDJAN SASO

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)7890 795 182srdjan.saso01

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kasaven:2022:10.3390/cancers14061485,
author = {Kasaven, L and Chawla, M and Jones, B and Al-, Memar M and Galazis, N and Ahmed-Salim, Y and El-Bahrawy, M and Lavery, S and Saso, S and Yazbek, J},
doi = {10.3390/cancers14061485},
journal = {Cancers},
title = {Fertility sparing surgery and borderline ovarian tumours},
url = {http://dx.doi.org/10.3390/cancers14061485},
volume = {14},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - o determine the oncological outcomes following fertility-sparing surgery (FSS) for the management of Borderline Ovarian Tumours (BOTs). A retrospective analysis of participants diagnosed with BOTs between January 2004 and December 2020 at the West London Gynaecological Oncology Centre was conducted. A total of 172 women were diagnosed; 52.3% (90/172) underwent FSS and 47.7% (82/172) non-FSS. The overall recurrence rate of disease was 16.9% (29/172), of which 79.3% (23/29) presented as the recurrence of serous or sero-mucinous BOTs and 20.7% (6/29) as low-grade serous carcinoma (LGSC). In the FSS group, the recurrence rate of BOTs was 25.6% (23/90) presenting a median 44.0 (interquartile range (IQR) 41.5) months, of which there were no episodes of recurrence presenting as LGSC reported. In the non-FSS group, all recurrences of disease presented as LGSC, with a rate of 7.7% (6/78), following a median of 47.5 months (IQR 47.8). A significant difference between the type of surgery performed (FSS v Non-FSS) and the association with recurrence of BOT was observed (Pearson Chi-Square: p = 0.000; x = 20.613). Twelve women underwent ultrasound-guided ovarian wedge resection (UGOWR) as a novel method of FSS. Recurrence of BOT was not significantly associated with the type of FSS performed (Pearson Chi- Square: x = 3.166, p = 0.379). Non-FSS is associated with negative oncological outcomes compared to FSS, as evidenced by the higher rate of recurrence of LGSC. This may be attributed to the indefinite long-term follow up with ultrasound surveillance all FSS women undergo, enabling earlier detection and treatment of recurrences.
AU  - Kasaven,L
AU  - Chawla,M
AU  - Jones,B
AU  - Al-,Memar M
AU  - Galazis,N
AU  - Ahmed-Salim,Y
AU  - El-Bahrawy,M
AU  - Lavery,S
AU  - Saso,S
AU  - Yazbek,J
DO  - 10.3390/cancers14061485
PY  - 2022///
SN  - 2072-6694
TI  - Fertility sparing surgery and borderline ovarian tumours
T2  - Cancers
UR  - http://dx.doi.org/10.3390/cancers14061485
UR  - http://hdl.handle.net/10044/1/96028
VL  - 14
ER  -
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