Imperial College London
Alternate

Emeritus ProfessorRichardUnderwood

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Cardiac Imaging
 
 
 
//

Contact

 

+44 (0)20 7351 8811srunderwood

 
 
//

Location

 

2.30Britten WingRoyal Brompton Campus

//

Summary

 

Publications

Citation

BibTex format

@article{van:2020:10.1016/j.jcct.2019.06.007,
author = {van, Diemen PA and Driessen, RS and Stuijfzand, WJ and Raijmakers, PG and Schumacher, SP and Bom, MJ and Everaars, H and Min, JK and Leipsic, JA and Knuuti, J and Underwood, SR and van, de Ven PM and van, Rossum AC and Danad, I and Knaapen, P},
doi = {10.1016/j.jcct.2019.06.007},
journal = {Journal of Cardiovascular Computed Tomography},
pages = {60--67},
title = {Impact of scan quality on the diagnostic performance of CCTA, SPECT, and PET for diagnosing myocardial ischemia defined by fractional flow reserve},
url = {http://dx.doi.org/10.1016/j.jcct.2019.06.007},
volume = {14},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundScan quality can have a significant effect on the diagnostic performance of non-invasive imaging techniques. However, the extent of its influence has scarcely been investigated in a head-to-head manner.MethodsTwo-hundred and eight patients underwent CCTA, SPECT, and PET prior to invasive fractional flow reserve measurements. Scan quality was classified as either good, moderate, or poor.ResultsDistribution of good, moderate, and poor quality scans was; CCTA; 66%, 22%, 13%; SPECT; 52%, 38%, 9%; PET; 86%, 13%, 1%. Good quality CCTA scans possessed a higher specificity (75% vs. 31%, p=0.001), positive predictive value (PPV, 71% vs. 51%, p=0.050), and accuracy (80% vs. 60%, p=0.009) compared to moderate quality scans, while sensitivity (94%) and negative predictive value (NPV, 88%) were similar to moderate and poor quality scans. Sensitivity (76%), NPV (84%), and accuracy (85%) of good quality SPECT scans was superior to those of moderate (41% p=0.001, 56% p=0.010, 70% p=0.010) and poor quality (30% p=0.003, 65% p=0.069, 63% p=0.038). Specificity (92%) and PPV (87%) of good quality SPECT scans did not differ from scans of diminished quality. Good quality PET scans exhibited high sensitivity (84%), specificity (86%), NPV (88%), PPV (81%) and accuracy (85%), which was comparable to scans of lesser quality. Good quality CCTA, SPECT, and PET scans demonstrated a similar diagnostic accuracy (p=0.247).ConclusionDiagnostic performance of CCTA, and SPECT is hampered by scan quality, while the diagnostic value of PET is not affected. Good quality CCTA, SPECT, and PET scans possess a high diagnostic accuracy.
AU  - van,Diemen PA
AU  - Driessen,RS
AU  - Stuijfzand,WJ
AU  - Raijmakers,PG
AU  - Schumacher,SP
AU  - Bom,MJ
AU  - Everaars,H
AU  - Min,JK
AU  - Leipsic,JA
AU  - Knuuti,J
AU  - Underwood,SR
AU  - van,de Ven PM
AU  - van,Rossum AC
AU  - Danad,I
AU  - Knaapen,P
DO  - 10.1016/j.jcct.2019.06.007
EP  - 67
PY  - 2020///
SN  - 1934-5925
SP  - 60
TI  - Impact of scan quality on the diagnostic performance of CCTA, SPECT, and PET for diagnosing myocardial ischemia defined by fractional flow reserve
T2  - Journal of Cardiovascular Computed Tomography
UR  - http://dx.doi.org/10.1016/j.jcct.2019.06.007
UR  - http://hdl.handle.net/10044/1/72022
VL  - 14
ER  -
Download