Imperial College London
Alternate

ProfessorStephenBrett

Faculty of Medicine, Department of Surgery & Cancer

Professor of Critical Care
 
 
 
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Contact

 

+44 (0)20 3313 4521stephen.brett Website

 
 
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Location

 

Hammersmith House 570Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Look:2022:10.1016/j.resuscitation.2021.10.005,
author = {Look, N and Voss, S and Blennow, Nordström E and Brett, S and Jenkinson, E and Shaw, P and White, P and Benger, J},
doi = {10.1016/j.resuscitation.2021.10.005},
journal = {Resuscitation},
pages = {238--246},
title = {Neurocognitive function following out-of-hospital cardiac arrest: a systematic review},
url = {http://dx.doi.org/10.1016/j.resuscitation.2021.10.005},
volume = {170},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectivesThe primary aim of this review was to investigate neurocognitive outcomes following out-of-hospital cardiac arrest (OHCA). Specifically, the focus was on identifying the different neurocognitive domains that are assessed, the measures used, and the level of, and criteria for, impairment.Design and review methodsA systematic review of the literature from 2006 to 2021 was completed using Medline, Cinahl and Psychinfo. Criteria for inclusion were studies with participants over the age of 18, OHCA and at least one neurocognitive function measure. Qualitative and case studies were excluded. Reviewers assessed criteria and risk of bias using a modified version of Downs and Black.ResultsForty-three studies were identified. Most studies had a low risk of bias (n = 31) or moderate risk of bias (n = 11) and one had a high risk; however, only six reported effect sizes or power analyses. Multiple measures of neurocognitive outcomes were used (>50) and level of impairment criteria varied considerably. Memory impairments were frequently found and were also more likely to be impaired followed by executive function and processing speed.DiscussionThis review highlights the heterogeneity of measures and approaches used to assess neurocognitive outcomes following OHCA as well as the need to improve risk of bias concerning generalizability. Improved understanding of the approaches used for assessment and the subsequent findings will facilitate a standardized evaluation of neurocognitive outcomes following OHCA.
AU  - Look,N
AU  - Voss,S
AU  - Blennow,Nordström E
AU  - Brett,S
AU  - Jenkinson,E
AU  - Shaw,P
AU  - White,P
AU  - Benger,J
DO  - 10.1016/j.resuscitation.2021.10.005
EP  - 246
PY  - 2022///
SN  - 0300-9572
SP  - 238
TI  - Neurocognitive function following out-of-hospital cardiac arrest: a systematic review
T2  - Resuscitation
UR  - http://dx.doi.org/10.1016/j.resuscitation.2021.10.005
UR  - https://www.sciencedirect.com/science/article/pii/S0300957221004019?via%3Dihub
UR  - http://hdl.handle.net/10044/1/92589
VL  - 170
ER  -
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