Professor Stuart D Rosen

Rosen SD, Paulesu E, Wise RLS, Camici PGet al., 2002, Central neural contribution to the perception of chest pain in cardiac syndrome X, HEART, Vol: 87, Pages: 513-519, ISSN: 1355-6037

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• Citations: 83

Guzzetti S, Spyrou N, Rosen SD, Mezzetti S, Martinoli E, Foale RA, Camici PGet al., 2002, Low frequency spectral component of heart rate variability and myocardial beta-adrenoceptor density after acute myocardial infarction, BASIC RESEARCH IN CARDIOLOGY, Vol: 97, Pages: 97-104, ISSN: 0300-8428

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• Citations: 13

Rosen SD, Levene S, 2002, Medicolegal sketch - GPIIb/IIIa inhibitors, nicely sidelined?, CME Cardiol, Vol: 2, Pages: 72-74, ISSN: 1463-0486

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Rosen SD, 2002, Left ventricular aneurysm formation after acute myocardial infarction, Int J Cardiol, Vol: 82, Pages: 14-16, ISSN: 0167-5273

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Rosen SD, 2001, The pathophysiology of cardiac syndrome X - a tale of paradigm shifts, CARDIOVASCULAR RESEARCH, Vol: 52, Pages: 174-177, ISSN: 0008-6363

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• Citations: 11

Rosen SD, Murphy K, Leff A, Adams L, Camici PGet al., 2001, Altered central nervous system processing in patients with heart failure: A study with positron emission tomography, CIRCULATION, Vol: 104, Pages: 365-366, ISSN: 0009-7322

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Rosen SD, Murphy K, Leff A, Adams L, Camici PGet al., 2001, The role of the central nervous system in the perception of dyspnoea in patients with heart failure, EUROPEAN HEART JOURNAL, Vol: 22, Pages: 296-296, ISSN: 0195-668X

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Spyrou N, Khan MA, Rosen SD, Foale R, Davies DW, Sogliani F, Camici R, De Lisle Stanbridge R, Camici PGet al., 2001, Erratum: Persistent but reversible coronary microvascular dysfunction after bypass grafting (American Journal of Physiology - Heart and Circulatory Physiology (December 2000) 279 (H2634-H2640)), American Journal of Physiology - Heart and Circulatory Physiology, Vol: 280, ISSN: 0363-6135

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Spyrou N, Khan MA, Rosen SD, Jagathesan R, Foale R, Davies DW, Sogliani F, Stanbridge RD, Camici PGet al., 2001, Persistent but reversible coronary microvascular dysfunction after bypass grafting (vol 279, pg H2634, 2000), AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 280, Pages: HA1-HA1, ISSN: 0363-6135

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Spyrou N, Khan MA, Rosen SD, Foale R, Davies DW, Sogliani F, Stanbridge RD, Camici PGet al., 2000, Persistent but reversible coronary microvascular dysfunction after bypass grafting, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 279, Pages: H2634-H2640, ISSN: 0363-6135

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• Citations: 30

Banzett RB, Mulnier HE, Murphy K, Rosen SD, Wise RJS, Adams Let al., 2000, Breathlessness in humans activates insular cortex, NEUROREPORT, Vol: 11, Pages: 2117-2120, ISSN: 0959-4965

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• Citations: 245

Rosen SD, Camici PG, 2000, The brain-heart axis in the perception of cardiac pain: the elusive link between ischaemia and pain, ANNALS OF MEDICINE, Vol: 32, Pages: 350-364, ISSN: 0785-3890

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• Citations: 29

Rosen SD, Camici PG, 2000, Endothelium-dependent and -independent perfusion reserve and the effect of L-arginine on myocardial perfusion in patients with syndrome X., Circulation, Vol: 101, Pages: E205-E206

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Rosen SD, Camici PG, 2000, Endothelium-dependent and -independent perfusion reserve and the effect of L-arginine on myocardial perfusion in patients with syndrome X, CIRCULATION, Vol: 101, Pages: E205-E205, ISSN: 0009-7322

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Banzett RB, Mulnier HE, Murphy K, Rosen SD, Wise R, Adams Let al., 2000, PET shows anterior insular cortex activated with air hunger in healthy humans, FASEB JOURNAL, Vol: 14, Pages: A646-A646, ISSN: 0892-6638

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Adams L, Mulnier HE, Murphy K, Rosen SD, Wise R, Banzett RBet al., 2000, PET shows posterior insular cortex activated with increased tidal volume in healthy humans, FASEB JOURNAL, Vol: 14, Pages: A646-A646, ISSN: 0892-6638

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Rimoldi O, Burns SM, Rosen SD, Wistow TE, Schofield PM, Taylor G, Camici PGet al., 1999, Measurement of myocardial blood flow with positron emission tomography before and after transmyocardial laser revascularization, CIRCULATION, Vol: 100, Pages: 134-138, ISSN: 0009-7322

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• Citations: 34

Rosen SD, Lorenzoni R, Kaski JC, Foale RA, Camici PGet al., 1999, Effect of α₁-adrenoceptor blockade on coronary vasodilator reserve in cardiac syndrome X, JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, Vol: 34, Pages: 554-560, ISSN: 0160-2446

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• Citations: 13

de Jong RM, Rhodes CG, Anthonio RL, Willemsen ATM, Blanksma PK, Lammertsma AA, Rosen SD, Vaalburg W, Crijns HJGM, Camici PGet al., 1999, Parametric polar maps of regional myocardial β-adrenoceptor density, JOURNAL OF NUCLEAR MEDICINE, Vol: 40, Pages: 507-512, ISSN: 0161-5505

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• Citations: 6

Boyd HL, Rosen SD, Rimoldi O, Cunningham VJ, Camici PGet al., 1998, Normal values for left ventricular volumes obtained using gated PET., G Ital Cardiol, Vol: 28, Pages: 1207-1214, ISSN: 0046-5968

BACKGROUND: Accurate assessment of left ventricular (LV) volumes provides important insights into myocardial function, being particularly important for diseases of the heart in which there is progressive dilatation of the LV, such as remodeling after myocardial infarction. We have recently validated a method for measuring LV volumes using gated positron emission tomography (PET) with oxygen-15 labeled carbon monoxide (C15O). The present study was performed to establish normal values for LV volumes, in absolute units, using this technique. METHODS: Forty subjects [21 males and 19 females; age 49 +/- 13 years (mean +/- SD), range 24-80; body surface area (BSA) range 1.50-2.18 m2] were studied. End diastolic (EDV) and end systolic volumes (ESV) were calculated by determining the edge of the end diastolic and end systolic blood pool images (obtained using PET with C15O) and summing the volume of the voxels comprising the blood pool. RESULTS: For the overall study population, EDV was 109 +/- 20 ml and ESV 37 +/- 12 ml. When stratified according to gender, these values were: in males, EDV was 117 +/- 18 ml and ESV 42 +/- 18 ml; in females, EDV was 100 +/- 19 ml and ESV 32 +/- 8 ml. The differences between gender groups (EDV: p = 0.0027, ESV: p = 0.0029) were eliminated when volumes were corrected for BSA. CONCLUSIONS: These data will form a database of normal values for comparison with pathological conditions of the heart. PET quantification of LV volumes offers a means of measurement of function using an imaging modality that can also assess regional myocardial perfusion and metabolism during the same study session.

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Bistrup A, Bakhta S, Tangemann K, Lee JK, Gunn MD, Belov YY, Kannagi R, Hemmerich S, Rosen SDet al., 1998, Cloning and characterization of a human glycosyl sulfotransferase that is restricted to high endothelial venules and confers expression of the L-selectin recognition epitope 6-sulfo sialyl Lewis X., Publisher: AMER SOC CELL BIOLOGY, Pages: 124A-124A, ISSN: 1059-1524

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• Citations: 1

Sassetti CM, Rosen SD, 1998, Identification of a novel member of the CD34/podocalyxin family of endothelial mucins., Publisher: AMER SOC CELL BIOLOGY, Pages: 121A-121A, ISSN: 1059-1524

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Rosen SD, Paulesu E, Wise RJS, Tousoulis D, Camici PGet al., 1998, Cardiac syndrome X: a model of chronic visceral pain of cortical origin, CIRCULATION, Vol: 98, Pages: 850-850, ISSN: 0009-7322

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• Citations: 2

Rimoldi O, Burns SM, Rosen SD, Schofield PM, Camici PGet al., 1998, Measurements of myocardial blood flow with positron emission tomography before and after transmyocardial revascularization., CIRCULATION, Vol: 98, Pages: 407-407, ISSN: 0009-7322

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• Citations: 4

Lorenzoni R, Pagano D, Mazzotta G, Rosen SD, Fattore G, De Caterina R, Gensini Get al., 1998, Pitfalls in the economic evaluation of thrombolysis in myocardial infarction - The impact of national differences in the cost of thrombolytics and of differences in the efficacy across patient subgroups, EUROPEAN HEART JOURNAL, Vol: 19, Pages: 1518-1524, ISSN: 0195-668X

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• Citations: 10

Tousoulis D, Davies G, Crake T, Lefroy DC, Rosen S, Maseri Aet al., 1998, Angiographic characteristics of infarct-related and non-infarct-related stenoses in patients in whom stable angina progressed to acute myocardial infarction, AMERICAN HEART JOURNAL, Vol: 136, Pages: 382-388, ISSN: 0002-8703

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• Citations: 19

Hermansen F, Rosen SD, Fath-Ordoubadi F, Kooner JS, Clark JC, Camici PG, Lammertsma AAet al., 1998, Measurement of myocardial blood flow with oxygen-15 labelled water: comparison of different administration protocols, EUROPEAN JOURNAL OF NUCLEAR MEDICINE, Vol: 25, Pages: 751-759, ISSN: 0340-6997

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• Citations: 93

Spyrou N, Rosen SD, Foale RA, Davies WD, Camici PGet al., 1998, Myocardial β-adrenoceptor density 1 month after myocardial infarction predicts left ventricular remodelling, Heart, Vol: 79, ISSN: 1355-6037

Following acute myocardial infarction (AMI) there is evidence of sustained sympathetic overactivity. This has been shown to contribute to left ventricular (LV) remodelling in animals. Increased tissue levels of noradrenaline lead to a reduction of β-adrenoceptor (βAR) density, which can be measured non invasively with positron emission tomography (PET). The aim of this study was to assess 1- if there is a reduction of myocardial βAR density 1 month after AMI and 2- if this βAR density correlates with changes in LV volumes at 6 months. We studied 42 patients (mean age 53±12 years) who suffered AMI. They had no previous angina, diabetes, hypertension or renal disease and all had single vessel disease. LV end systolic (ESV) and end diastolic (EDV) volumes were determined at 1 week and 6 months after AMI using echocardiography. Changes (d) in ESV and EDV were calculated by dividing the 6 month by the 1 week result. Myocardial βAR density and the coronary vasodilator reserve (CVR, dipyridamole) were measured 1 month after AMI using PET with 11CGP 12177 and H215O respectively. Results: The average ESV at 1 week was 61±20 ml compared to 64±28 ml at 6 months (p=ns) while the respective EDV values were 111±31 and 121±40 ml (p=ns). The patients had significantly reduced βAR density (5.95±0.99 pmol/g) compared to controls (8.35±2.00 pmol/g, p=0.0001). The CVR was also lower in patients (1.81±0.75) compared to controls (3.22±1.19, p=0.0001). In patients there was a significant correlation between lower βAR and higher dEDV (r=0.42, p=0.006). There was a significant correlation between lower CVR and higher dESV (r=0.33, p=0.04) and dEDV (r=0.98, p=0.05). Conclusion: 1. We have shown a significant reduction in βAR density post AMI patients compared to controls. 2. There is significant correlation between lower βAR and deterioration in ESV at 6 months post AMI. 3. There is a

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Saeki H, Sassetti C, Rosen SD, Schall TJ, Hwang STet al., 1998, Fractalkine. A novel CX3C chemokine, is expressed by epidermal melanocytes and Langerhans cells., Publisher: BLACKWELL SCIENCE INC, Pages: 652-652, ISSN: 0022-202X

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Baliga RR, Rosen SD, Camici PG, Kooner JSet al., 1998, Regional myocardial blood flow redistribution as a cause of postprandial angina pectoris, CIRCULATION, Vol: 97, Pages: 1144-1149, ISSN: 0009-7322

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• Citations: 24