Publications
229 results found
Burns SM, Schofield PM, Rosen SD, et al., 1998, Measurement of myocardial blood flow using positron emission tomography before and after transmyocardial revascularization, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 31, Pages: 226A-226A, ISSN: 0735-1097
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- Citations: 4
Spyrou N, Rosen SD, Foale R, et al., 1998, Left ventricular remodelling 6 months after infarction is predicted by myocardial β-adrenoceptor density at 1 month, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 31, Pages: 83A-83A, ISSN: 0735-1097
Mulnier HE, Adams L, Murphy K, et al., 1998, Areas of human cerebral cortex activated by dyspnoea, NeuroImage, Vol: 7, ISSN: 1053-8119
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- Citations: 1
Rosen SD, 1998, Functional neuroimaging of angina pectoris, 2nd European Conference on Cardiac PET Research, Publisher: SPRINGER, Pages: 137-+
Gunn MD, Tangemann K, Cyster JG, et al., 1997, A lymphoid homing chemokine that stimulates the adhesion of naive T lymphocytes to ICAM-1, Publisher: AMER SOC CELL BIOLOGY, Pages: 1377-1377, ISSN: 1059-1524
Fogle RA, Rosen SD, Boyd H, et al., 1997, Effect of alpha(1) blockade on myocardial blood flow in patients with cardiac syndrome X, CIRCULATION, Vol: 96, Pages: 3494-3494, ISSN: 0009-7322
Foale RA, Rosen SD, Paulesu E, et al., 1997, Role of the thalamus and cerebral cortex in the perception of cardiac symptoms, CIRCULATION, Vol: 96, Pages: 4272-4272, ISSN: 0009-7322
Camici PG, Rosen SD, 1997, Endothelial function in patients with chest pain and normal coronary arteries, CIRCULATION, Vol: 96, Pages: 1047-1047, ISSN: 0009-7322
Rosen SD, King JC, Nixon PGF, 1997, Hyperventilation in patients who have sustained myocardial infarction after a work injury (vol 87, pg 268, 1994), JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 90, Pages: 416-416, ISSN: 0141-0768
Rosen SD, Paulesu E, Frackowiak RSJ, et al., 1997, Is altered central processing of afferent signals the cause of chest pain in syndromex?, Heart, Vol: 77, ISSN: 1355-6037
The aetiology of syndrome X (SX, anginal pain and ischaemic-like changes in the stress ECG despite a normal coronary arteriogram) remains to be elucidated. There is increasing doubt over the myocardial ischemia hypothesis of chest pain in SX, whereas abnormalities of pain perception have been shown. To investigate the latter further, we have used positron emission tomography with H215O to measure regional cerebral blood flow (rCBF) changes as an index of neuronal activation: a) during chest pain in SX patients and b) during angina pectoris in coronary artery disease (CAD) patients. Nine SX patients [7 female, age 56 (11) mean (SD)] and 9 CAD patients [7 male, age 61(7) years] were studied. No patient had diabetes or other systemic disease. With stress, normal ventricular function was demonstrated in the SX patients despite an ischaemic-like ECG, but there were reversible wall motion abnormalities in the CAD patients. Intravenous dobutamine (D) was used to induce the chest pain. rCBF was measured during the following scan sequence: 1) rest; 2) placebo; 3) rest; 4) low dose D; 5) high dose D (provoking chest pain); and 6) rest. PET images were transformed into a standard stereotactic space and comparisons made across conditions by Statistical Parametric Mapping. Chest pain ocurred in response to low dose D in 4/9 SX but in no CAD patients (p=NS). During scan 5 (high dose D) chest pain was reported in all cases, being scored comparably by both groups (6.3 in CAD vs 7.6 in SX; p=NS). During scan 5, ischaemic-like ECG changes were noted in 9/9 CAD and 8/9 SX. The maximal D dose was equivalent for both groups. During chest pain, SX patients showed significantly greater increases in rCBF in the midbrain, right thalamus and right insular cortex and bilaterally in the frontal and prefrontal cortices. The central neural areas activated are similar in both SX and CAD, suggesting that in SX the afferent pain signals do originate from the heart. However the degree and extent of
Lorenzoni R, Gistri R, Rosen SD, et al., 1997, The measurement of myocardial blood flow with positron emission tomography is highly reproducible, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 29, Pages: 47144-47144, ISSN: 0735-1097
Spyrou N, Rosen S, Foale R, et al., 1997, Evidence of diffuse myocardial beta-adrenoceptor downregulation after myocardial infarction in the absence of cardiac failure, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 29, Pages: 7915-7915, ISSN: 0735-1097
Choudhury L, Rosen SD, Patel D, et al., 1997, Coronary vasodilator reserve in primary and secondary left ventricular hypertrophy - A study with positron emission tomography, EUROPEAN HEART JOURNAL, Vol: 18, Pages: 108-116, ISSN: 0195-668X
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- Citations: 78
Giblin PA, Hwang ST, Tangemann K, et al., 1997, Characterization of stimulated beta 1 integrin adhesion following L-selectin triggering: Comparison of the binding of soluble and immobilized fibronectin ligand., Publisher: MOSBY-YEAR BOOK INC, Pages: 1921-1921, ISSN: 0091-6749
Giblin PA, Hwang ST, Katsumoto TR, et al., 1996, L-selectin mediated signal transduction in lymphocytes: Dissection of the events leading to upregulated adhesion through the beta-1 integrins following L-selectin engagement., Publisher: AMER SOC CELL BIOLOGY, Pages: 1446-1446, ISSN: 1059-1524
Hwang ST, Giblin PA, Singer MS, et al., 1996, Ligation of L-selecting activates beta 1 integrins on peripheral blood lymphocytes and T cell lines, Publisher: AMER SOC CELL BIOLOGY, Pages: 1448-1448, ISSN: 1059-1524
Choudhury L, Rosen SD, Lefroy DC, et al., 1996, Myocardial beta adrenoceptor density in primary and secondary left ventricular hypertrophy, EUROPEAN HEART JOURNAL, Vol: 17, Pages: 1703-1709, ISSN: 0195-668X
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- Citations: 32
Lorenzoni R, Rosen SD, Camici PG, 1996, Effect of alpha(1)-adrenoceptor blockade on resting and hyperemic myocardial blood flow in normal humans, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 271, Pages: H1302-H1306, ISSN: 0363-6135
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- Citations: 36
Rosen SD, Boyd H, Rhodes CG, et al., 1996, Myocardial beta-adrenoceptor density and plasma catecholamines in syndrome X, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 78, Pages: 37-42, ISSN: 0002-9149
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- Citations: 13
Rosen SD, Paulesu E, Nihoyannopoulos P, et al., 1996, Silent ischemia as a central problem: Regional brain activation compared in silent and painful myocardial ischemia, ANNALS OF INTERNAL MEDICINE, Vol: 124, Pages: 939-+, ISSN: 0003-4819
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- Citations: 146
Rosen SD, Paulesu E, Nihoyannopoulos P, et al., 1996, Silent ischemia as a central problem: regional brain activation compared in silent and painful myocardial ischemia., Ann Intern Med, Vol: 124, Pages: 939-949, ISSN: 0003-4819
OBJECTIVE: To test whether the silence of painless myocardial ischemia is caused by abnormal handling by the central nervous system of afferent messages from the heart. DESIGN: Nonrandomized study. SETTING: A tertiary referral center (postgraduate medical school). PATIENTS: 2 matched groups of nondiabetic patients with coronary artery disease. Group A consisted of nine patients with reproducible stress-induced angina; group B consisted of nine patients with reproducible stress-induced myocardial ischemia but no angina. INTERVENTIONS: Intravenous placebo infusion and low-dose (5 and 10 micrograms/ kg per minute) and high-dose (20 to 35 micrograms/kg per minute) dobutamine infusions. MEASUREMENTS: Positron emission tomography was used to measure regional cerebral blood flow changes as an index of neuronal activation during painful and silent myocardial ischemia induced by intravenous dobutamine. RESULTS: Regional cerebral blood flow changes during myocardial ischemia were compared with those during baseline conditions and during placebo infusion. During myocardial ischemia, regional cerebral blood flow increased bilaterally in the thalami and prefrontal, basal frontal, and ventral cingulate corticles in patients in group A. Both thalami were activated in group B, but cortical activation was limited to the right frontal region. A formal comparison of groups A and B showed significant differences (P < 0.01) in activation of the basal frontal cortex, ventral cingulate cortex, and left temporal pole. In both groups, thalamic regional cerebral blood flow remained increased after the symptoms and signs of ischemia had ceased. CONCLUSIONS: Bilateral activation of the thalamus can be shown in both angina and silent ischemia; thus, peripheral nerve dysfunction cannot completely explain silent ischemia. Frontal cortical activation appears to be necessary for the sensation of pain. Abnormal central processing of afferent pain messages from the heart may play a determining rol
Tousoulis D, Davies G, Lefroy DC, et al., 1996, Localised endothelial dysfunction in patients with chest pain and normal coronary arteriograms, Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: 253-253, ISSN: 1355-6037
Hwang ST, Singer M, Giblin PA, et al., 1996, L-selectin ligands in skin: Expression in lesional skin of patients with cutaneous T-cell lymphoma and in vitro mechanism of stimulation of adhesion to ICAM-1 and fibronectin., Publisher: BLACKWELL SCIENCE INC, Pages: 777-777, ISSN: 0022-202X
Camici PG, Rosen SD, 1996, Does positron emission tomography contribute to the management of clinical cardiac problems?, EUROPEAN HEART JOURNAL, Vol: 17, Pages: 174-181, ISSN: 0195-668X
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- Citations: 9
Cunningham VJ, Rosen SD, Boyd H, et al., 1996, Uptake of [N-methyl-11C]propionyl-L-carnitine (PLC) in human myocardium, J Pharmacol Exp Ther, Vol: 277, Pages: 511-517, ISSN: 0022-3565
We studied the uptake of propionyl-L-carnitine from plasma by the myocardium in 10 human subjects using positron emission tomography. Propionyl-L-carnitine was labeled in the N-methyl position with carbon-11 (T1/2 = 20.4 min) and administered i.v. in trace amounts. The uptake of the radiolabel by the myocardium was then scanned over a period of 1 1/2 h. The activity-time course of the tracer in blood and plasma and the exchange of the label in plasma between propionyl carnitine, acetyl carnitine and free carnitine was followed during the scans. Myocardial blood flow was also measured in the same subjects. The results show an exchange of the tracer between the myocardium and plasma, and they show an apparently irreversible component of uptake, a result consistent with the incorporation of the label into relatively large intracellular carnitine pools.
UREN NG, CAMICI PG, MELIN JA, et al., 1995, EFFECT OF AGING ON MYOCARDIAL PERFUSION RESERVE, JOURNAL OF NUCLEAR MEDICINE, Vol: 36, Pages: 2032-2036, ISSN: 0161-5505
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- Citations: 143
ROSEN SD, BOYD H, RHODES CG, et al., 1995, IS OVERACTIVITY OF THE SYMPATHETIC NERVOUS-SYSTEM DEMONSTRABLE IN PATIENTS WITH SYNDROME-X, CIRCULATION, Vol: 92, Pages: 3130-3130, ISSN: 0009-7322
ROSEN SD, PAULESU E, FRACKOWIAK RSJ, et al., 1995, CENTRAL NEURAL CORRELATES OF CHEST PAIN IN SYNDROME-X, CIRCULATION, Vol: 92, Pages: 3126-3126, ISSN: 0009-7322
NIHOYANNOPOULOS P, ROSEN S, KRZYZOWSKADICKINSON K, et al., 1995, LEFT-VENTRICULAR FUNCTION AND REGIONAL MYOCARDIAL PERFUSION DURING DIPYRIDAMOLE STRESS IN PATIENTS WITH SYNDROME-X, CIRCULATION, Vol: 92, Pages: 1959-1959, ISSN: 0009-7322
MANNING DD, BERTOZZI CR, ROSEN SD, et al., 1995, SELECTIVE PHOSPHORYLATION OF LEWIS A ANALOGS AND SELECTIN BINDING, Publisher: AMER CHEMICAL SOC, Pages: 366-ORGN, ISSN: 0065-7727
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