Publications
229 results found
Wage R, Patel H, Smith GC, et al., 2015, The utility of magnetic resonance imaging in a trial to assess the effect of renal denervation in heart failure with preserved ejection fraction, Journal of Cardiovascular Magnetic Resonance, Pages: 1-2, ISSN: 1097-6647
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- Citations: 1
Knott K, Starling N, Rasheed S, et al., 2014, A case of Takotsubo syndrome following 5-fluorouracil chemotherapy, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 177, Pages: E65-E67, ISSN: 0167-5273
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- Citations: 15
Rimoldi O, Rosen SD, Camici PG, 2014, The blunting of coronary flow reserve in hypertension with left ventricular hypertrophy is transmural and correlates with systolic blood pressure, JOURNAL OF HYPERTENSION, Vol: 32, Pages: 2465-2471, ISSN: 0263-6352
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- Citations: 30
Patel HC, Hayward C, Ozdemir BA, et al., 2014, Magnitude of Blood Pressure Reduction in the Placebo Arms of Modern Hypertension Trials Implications for Trials of Renal Denervation, Hypertension, Vol: 65, Pages: 401-406, ISSN: 1524-4563
Patel HC, Hayward C, di Mario C, et al., 2014, Heart failure with preserved ejection fraction: the impact of stricter definitions, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 16, Pages: 767-771, ISSN: 1388-9842
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- Citations: 18
Patel H, Middleton L, Hayward C, et al., 2014, AUTONOMIC RESPONSES TO HEAD UP TILT IN PATIENTS WITH SYNCOPE: THE INFLUENCE OF AGEING, HEART, Vol: 100, Pages: A5-A5, ISSN: 1355-6037
Patel H, Hayward C, di Mario C, et al., 2014, HEART FAILURE WITH PRESERVED EJECTION FRACTION: ARE THE CURRENT DEFINITIONS TOO STRICT?, HEART, Vol: 100, Pages: A36-A36, ISSN: 1355-6037
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- Citations: 1
Langley RE, Truinh D, Jovic G, et al., 2014, Prostate Adenocarcinoma: TransCutaneons Hormones, PR09 (PATCH): A randomized controlled trial of transdemal estrogen patches versus luteinising hormone releasing hormone agonists in locally advanced and metastatic prostate cancer., 50th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0732-183X
Patel HC, Dhillon PS, Mahfoud F, et al., 2014, The biophysics of renal sympathetic denervation using radiofrequency energy, CLINICAL RESEARCH IN CARDIOLOGY, Vol: 103, Pages: 337-344, ISSN: 1861-0684
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- Citations: 26
Patel HC, Rosen SD, Lindsay A, et al., 2013, Targeting the autonomic nervous system: Measuring autonomic function and novel devices for heart failure management, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 170, Pages: 107-117, ISSN: 0167-5273
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- Citations: 28
Ward NR, Roldao V, Cowie MR, et al., 2013, The Effect of Respiratory Scoring on the Diagnosis and Classification of Sleep Disordered Breathing in Chronic Heart Failure, SLEEP, Vol: 36, Pages: 1341-1348, ISSN: 0161-8105
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- Citations: 21
Rosen SD, 2013, Trastuzumab induced cardiomyopathy: wider implications for cardio-oncology, HEART, Vol: 99, Pages: 599-600, ISSN: 1355-6037
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- Citations: 5
Langley RE, Cafferty FH, Alhasso AA, et al., 2013, Cardiovascular outcomes in patients with locally advanced and metastatic prostate cancer treated with luteinising-hormone-releasing-hormone agonists or transdermal oestrogen: the randomised, phase 2 MRC PATCH trial (PR09), LANCET ONCOLOGY, Vol: 14, Pages: 306-316, ISSN: 1470-2045
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- Citations: 69
Ward NR, Cowie MR, Rosen SD, et al., 2012, Utility of overnight pulse oximetry and heart rate variability analysis to screen for sleep-disordered breathing in chronic heart failure, THORAX, Vol: 67, Pages: 1000-1005, ISSN: 0040-6376
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- Citations: 27
Rosen S, 2012, Calmen Rosen OBITUARY, BRITISH MEDICAL JOURNAL, Vol: 345, ISSN: 1756-1833
Rosen SD, 2011, From Heart to Brain: The Genesis and Processing of Cardiac Pain, CANADIAN JOURNAL OF CARDIOLOGY, Vol: 28, Pages: S7-S19, ISSN: 0828-282X
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- Citations: 41
Patel H, Ozdemir BA, Patel M, et al., 2011, Impairment of autonomic reactivity is a feature of heart failure whether or not the left ventricular ejection fraction is normal, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 151, Pages: 34-39, ISSN: 0167-5273
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- Citations: 17
Michie CA, Rosen SD, Guirguis R, 2011, Venous thromboembolism, statins and the protein unfolding response, INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Vol: 65, Pages: 376-377, ISSN: 1368-5031
Abel PD, Sundaram SK, Kynaston HG, et al., 2011, Cardiovascular events and clinical responses in prostate cancer patients treated with transcutaneous estrogen patches compared with LHRH analogues: Results from a randomized phase II trial (MRC PR09 PATCH), JOURNAL OF CLINICAL ONCOLOGY, Vol: 29, ISSN: 0732-183X
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- Citations: 6
Abel PD, Sundaram SK, Kynaston HG, et al., 2011, Cardiovascular events and clinical responses in prostate cancer patients treated with transcutaneous estrogen patches compared with LHRH analogues: Results from a randomized phase II trial (MRC PR09 PATCH)., J Clin Oncol, Vol: 29
201 Background: Androgen-deprivation therapy (ADT) with a luteinising hormone-releasing hormone analogue (LHRHa) is widely used in the management of prostate cancer. LHRHa suppresses testosterone to castrate levels but can lead to long term toxicities including osteoporosis, adverse metabolic effects and cardiovascular (CV) complications. Transcutaneous oestrogen is an attractive potential alternative to ADT. This approach circumvents first-pass hepatic metabolism and so should avoid the CV effects previously reported with oral oestrogen in men with prostate cancer. Castrate levels of testosterone, and hence prostate cancer outcomes, are expected to be equivalent but the side-effects associated with ADT will potentially be avoided. METHODS: PATCH is a multi-centre phase II randomized study of 254 men with locally advanced or metastatic prostate cancer assigned (2:1) to either oestrogen patches (Merck FemSeven 100mcg/24hr; 4 patches changed twice-weekly, reducing to 3 after 4 weeks) or LHRHa. The primary outcome is CV morbidity and mortality, including arterial and venous thromboembolic events, acute coronary syndrome and heart failure. These have been assessed by an independent committee, blind to the treatment arm. Secondary outcome measures include PSA response, serum testosterone and also toxicities. RESULTS: Baseline data on the 254 men will be presented including age, cardiovascular risk factors (smoking history, lipid levels and family history), and stage/grade of tumour at presentation and randomisation. CV events will be presented by randomisation arm and by treatment at the time of the event. Data relating to rates of castrate levels of hormones, PSA responses, sexual dysfunction, other toxicities (including gynaecomastia, hot flushes, anaemia and bone fractures) and compliance will also be available. CONCLUSIONS: Providing the data demonstrate that the patches are a safe and potentially efficacious therapy we propose to recruit a further 410 patients with
Ward NR, Roldao V, Cowie MR, et al., 2011, Utility Of Pulse Oximetry Versus Heart Rate Variability To Screen For Sleep-Disordered Breathing In Chronic Heart Failure, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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- Citations: 1
Ward NR, Cowie MR, Rosen SD, et al., 2010, DETECTION OF SLEEP-DISORDERED BREATHING IN CHRONIC HEART FAILURE PATIENTS: UTILITY OF HEART RATE VARIABILITY VERSUS PULSE OXIMETRY?, British-Thoracic-Society-Winter-Meeting 2010, Publisher: B M J PUBLISHING GROUP, Pages: A10-A11, ISSN: 0040-6376
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- Citations: 1
Gaemperli O, Liga R, Spyrou N, et al., 2010, Myocardial beta-adrenoceptor density early after infarction correlates with long term incidence of congestive heart failure, ESC Congress, Publisher: OXFORD UNIV PRESS, Pages: 610-611, ISSN: 0195-668X
Gaemperli O, Liga R, Spyrou N, et al., 2010, Myocardial β-adrenoceptor down-regulation early after infarction is associated with long-term incidence of congestive heart failure, EUROPEAN HEART JOURNAL, Vol: 31, Pages: 1722-1729, ISSN: 0195-668X
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- Citations: 22
Ward NR, Roldao V, Rosen SD, et al., 2010, How Often Do Mixed Apneas Occur In Chronic Heart Failure Patients and What Is Their Impact On Diagnosis Of Sleep-Disordered Breathing?, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Gaemperli O, Liga R, Spyrou N, et al., 2009, Measurement of Myocardial β-Adrenoceptor Density Early After Myocardial Infarction Predicts Incidence of Congestive Heart Failure at Follow Up, Basic Cardiovascular Sciences Conference 2009, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: E60-E60, ISSN: 0009-7330
Riley J, Dar O, Chapman C, et al., 2009, Telemonitoring in heart failure increases patients' confidence in self care but identifies additional healthcare needs: the Home-HF study, EUROPEAN HEART JOURNAL, Vol: 30, Pages: 863-863, ISSN: 0195-668X
ROSEN SD, 2009, PACEMAKER IMPLANTATION CEREBRAL FUNCTION, GERONTOLOGY, Vol: 40, Pages: 286-288, ISSN: 0304-324X
Dar O, Riley J, Chapman C, et al., 2009, A randomized trial of home telemonitoring in a typical elderly heart failure population in North West London: results of the Home-HF study, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 11, Pages: 319-325, ISSN: 1388-9842
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- Citations: 108
Rosen SD, Camici PG, 2009, The Sensitive Heart: some thoughts on the nature of a chronic cardiac pain syndrome., Functional Pain Syndromes: Presentation and Pathophysiology, Seattle, Publisher: IASP Press, Pages: 121-149
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