Publications
287 results found
Sun M, Moquet J, Ellender M, et al., 2023, Potential risks associated with the use of ionizing radiation for imaging and treatment of colorectal cancer in Lynch syndrome patients, Familial Cancer, Vol: 22, Pages: 61-70, ISSN: 1389-9600
The aim of this review is to investigate the literature pertaining to the potential risks of low-dose ionizing radiation to Lynch syndrome patients by use of computed tomography (CT), either diagnostic CT colonography (CTC), standard staging CT or CT surveillance. Furthermore, this review explores the potential risks of using radiotherapy for treatment of rectal cancer in these patients. No data or longitudinal observational studies of the impact of radiation exposure on humans with Lynch syndrome were identified. Limited experimental studies utilizing cell lines and primary cells exposed to both low and high radiation doses have been carried out to help determine radio-sensitivity associated with DNA mismatch repair gene deficiency, the defining feature of Lynch syndrome. On balance, these studies suggest that mismatch repair deficient cells may be relatively radio-resistant (particularly for low dose rate exposures) with higher mutation rates, albeit no firm conclusions can be drawn. Mouse model studies, though, showed an increased risk of developing colorectal tumors in mismatch repair deficient mice exposed to radiation doses around 2 Gy. With appropriate ethical approval, further studies investigating radiation risks associated with CT imaging and radiotherapy relevant doses using cells/tissues derived from confirmed Lynch patients or genetically modified animal models are urgently required for future clinical guidance.
Noble A, Durant L, Dilke SM, et al., 2022, Altered Mucosal Immune-Microbiota Interactions in Familial Adenomatous Polyposis, CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, Vol: 13
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- Citations: 2
Clark SK, 2022, Genetic Testing in Colorectal Surgery: Routine Profiling of Tumor Genomes is Not Far Off, DISEASES OF THE COLON & RECTUM, Vol: 65, Pages: 783-784, ISSN: 0012-3706
Anele CC, Martin I, Duggan PMM, et al., 2022, Attenuated Familial Adenomatous Polyposis: A Phenotypic Diagnosis but Obsolete Term?, DISEASES OF THE COLON & RECTUM, Vol: 65, Pages: 529-535, ISSN: 0012-3706
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- Citations: 1
Latchford AR, Clark SK, 2022, Gastrointestinal aspects of Peutz-Jeghers syndrome., Best Pract Res Clin Gastroenterol, Vol: 58-59
There are two main problems in the clinical management of the gastrointestinal (GI) tract in patients with Peutz-Jeghers syndrome (PJS), namely long-term cancer risk and managing polyp related complications (of which the most important clinically is intussusception). Given the rarity of this condition, the evidence base upon which to make recommendations is small. Furthermore, controversies persist regarding the relationship between PJ polyps, cancer development and cancer risk. In this article we will explore some of these controversies, to put into context the recommendations for clinical management of these patients. We will provide an overview, particularly focusing on clinical data, and on the recommendations for clinical management and surveillance of the GI tract in PJS. We highlight knowledge gaps which need to be addressed by further research.
Anele CC, Xiang J, Martin I, et al., 2021, Regular endoscopic surveillance and polypectomy is effective in managing rectal adenoma progression following colectomy and ileorectal anastomosis in patients with familial adenomatous polyposis, COLORECTAL DISEASE, Vol: 24, Pages: 277-283, ISSN: 1462-8910
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- Citations: 2
Mak S, Latchford A, Hawkins M, et al., 2021, DIAGNOSTIC YIELD OF CONSTITUTIONAL GENETIC TESTING IN PATIENTS WITH MULTIPLE COLORECTAL ADENOMAS (MCRA), Publisher: BMJ PUBLISHING GROUP, Pages: A16-A17, ISSN: 0017-5749
Patel R, McGinty P, Cuthill V, et al., 2021, Risk of colorectal adenomas and cancer in monoallelic carriers of MUTYH pathogenic variants: a single-centre experience, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, Vol: 36, Pages: 2199-2204, ISSN: 0179-1958
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- Citations: 3
Patel R, Reza L, Worley GHT, et al., 2021, Presentation, management and outcomes of ileoanal pouch cancer: a single-centre experience, COLORECTAL DISEASE, Vol: 23, Pages: 2041-2051, ISSN: 1462-8910
Worley G, Burling D, Corr A, et al., 2021, MRI-enema for the assessment of pelvic intestinal anastomotic integrity, COLORECTAL DISEASE, Vol: 23, Pages: 1890-1899, ISSN: 1462-8910
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- Citations: 1
Palles C, Martin L, Domingo E, et al., 2021, The clinical features of polymerase proof-reading associated polyposis (PPAP) and recommendations for patient management, FAMILIAL CANCER, Vol: 21, Pages: 197-209, ISSN: 1389-9600
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- Citations: 9
Martin I, Wu Y, Patel R, et al., 2021, A NOVEL BOWEL DISEASE MODEL: PHENOTYPIC DIVERSITY OF CONTROL VS FAP ORGANOIDS, Publisher: OXFORD UNIV PRESS, Pages: 8-8, ISSN: 0007-1323
Deputy M, Segal J, Reza L, et al., 2021, The pouch behaving badly: management of morbidity after ileal pouch-anal anastomosis, COLORECTAL DISEASE, Vol: 23, Pages: 1193-1204, ISSN: 1462-8910
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- Citations: 4
McDermott FD, Newton K, Beggs AD, et al., 2021, Implications for the colorectal surgeon following the 100 000 Genomes Project, COLORECTAL DISEASE, Vol: 23, Pages: 1049-1058, ISSN: 1462-8910
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- Citations: 4
Thomas LE, Hurley JJ, Sanchez AA, et al., 2021, Duodenal Adenomas and Cancer in MUTYH-associated Polyposis: An International Cohort Study, GASTROENTEROLOGY, Vol: 160, Pages: 952-+, ISSN: 0016-5085
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- Citations: 7
Segal JP, Askari A, Clark SK, et al., 2021, The Incidence and Prevalence of Human Papilloma Virus-associated Cancers in IBD, INFLAMMATORY BOWEL DISEASES, Vol: 27, Pages: 34-39, ISSN: 1078-0998
Anele CC, Xiang J, Martin I, et al., 2020, Polyp Progression in Paediatric Patients With Familial Adenomatous Polyposis: A Single-centre Experience., J Pediatr Gastroenterol Nutr, Vol: 71, Pages: 612-616
OBJECTIVES: Prophylactic colectomy at a premalignant stage is the cornerstone of management of familial adenomatous polyposis (FAP). Before surgery, colonoscopy surveillance is recommended in children with FAP. This study aimed to examine the natural history of FAP in children by evaluating adenoma progression and factors influencing timing of colectomy. METHOD: Patients with FAP younger than 18 years at first surveillance colonoscopy and who had undergone more than 1 colonoscopy were identified. Demographic, endoscopic, genetic, and surgical data were retrieved. Cumulative adenoma (polyp) counts were obtained while accounting for any polypectomies during the study period. The rate of polyp progression and factors influencing the timing of colectomy were evaluated. RESULTS: Eighty-four patients (50% boys; mean age at first colonoscopy 13 years [standard deviation 1.97]) were identified, of which 83 had a family history of FAP. At first colonoscopy, 67 (79%) had <100 adenomas and 29 (35%) had colonic polyps identified despite rectal sparing. The median rate of polyp progression per patient was 12.5 polyps/year (range 0-145). Of the 45 (54%) patients who had undergone surgery, 41 (91%) underwent colectomy with ileorectal or ileodistal sigmoid anastomosis. Polyp progression did not alter the choice of surgical intervention in any patient. CONCLUSION: Our results suggest that adenoma number remains relatively stable in the majority of children under surveillance. Tailored surveillance intervals according to phenotype are a more appropriate strategy as recommended by recently published guidelines.
Sehmbhi M, Sellers P, Segal J, et al., 2020, Interesting case of dual pathology: Crohn's disease and Peutz-Jeghers syndrome, BMJ CASE REPORTS, Vol: 13
ACPGBI Legacy Working Group, 2020, Legacy of COVID-19 - the opportunity to enhance surgical services for patients with colorectal disease., Colorectal Dis, Vol: 22, Pages: 1219-1228
Martin I, Roos VH, Anele C, et al., 2020, Gastric adenomas and their management in familial adenomatous polyposis, ENDOSCOPY, Vol: 53, Pages: 795-801, ISSN: 0013-726X
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- Citations: 5
Segal JP, Askari A, Clark SK, et al., 2020, HPV-related Cancers in Inflammatory Bowel Disease: Association Not Yet Causation, INFLAMMATORY BOWEL DISEASES, Vol: 26, Pages: E102-E102, ISSN: 1078-0998
Anele CC, Xiang J, Martin I, et al., 2020, Polyp Progression in Paediatric Patients with Familial Adenomatous Polyposis - A Single Centre Experience., Journal of Pediatric Gastroenterology and Nutrition, ISSN: 0277-2116
OBJECTIVES: Prophylactic colectomy at a premalignant stage is the cornerstone of management of familial adenomatous polyposis (FAP). Prior to surgery, colonoscopy surveillance is recommended in children with FAP. This study aimed to examine the natural history of FAP in children by evaluating adenoma progression and factors influencing timing of colectomy. METHOD: Patients with FAP under the age of 18 years at first surveillance colonoscopy and who had undergone more than one colonoscopy were identified. Demographic, endoscopic, genetic and surgical data were retrieved. Cumulative adenoma (polyp) counts were obtained whilst accounting for any polypectomies during the study period. The rate of polyp progression and factors influencing the timing of colectomy.were evaluated. RESULTS: Eighty-four patients (50% male; mean age at first colonoscopy 13 years [SD 1.97]) were identified, of which 83 had a family history of FAP. At first colonoscopy, 67 (79%) had <100 adenomas and 29 (35%) had colonic polyps identified despite rectal sparing. The median rate of polyp progression per patient was 12.5 polyps/year (range 0-145). Of the 45 (54%) patients who had undergone surgery, 41 (91%) underwent colectomy with ileorectal or ileodistal sigmoid anastomosis. Polyp progression did not alter the choice of surgical intervention in any patient. CONCLUSION: Our results suggest that adenoma number remains relatively stable in the majority of children under surveillance. Tailored surveillance intervals according to phenotype are a more appropriate strategy as recommended by recently published guidelines.
Patel R, McGinty P, Cuthill V, et al., 2020, MUTYH-associated polyposis - colorectal phenotype and management, COLORECTAL DISEASE, Vol: 22, Pages: 1271-1278, ISSN: 1462-8910
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- Citations: 1
Reza LM, Lung PFC, Lightner AL, et al., 2020, Perianal fistula and the ileoanal pouch - different aetiologies require distinct evaluation, COLORECTAL DISEASE, Vol: 22, Pages: 1436-1439, ISSN: 1462-8910
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- Citations: 7
Latchford AR, Maeda Y, Clark SK, 2020, Nonsteroidal anti-inflammatory drugs (NSAID) and aspirin for preventing colorectal adenomas and carcinomas in patients with previous adenomas and/or genetic disposition, Cochrane Database of Systematic Reviews, Vol: 2020
This protocol for a Cochrane Review has been withdrawn. Reason for withdrawal: Authors have made no progress with this protocol in 3 years. New authors are being sought to take over this protocol. The protocol is being withdrawn by Kristoffer Andresen, Managing Editor - Cochrane Colorectal Group. The authors have agreed to the withdrawal.
Latchford AR, Maeda Y, Clark SK, 2020, Nonsteroidal anti-inflammatory drugs (NSAID) and aspirin for preventing colorectal adenomas and carcinomas in general population, Cochrane Database of Systematic Reviews, Vol: 2020
This protocol for a Cochrane Review has been withdrawn. Reason for withdrawal: Authors have made no progress with this protocol in 3 years. New authors are being sought to take over this protocol. The protocol is being withdrawn by Kristoffer Andresen, Managing Editor - Cochrane Colorectal Group. The authors have agreed to the withdrawal.
Latchford AR, Maeda Y, Clark SK, 2020, Nonsteroidal anti-inflammatory drugs (NSAID) and aspirin for preventing recurrence and metachronous colorectal carcinomas in patients previously treated for colorectal cancer, Cochrane Database of Systematic Reviews, Vol: 2020
This protocol for a Cochrane Review has been withdrawn. Reason for withdrawal: Authors have made no progress with this protocol in 3 years. New authors are being sought to take over this protocol. The protocol is being withdrawn by Kristoffer Andresen, Managing Editor - Cochrane Colorectal Group. The authors have agreed to the withdrawal.
Anele CC, Nachiappan S, Sinha A, et al., 2020, Safety and efficacy of laparoscopic near-total colectomy and ileo-distal sigmoid anastomosis as a modification of total colectomy and ileorectal anastomosis for prophylactic surgery in patients with adenomatous polyposis syndromes: a comparative study, COLORECTAL DISEASE, Vol: 22, Pages: 799-805, ISSN: 1462-8910
Segal J, Mullish B, Clark S, et al., 2020, P844 Higher proportions of genera and species in the Firmicutes phylum are associated with a healthy pouch compared with patients with chronic pouchitis, Journal of Crohn's and Colitis, Vol: 14, Pages: S652-S652, ISSN: 1873-9946
BackgroundStudies highlighting changes in bacterial composition in the ileoanal pouch are limited by heterogeneity in analysis techniques and sampling strategies Therefore, caution must be used when interpreting microbiota data. Similar to findings in IBD, a decrease in bacterial diversity and ‘dysbiosis’ are associated with acute and chronic inflammation in the pouch. Changes in Clostridium spp. and E. coli are associated with inflamed pouches and treatment response. This study aimed to compare the bacterial microbiota composition in patients with chronic pouchitis who responded to antibiotics vs. those who did not.MethodsPatients with confirmed chronic pouchitis defined by a pouch disease activity score ≥ 7 were treated with antibiotics. If patients were already on antibiotics, they were offered the opportunity to stop. Follow up was at 4 weeks to check clinical status. Patients who came off antibiotics who flared were given the opportunity to restart the antibiotics to prevent deterioration. Patients were analysed as either on antibiotics if they received antibiotics 2 weeks prior to the clinic or off antibiotics if they had stopped all antibiotics 2 weeks prior to follow-up. Stool was collected from patients on follow-up and DNA was extracted from this stool. Sequencing was performed on an Illumina platform. Statistical analysis was performed using STAMP 2.1.3 software with Welch’s two-sided t-test for comparing two groups with false discovery rate correction.ResultsThere were 28 patients in the cohort; 23 patients with chronic pouchitis and 5 healthy controls who had never had pouchitis. Ten patients were female. The median age of the cohort was 47 years (range 26–74 years). A total of 12 samples on antibiotics and 11 off antibiotics. There were 10 responders and 13 non-responders. There were no differences between responders and non-responders and no differences in those taking antibiotics vs. those not taking antibiotics with chroni
Martin I, Hawkins J, Hyer W, et al., 2020, Upper GI in patients with FAP-the need for formal research, GASTROINTESTINAL ENDOSCOPY, Vol: 91, Pages: 206-207, ISSN: 0016-5107
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- Citations: 1
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