Publications
289 results found
Ignjatovic A, Saunders BP, Harbin L, et al., 2010, Solitary 'rectal' ulcer syndrome in the sigmoid colon, COLORECTAL DISEASE, Vol: 12, Pages: 1163-1164, ISSN: 1462-8910
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- Citations: 8
Sinha A, Gibbons DC, Phillips RKS, et al., 2010, Surgical prophylaxis in familial adenomatous polyposis - do pre existing desmoids outside the abdominal cavity matter?, Annual Meeting of the Society-of-Academic-and-Research-Surgeons, Publisher: JOHN WILEY & SONS LTD, Pages: 21-21, ISSN: 0007-1323
Sinha A, Neale KF, Phillips RK, et al., 2010, Jejunal Cancer in Patients With Familial Adenomatous Polyposis, CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, Vol: 8, Pages: 904-904, ISSN: 1542-3565
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- Citations: 2
Smith JJ, Nicholls RJ, 2010, The Development of a Social Morbidity Score in Patients with Chronic Ulcerative Colitis as a Guide to Treatment, QUALITY OF LIFE RESEARCH, Vol: 19, Pages: 116-116, ISSN: 0962-9343
McLaughlin SD, Clark SK, Roberts CH, et al., 2010, Extended spectrum beta-lactamase-producing bacteria and <i>Clostridium difficile</i> in patients with pouchitis, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 32, Pages: 664-669, ISSN: 0269-2813
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- Citations: 12
Sinha A, Gibbons DC, Phillips RK, et al., 2010, Surgical prophylaxis in familial adenomatous polyposis: do pre-existing desmoids outside the abdominal cavity matter?, FAMILIAL CANCER, Vol: 9, Pages: 407-411, ISSN: 1389-9600
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- Citations: 2
Will OC, Leedham SJ, Elia G, et al., 2010, Location in the large bowel influences the APC mutations observed in FAP adenomas, FAMILIAL CANCER, Vol: 9, Pages: 389-393, ISSN: 1389-9600
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- Citations: 8
Farinella E, Soobrah R, Phillips RKS, et al., 2010, Familial adenomatous polyposis (FAP) and gender. Does gender influence the genetic transmission of FAP?, FAMILIAL CANCER, Vol: 9, Pages: 405-406, ISSN: 1389-9600
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- Citations: 2
McLaughlin SD, Walker AW, Churcher C, et al., 2010, The Bacteriology of Pouchitis <i>A Molecular Phylogenetic Analysis Using 16S rRNA Gene Cloning and Sequencing</i>, ANNALS OF SURGERY, Vol: 252, Pages: 90-98, ISSN: 0003-4932
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- Citations: 86
West NJ, Clark SK, Phillips RKS, et al., 2010, Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis, GUT, Vol: 59, Pages: 918-925, ISSN: 0017-5749
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- Citations: 155
Gupta A, Postgate AJ, Burling D, et al., 2010, A Prospective Study of MR Enterography Versus Capsule Endoscopy for the Surveillance of Adult Patients With Peutz-Jeghers Syndrome, AMERICAN JOURNAL OF ROENTGENOLOGY, Vol: 195, Pages: 108-116, ISSN: 0361-803X
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- Citations: 80
Beggs AD, Latchford AR, Vasen HFA, et al., 2010, Peutz-Jeghers syndrome: a systematic review and recommendations for management, GUT, Vol: 59, Pages: 975-986, ISSN: 0017-5749
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- Citations: 421
Sinha A, Tekkis PP, Neale KF, et al., 2010, Risk factors predicting intra-abdominal desmoids in familial adenomatous polyposis: a single centre experience, TECHNIQUES IN COLOPROCTOLOGY, Vol: 14, Pages: 141-146, ISSN: 1123-6337
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- Citations: 17
Beggs AD, Latchford AR, Vasen HFA, et al., 2010, Peutz-Jeghers syndrome: a systematic review and recommendations for management, Gut, Vol: 59, Pages: 975-986
Thirlwell C, Will OCC, Domingo E, et al., 2010, Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas, Gastroenterology, Vol: 138, Pages: 1441-7
Maeda Y, Molina ME, Norton C, et al., 2010, The role of pouch compliance measurement in the management of pouch dysfunction, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, Vol: 25, Pages: 499-507, ISSN: 0179-1958
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- Citations: 2
McLaughlin SD, Perry-Woodford ZL, Clark SK, et al., 2010, Osteoporosis in Patients Over 50 Years of Age Following Restorative Proctocolectomy for Ulcerative Colitis: Is DXA Screening Warranted?, INFLAMMATORY BOWEL DISEASES, Vol: 16, Pages: 250-255, ISSN: 1078-0998
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- Citations: 8
Clark SK, Neale KF, Phillips RKS, 2010, History: Familial Adenomatous Polyposis, HEREDITARY COLORECTAL CANCER, Editors: RodriguezBigas, Cutait, Lynch, Tomlinson, Vasen, Publisher: SPRINGER, Pages: 3-14, ISBN: 978-1-4419-6602-5
Faiz O, Warusavitarne J, Bottle A, et al., 2010, Nonelective excisional colorectal surgery in English National Health Service Trusts: a study of outcomes from Hospital Episode Statistics Data between 1996 and 2007, Journal of the American College of Surgeons, Vol: 210, Pages: 390-401, ISSN: 1879-1190
BACKGROUND: Nonelective colorectal surgery is associated with substantial patient morbidity and mortality. This study sought to describe the practice of emergency colorectal surgery in the United Kingdom during an 11-year period using the Hospital Episode Statistics (HES) database. STUDY DESIGN: All nonelective admissions in patients undergoing 1 of 8 colorectal resectional procedures between 1996 and 2007 were included. Time trends, univariate, and multivariate mortality and length of stay outcomes were analyzed. RESULTS: A total of 102,236 major urgent/emergency procedures were performed in English National Health Service Trusts between April 1996 and March 2007. Thirty-day in-hospital postoperative mortality rates in patients with colorectal cancer and diverticular disease were 13.3% and 15.4%, respectively. The corresponding 1-year postoperative mortality was 34.7% and 22.6%. On multivariate analysis, benign diagnosis, advanced age, high comorbidity score, social deprivation, and specific procedure types were independent predictors of early and 1-year postoperative mortality (p < 0.001). Independent risk factors for extended hospital stay were advanced age, social deprivation, distal (compared with proximal) bowel resection, and a diagnosis of ulcerative colitis (p < 0.001). CONCLUSIONS: HES data suggest that in everyday practice, postoperative mortality among patients undergoing nonelective admission followed by colorectal resection is high. Additional investigation is required to assess the reliability of HES data for monitoring institutional variation in this context.
Postgate AJ, Will OC, Fraser CH, et al., 2009, Capsule endoscopy for the small bowel in juvenile polyposis syndrome: a case series, ENDOSCOPY, Vol: 41, Pages: 1001-1004, ISSN: 0013-726X
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- Citations: 24
Will OCC, Hansmann A, Phillips RKS, et al., 2009, Adrenal Incidentaloma in Familial Adenomatous Polyposis: A Long-Term Follow-Up Study and Schema for Management, DISEASES OF THE COLON & RECTUM, Vol: 52, Pages: 1637-1644, ISSN: 0012-3706
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- Citations: 6
McLaughlin SD, Clark SK, Thomas-Gibson S, et al., 2009, Guide to Endoscopy of the Ileo-anal Pouch Following Restorative Proctocolectomy with Ileal Pouch-anal Anastomosis; Indications, Technique, and Management of Common Findings, INFLAMMATORY BOWEL DISEASES, Vol: 15, Pages: 1256-1263, ISSN: 1078-0998
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- Citations: 30
Latchford AR, Neale KF, Spigelman AD, et al., 2009, Features of duodenal cancer in patients with familial adenomatous polyposis., Clin Gastroenterol Hepatol, Vol: 7, Pages: 659-663
BACKGROUND & AIMS: Most patients with familial adenomatous polyposis (FAP) develop duodenal adenomas; duodenal cancer is a major cause of mortality in this patient group. We reviewed cases of duodenal cancer in patients with FAP to identify factors that determine long-term cancer risk. METHODS: Twenty FAP patients (12 male) were identified from a registry database search. Data from registry and medical notes and endoscopic and histopathologic reports were evaluated. RESULTS: Of the cancers that developed in these patients, 11 were ampullary and 9 were duodenal. The median age at cancer diagnosis was 53 years. Seventeen patients died (median age at death, 57 y; median survival from diagnosis, 11 mo); the cause of death was metastatic or duodenal/ampullary cancer in 14 patients. Fifteen patients presented symptomatically (including 3 interval cancers while on surveillance). Two were diagnosed at surveillance and 3 were diagnosed during surgery performed for endoscopic features of advanced benign disease. Duodenal cancers were associated with a significantly lower mean colonic polyp count than ampullary cancers (496 +/- 282 vs 1322 +/- 735; P = .025); there appeared to be familial clustering of this cancer. When endoscopic data were available (n = 11 of 20), all ampullary cancers arose from ampullas greater than 1 cm. The Spigelman stage did not predict risk of ampullary cancer but did predict duodenal cancer (median stage 2 vs stage 4 for duodenal cancer). CONCLUSIONS: Once cancer arises in patients with FAP, prognosis is poor, so cancer prevention should be the main goal. Surveillance intervals should reflect both Spigelman staging and ampullary disease.
McLaughlin SD, Clark SK, Tekkis PP, et al., 2009, <i>Clostridium difficile</i> and Extended Spectrum Beta-Lactamase Resistant Bacteria in UK Chronic Pouchitis Patients, Digestive Disease Week/110th Annual Meeting of the American-Gastroenterological-Association, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: A410-A410, ISSN: 0016-5085
Mann ER, Al-Hassi HO, Clark SK, et al., 2009, Imprinting of Lymphocyte Homing to Skin and Gut By Human Tissue DC, Digestive Disease Week/110th Annual Meeting of the American-Gastroenterological-Association, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: A408-A408, ISSN: 0016-5085
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- Citations: 1
Will OCC, Phillips RKS, Hyer W, et al., 2009, SYMPTOMATIC POLYPOSIS IN A 4-YEAR-OLD: THE EXCEPTION PROVES THE RULE, JOURNAL OF PAEDIATRICS AND CHILD HEALTH, Vol: 45, Pages: 320-321, ISSN: 1034-4810
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- Citations: 2
McLaughlin SD, Clark SK, Bell AJ, et al., 2009, Incidence and Short-Term Implications of Prepouch Ileitis Following Restorative Proctocolectomy with Ileal Pouch-Anal Anastomosis for Ulcerative Colitis, DISEASES OF THE COLON & RECTUM, Vol: 52, Pages: 879-883, ISSN: 0012-3706
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- Citations: 22
McLaughlin SD, Clark SK, Shafi S, et al., 2009, Fecal Coliform Testing to Identify Effective Antibiotic Therapies for Patients With Antibiotic-Resistant Pouchitis, CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, Vol: 7, Pages: 545-548, ISSN: 1542-3565
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- Citations: 38
McLaughlin SD, Clark SK, Tekkis PP, et al., 2009, Stool Coliform Testing Can Predict Effective Treatment Regimes for Patients with Antibiotic Resistant Pouchitis, Digestive Disease Week/110th Annual Meeting of the American-Gastroenterological-Association, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: A15-A15, ISSN: 0016-5085
McLaughlin SD, Culkin A, Clark SK, et al., 2009, Treatment with Elemental Improves Symptoms of Chronic Pouchitis Following Ileal Pouch-Anal Anastomosis for Ulcerative Colitis, Digestive Disease Week/110th Annual Meeting of the American-Gastroenterological-Association, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: A664-A664, ISSN: 0016-5085
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