Summary
Dr Toby Andrew is a Senior Lecturer in Human Genetics at the Department of Metabolism, Digestion and Reproduction, Imperial College, where he is a Principal Investigator and Programme Organiser for the MSc in Human Molecular Genetics.
Trained in Zoology and Physiology (BSc. Leeds 1985), Biological Computing & Statistics (MSc. York, 1989) and Human Genetics (PhD. King's College London, 2005) his research focuses on the genetics of metabolic disease and common myopia, with an emphasis on mitochondrial function. He was awarded a prestigious MRC New Investigator Award in 2010 and has published widely on the genetics of common disease and gene mapping methods.
Selected Publications
Journal Articles
Maude H, Lau W, Maniatis N, et al., 2021, New Insights Into Mitochondrial Dysfunction at Disease Susceptibility Loci in the Development of Type 2 Diabetes, Frontiers in Endocrinology, Vol:12, ISSN:1664-2392
Maude H, Davidson M, Charitakis N, et al., 2019, NUMT confounding biases mitochondrial heteroplasmy calls in favor of the reference allele, Frontiers in Cell and Developmental Biology, Vol:7, ISSN:2296-634X
Dalmia A, Dib M-J, Maude H, et al., 2019, A genetic epidemiological study in British adults and older adults shows a high heritability of the combined indicator of vitamin B12 status (cB12) and connects B12 status with utilization of mitochondrial substrates and energy metabolism, Journal of Nutritional Biochemistry, Vol:70, ISSN:0955-2863, Pages:156-163
Andrew T, Nash A, Mandaviya P, et al., 2018, Interaction between plasma homocysteine and the MTHFR c.677C>T polymorphism is associated with site-specific changes in DNA methylation in humans, The FASEB Journal, ISSN:0892-6638
Lau W, Andrew T, Maniatis N, 2017, High-Resolution Genetic Maps Identify Multiple Type 2 Diabetes Loci at Regulatory Hotspots in African Americans and Europeans, American Journal of Human Genetics, Vol:100, ISSN:0002-9297, Pages:803-816
Direk K, Lau W, Small KS, et al., 2014, ABCC5 Transporter is a Novel Type 2 Diabetes Susceptibility Gene in European and African American Populations, Annals of Human Genetics, Vol:78, Pages:333-344
Ahmadi KR, Andrew T, 2014, Opportunism: a panacea for implementation of whole-genome sequencing studies in nutrigenomics research?, Genes and Nutrition, Vol:9, ISSN:1555-8932, Pages:1-3
Andrew T, Gill R, Gillham-Nasenya I, et al., 2013, Unravelling the basis of variability in cobalamin levels in the general population, British Journal of Nutrition, Vol:110, ISSN:0007-1145, Pages:1672-1679
Direk K, Cecelja M, Astle W, et al., 2013, The relationship between DXA-based and anthropometric measures of visceral fat and morbidity in women, BMC Cardiovascular Disorders, Vol:13, ISSN:1471-2261
Andrew T, Calloway CD, Stuart S, et al., 2011, A Twin Study of Mitochondrial DNA Polymorphisms Shows that Heteroplasmy at Multiple Sites Is Associated with mtDNA Variant 16093 but Not with Zygosity, PLOS One, Vol:6, ISSN:1932-6203
Hysi PG, Young TL, Mackey DA, et al., 2010, A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25, Nature Genetics, Vol:42, ISSN:1061-4036, Pages:902-+
Andrew T, Maniatis N, Carbonaro F, et al., 2008, Identification and Replication of Three Novel Myopia Common Susceptibility Gene Loci on Chromosome 3q26 using Linkage and Linkage Disequilibrium Mapping, PLOS Genetics, Vol:4, ISSN:1553-7390