Publications
97 results found
Andrew T, 2010, The genetic epidemiology of osteoporosis using intermediate phenotypes measured in healthy aging female twins.
Carbonaro F, Andrew T, Mackey DA, et al., 2009, Repeated Measures of Intraocular Pressure Result in Higher Heritability and Greater Power in Genetic Linkage Studies, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 50, Pages: 5115-5119, ISSN: 0146-0404
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- Citations: 24
Kettunen J, Perola M, Martin NG, et al., 2009, Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci, INTERNATIONAL JOURNAL OF OBESITY, Vol: 33, Pages: 1235-1242, ISSN: 0307-0565
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- Citations: 20
Jun G, Guo H, Klein BEK, et al., 2009, <i>EPHA2</i> Is Associated with Age-Related Cortical Cataract in Mice and Humans, PLOS GENETICS, Vol: 5, ISSN: 1553-7404
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- Citations: 114
Rahmioglu N, Andrew T, Cherkas L, et al., 2009, Epidemiology and Genetic Epidemiology of the Liver Function Test Proteins, PLOS ONE, Vol: 4, ISSN: 1932-6203
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- Citations: 48
Lopes MC, Andrew T, Carbonaro F, et al., 2009, Estimating Heritability and Shared Environmental Effects for Refractive Error in Twin and Family Studies, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 50, Pages: 126-131, ISSN: 0146-0404
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- Citations: 99
Zhai G, Andrew T, Kato BS, et al., 2009, Genetic and environmental determinants on bone loss in postmenopausal Caucasian women: a 14-year longitudinal twin study, Osteoporos.Int., Vol: 20, Pages: 949-953, ISSN: 1433-2965
SUMMARY: This longitudinal twin study documented that genetic factors explain 44-56% of the between-individual variance in bone loss at femoral neck, lumbar spine, and forearm in postmenopausal Caucasian women, providing a rationale for identifying the specific genes involved. INTRODUCTION: Although there is a significant genetic effect on peak BMD, until recently, no substantive studies on heritability of bone loss in human were available. The aim of the study was to estimate the heritability of the bone loss at multiple sites in postmenopausal Caucasian women. METHODS: Postmenopausal female monozygotic (MZ) and dizygotic (DZ) twins aged 40 or above at baseline were selected from the TwinsUK registry and followed up for an average of 8 years (range 5-14 years). All twins were noncurrent hormone replacement therapy users and not on any osteoporosis treatment. They had dual-energy X-ray absorptiometry (DXA) scans of their hip, lumbar spine, and forearm several times (range 2-9) during the follow-up period. Individual bone losses at femoral neck, lumbar spine, and forearm were estimated by linear regression modeling. Structural equation modeling was utilized to estimate the heritability of the bone loss. RESULTS: A total of 712 postmenopausal Caucasian female twins (152 MZ and 204 DZ pairs) were included. MZ twins were older and had slightly lower BMD at all sites than DZ twins. DZ twins had slightly higher bone loss at lumbar spine, but similar at femoral neck and forearm compared to MZ twins. Intraclass correlation coefficients (ICC) for the bone loss at all sites were significantly higher in MZ than DZ twin pairs (p = 0.0045, 0.0003, and 0.0007 for femoral neck, lumbar spine, and forearm, respectively), indicating a significant genetic influence on bone loss at these sites. After adjustment for age at baseline and weight change during the follow-up, the heritability estimate was 47% (95% CI 27-63%) for bone loss at femoral neck, 44% (95% CI 27-58%) for lumbar spine
Andrew T, Maniatis N, Carbonaro F, et al., 2008, Identification and Replication of Three Novel Myopia Common Susceptibility Gene Loci on Chromosome 3q26 using Linkage and Linkage Disequilibrium Mapping, PLOS GENETICS, Vol: 4, ISSN: 1553-7390
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- Citations: 56
Tachmazidou I, Andrew T, Verzilli CJ, et al., 2008, Bayesian survival analysis in genetic association studies, Bioinformatics, Vol: 24, Pages: 2030-2036, ISSN: 1367-4803
Motivation: Large-scale genetic association studies are carried out with the hope of discovering single nucleotide polymorphisms involved in the etiology of complex diseases. There are several existing methods in the literature for performing this kind of analysis for case-control studies, but less work has been done for prospective cohort studies. We present a Bayesian method for linking markers to censored survival outcome by clustering haplotypes using gene trees. Coalescent-based approaches are promising for LD mapping, as the coalescent offers a good approximation to the evolutionary history of mutations.Results: We compare the performance of the proposed method in simulation studies to the univariate Cox regression and to dimension reduction methods, and we observe that it performs similarly in localizing the causal site, while offering a clear advantage in terms of false positive associations. Moreover, it offers computational advantages. Applying our method to a real prospective study, we observe potential association between candidate ABC transporter genes and epilepsy treatment outcomes.
Richards J, Rivadeneira F, Inouye M, et al., 2008, Genome-Wide Association Study Reveals Genetic Variants Associated with Bone Mineral Density, Osteoporosis and Osteoporotic Fractures, 30th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, Publisher: AMER SOC BONE & MINERAL RES, Pages: S184-S184, ISSN: 0884-0431
Carbonaro F, Andrew T, Mackey DA, et al., 2008, The heritability of corneal hysteresis and ocular pulse amplitude - A twin study, OPHTHALMOLOGY, Vol: 115, Pages: 1545-1549, ISSN: 0161-6420
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- Citations: 50
Carbonaro F, Andrew T, Mackey DA, et al., 2008, Heritability of intraocular pressure: a classical twin study, BRITISH JOURNAL OF OPHTHALMOLOGY, Vol: 92, Pages: 1125-1128, ISSN: 0007-1161
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- Citations: 26
Richards JB, Rivadeneira F, Inouye M, et al., 2008, Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study, LANCET, Vol: 371, Pages: 1505-1512, ISSN: 0140-6736
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- Citations: 513
Visscher PM, Andrew T, Nyholt DR, 2008, Genome-wide association studies of quantitative traits with related individuals: little (power) lost but much to be gained, EUROPEAN JOURNAL OF HUMAN GENETICS, Vol: 16, Pages: 387-390, ISSN: 1018-4813
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- Citations: 37
Leschziner GD, Jorgensen AL, Andrews T, et al., 2007, The association between polymorphisms in <i>RLIP76</i> and drug response in epilepsy, PHARMACOGENOMICS, Vol: 8, Pages: 1715-1722, ISSN: 1462-2416
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- Citations: 13
Clark TG, Andrew T, Cooper GM, et al., 2007, Functional constraint and small insertions and deletions in the ENCODE regions of the human genome., Genome Biol, Vol: 8, Pages: R180-R180, ISSN: 1465-6914
ABSTRACT: BACKGROUND: We describe the distribution of indels in the 44 Encyclopedia of DNA Elements (ENCODE) regions (about 1% of the human genome) and evaluate the potential contributions of small insertion and deletion polymorphisms (indels) to human genetic variation. We relate indels to known genomic annotation features and measures of evolutionary constraint. RESULTS: Indel rates are observed to be reduced approximately 20-fold to 60-fold in exonic regions, 5-fold to 10-fold in sequence that exhibits high evolutionary constraint in mammals, and up to 2-fold in some classes of regulatory elements (for instance, formaldehyde assisted isolation of regulatory elements [FAIRE] and hypersensitive sites). In addition, some noncoding transcription and other chromatin mediated regulatory sites also have reduced indel rates. Overall indel rates for these data are estimated to be smaller than single nucleotide polymorphism (SNP) rates by a factor of approximately 2, with both rates measured as base pairs per 100 kilobases to facilitate comparison. CONCLUSION: Indel rates exhibit a broadly similar distribution across genomic features compared with SNP density rates, with a reduction in rates in coding transcription and evolutionarily constrained sequence. However, unlike indels, SNP rates do not appear to be reduced in some noncoding functional sequences, such as pseudo-exons, and FAIRE and hypersensitive sites. We conclude that indel rates are greatly reduced in transcribed and evolutionarily constrained DNA, and discuss why indel (but not SNP) rates appear to be constrained at some regulatory sites.
Leschziner GD, Andrew T, Pirmohamed M, et al., 2007, <i>ABCB1</i> genotype and PGP expression, function and therapeutic drug response:: a critical review and recommendations for future research, PHARMACOGENOMICS JOURNAL, Vol: 7, Pages: 154-179, ISSN: 1470-269X
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- Citations: 213
Leschziner GD, Andrew T, Leach JP, et al., 2007, Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach, PHARMACOGENETICS AND GENOMICS, Vol: 17, Pages: 217-220, ISSN: 1744-6872
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- Citations: 40
Ioannidis JPA, Ng MY, Sham PC, et al., 2007, Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass, JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 22, Pages: 173-183, ISSN: 0884-0431
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- Citations: 134
Leschziner G, Jorgensen A, Andrew T, et al., 2006, ABCB1 polymorphisms and haplotype previously associated with drug resistant epilepsy have no effect on therapeutic or adverse drug response in a large prospective epilepsy cohort, Spring Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: 1394-1394, ISSN: 0022-3050
Ioannidis JP, Ng MY, Sham PC, et al., 2006, Meta-Analysis of Genome Wide Scans Provides Evidence for Gender and Site Specific Regulation of Bone Mass., J Bone Miner Res, ISSN: 0884-0431
Microabstract Several genome wide scans have been performed to detect loci that regulate bone mineral density (BMD) but these have yielded inconsistent results, with limited replication of linkage peaks in different studies. In an effort to improve statistical power for detection of these loci we performed a meta-analysis of genome wide scans in which spine or hip BMD were studied. Evidence was gained to suggest that several chromosomal loci regulate BMD in a site specific and gender specific manner.
Leschziner G, Jorgensen AL, Andrew T, et al., 2006, Clinical factors and <i>ABCB1</i> polymorphisms in prediction of antiepileptic drug response:: a prospective cohort study, LANCET NEUROLOGY, Vol: 5, Pages: 668-676, ISSN: 1474-4422
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- Citations: 54
de lange M, Andrew T, Snieder H, et al., 2006, Joint linkage and association of six single-nucleotide polymorphisms in the factor XIII-A subunit gene point to V34L as the main functional locus, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 26, Pages: 1914-1919, ISSN: 1079-5642
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- Citations: 22
Williams FMK, Andrew T, Saxne T, et al., 2006, The heritable determinants of cartilage oligomeric matrix protein, ARTHRITIS AND RHEUMATISM, Vol: 54, Pages: 2147-2151, ISSN: 0004-3591
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- Citations: 13
Paul SN, Kato BS, Cherkas LF, et al., 2006, Heritability of the Second to Fourth Digit Ratio (2d:4d): A Twin Study, Twin Research and Human Genetics, Vol: 9, Pages: 215-219, ISSN: 1832-4274
Paul SN, Kato BS, Cherkas LF, et al., 2006, Heritability of the second to fourth digit ratio (2d:4d):: A twin study, TWIN RESEARCH AND HUMAN GENETICS, Vol: 9, Pages: 215-219, ISSN: 1832-4274
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- Citations: 84
Wilson SG, Adam G, Langdown M, et al., 2006, Linkage and potential association of obesity-related phenotypes with two genes on chromosome 12q24 in a female dizygous twin cohort, EUROPEAN JOURNAL OF HUMAN GENETICS, Vol: 14, Pages: 340-348, ISSN: 1018-4813
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- Citations: 54
Sharma P, Middelberg RPS, Andrew T, et al., 2006, Heritability of left ventricular mass in a large cohort of twins, JOURNAL OF HYPERTENSION, Vol: 24, Pages: 321-324, ISSN: 0263-6352
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- Citations: 46
Sharma P, Middelberg RPS, Andrew T, et al., 2006, Heritability of left ventricular mass in a large cohort of twins, Journal of Hypertension, Vol: 24, Pages: 321-324, ISSN: 0263-6352
Introduction: Left ventricular hypertrophy is recognized as one of the most important independent predictors of adverse cardiovascular outcome. The aetiology of LVH includes a number of well-recognized causes but there is considerable interest in the genetics of cardiac muscle hypertrophy. We used a large prospective twin database in order to establish the heritability of left ventricular mass (LVM). Methods: Normotensive twins were prospectively recruited. Demographic data were collected. The LVM was determined using the Penn formulae derived from data collected from echocardiography. Results: A total of 376 Caucasian twin pairs (182 monozygotic and 194 dizygotic) aged 25-79 years were recruited. All subjects were normotensive with no significant differences in blood pressure (mean blood pressure: monozygotic twins, 132/83 mmHg; dizygotic twins, 131/ 82 mmHg) or body mass index between the monozygotic and dizygotic twins. The mean LVM for monozygotic twins was 140.9 g, compared with 140.2 g for dizygotic twins. Heritability estimates suggest that the genetic variance of LVM is 0.59 (95% confidence interval, 0.5-0.67). No common shared environmental effects were identified under this model. Conclusion: Our data from the largest set of twin pairs studied to date show that LVM has a sizeable genetic basis that is probably polygenic. This result has important implications for the understanding of normal and abnormal cardiac morphology at the molecular level. © 2006 Lippincott Williams & Wilkins.
Leschziner GD, Jorgensen A, Andrew T, et al., 2006, ACB1 polymorphisms and haplotype previously associated with drug-resistant epilepsy have no effect on therapeutic or adverse drug response in a large prospective cohort, 9th European Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX), Publisher: TAYLOR & FRANCIS INC, Pages: 84-84, ISSN: 0360-2532
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