Imperial College London
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Professor Thanos Athanasiou MD PhD MBA FECTS FRCS

Faculty of Medicine, Department of Surgery & Cancer

Professor of Cardiovascular Sciences
 
 
 
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Contact

 

t.athanasiou

 
 
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Location

 

1022Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fergadi:2021:10.1007/s00261-021-03096-7,
author = {Fergadi, MP and Magouliotis, DE and Vlychou, M and Rountas, C and Athanasiou, T and Zacharoulis, D},
doi = {10.1007/s00261-021-03096-7},
journal = {Abdom Radiol (NY)},
pages = {4178--4188},
title = {A meta-analysis evaluating contrast-enhanced intraoperative ultrasound (CE-IOUS) in the context of surgery for colorectal liver metastases.},
url = {http://dx.doi.org/10.1007/s00261-021-03096-7},
volume = {46},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: This study aimed to assess the outcomes of contrast-enhanced intraoperative ultrasound (CE-IOUS) for patients with colorectal liver metastases (CRLMs) undergoing surgery. METHOD: A thorough literature search was performed in PubMed, Scopus, and Cochrane databases, in accordance with the PRISMA guidelines. The Odds Ratio, Weighted Mean Difference, and 95% Confidence Interval were evaluated, by means of Random-Effects model. RESULTS: Eleven articles met the inclusion criteria and incorporated 497 patients. The present study shows that CE-IOUS is associated with higher sensitivity and accuracy compared with multidetector computed tomography (MDCT), magnetic resonance imaging (MRI), and intraoperative ultrasound (IOUS) in identifying CRLMs (p < 0.05). The positive predictive value was similar among the different modalities. Furthermore, new CRLMs were identified by CE-IOUS, thus affecting the surgical plan in 128 patients (51.8% of the patients with new CRLMs). Moreover, 91 patients (71%) underwent a more extensive hepatectomy and 15 patients (11.7%) were considered non-operable. Two alternative contrast agents, Sonazoid and Sonovue, were employed with similar sensitivity (p > 0.05). CONCLUSION: These outcomes suggest the superiority of the CE-IOUS over MDCT, MRI, and IOUS for the staging of patients with CRLMs undergoing surgery. However, they should be treated with caution given the small number of the included studies.
AU  - Fergadi,MP
AU  - Magouliotis,DE
AU  - Vlychou,M
AU  - Rountas,C
AU  - Athanasiou,T
AU  - Zacharoulis,D
DO  - 10.1007/s00261-021-03096-7
EP  - 4188
PY  - 2021///
SP  - 4178
TI  - A meta-analysis evaluating contrast-enhanced intraoperative ultrasound (CE-IOUS) in the context of surgery for colorectal liver metastases.
T2  - Abdom Radiol (NY)
UR  - http://dx.doi.org/10.1007/s00261-021-03096-7
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33969446
VL  - 46
ER  -
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