Imperial College London
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Professor Thanos Athanasiou MD PhD MBA FECTS FRCS

Faculty of Medicine, Department of Surgery & Cancer

Professor of Cardiovascular Sciences
 
 
 
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Contact

 

t.athanasiou

 
 
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Location

 

1022Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Salmasi:2021:10.1177/02676591211037577,
author = {Salmasi, MY and Ravishankar, R and Abdullahi, Y and Hartley, P and Kyriazis, PG and Athanasiou, T and Punjabi, P},
doi = {10.1177/02676591211037577},
journal = {Perfusion},
pages = {75--84},
title = {Predictors of outcome after CABG in the South-Asian community: a propensity matched analysis},
url = {http://dx.doi.org/10.1177/02676591211037577},
volume = {38},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:Ethnicity is not incorporated into standardized pre-operative risk-stratification tools for cardiac surgery. This study compared short-term outcomes following coronary artery bypass graft (CABG) surgery in South Asian and non-Asian patients.Methods:Consecutive patients undergoing isolated CABG surgery via sternotomy between the years 2011 and 2019 were retrospectively analyzed. Initially, 1957 patients were identified (799 South-Asian, 40.8%). The patient groups were then propensity matched according to 10 relevant pre-operative covariates (age, body mass index, pulmonary disease, renal failure, smoking, diabetes, ventricular function, renal failure): 675 non-Asian patients were matched against 675 Asian patients.Results:Operative mortality was 1.77% and similar between the two groups (p = 0.447). Multivariate regression analysis found predictors of operative mortality to be pre-operative serum creatinine, age, left ventricular (LV) impairment, and extent of coronary disease. The effect of creatinine on mortality was selective for South-Asian patients (p = 0.015). LV impairment was a predictor of mortality in non-Asian patients, however this effect did not exist in South-Asian patients. Predictors of short-term complications (composite of death, stroke, reoperation, hemofiltration, and pneumonia) were age and creatinine (coefficient 0.002, 95% CI 0.0004–0.004, p = 0.019) in the overall cohort. Subgroup analysis found age to remain a selective negative predictor of complications in South-Asian patients. Cox regression analysis found creatinine, age, and LVEF to influence 10-year survival, whilst ethnicity was not a predictor.Conclusion:This study highlights the cumulative risk associated with ethnicity and renal disease in predicting short-term outcomes following CABG. This warrants further investigations in larger populations, thus guiding pre-operative risk-stratification.
AU  - Salmasi,MY
AU  - Ravishankar,R
AU  - Abdullahi,Y
AU  - Hartley,P
AU  - Kyriazis,PG
AU  - Athanasiou,T
AU  - Punjabi,P
DO  - 10.1177/02676591211037577
EP  - 84
PY  - 2021///
SN  - 0267-6591
SP  - 75
TI  - Predictors of outcome after CABG in the South-Asian community: a propensity matched analysis
T2  - Perfusion
UR  - http://dx.doi.org/10.1177/02676591211037577
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000683933800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://journals.sagepub.com/doi/10.1177/02676591211037577
UR  - http://hdl.handle.net/10044/1/103023
VL  - 38
ER  -
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