Imperial College London
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Professor Thanos Athanasiou MD PhD MBA FECTS FRCS

Faculty of Medicine, Department of Surgery & Cancer

Professor of Cardiovascular Sciences
 
 
 
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Contact

 

t.athanasiou

 
 
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Location

 

1022Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Monteagudo-Vela:2022:10.1111/aor.14186,
author = {Monteagudo-Vela, M and Krasopoulos, G and Athanasiou, T and Tsui, S and Kourliouros, A},
doi = {10.1111/aor.14186},
journal = {Artif Organs},
pages = {1012--1018},
title = {Impact of third-generation left ventricular assist devices on quality of life: Scoping review and meta-analysis.},
url = {http://dx.doi.org/10.1111/aor.14186},
volume = {46},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVES: Development in device technology and the scarcity of donor's hearts have increased the number of patients with advanced heart failure receiving durable left ventricular assist devices (LVADs) as a bridge to transplantation and destination therapy, with improved prognosis compared with guideline-directed medical therapy. We sought to examine the impact of modern durable LVADs on the quality of life (QoL) of the recipients. METHODS: We carried out a systematic review of articles on QoL following the implantation of third-generation LVADs published between January 2010 and February 2021. Included studies were critically analyzed and evidence synthesis was carried out into a meta-analysis. RESULTS: The systematic search yielded 269 articles, 11 of which met the search predefined criteria. Three of them reported results of randomized trials and eight were retrospective and registry studies. Statistically significant QoL improvement from baseline was observed in all published reports. When using the EuroQol 5L questionnaire (scale 0-100) as a QoL tool 6 months post-LVAD implantation, a meta-analysis of four included studies demonstrated a mean difference increase of 28.9 points (95% confidence interval: 26.71-31.14). CONCLUSIONS: Third-generation LVADs confer a significant improvement in QoL and their use can be supported not only for prognosis but also for symptom control. Although methodological limitations should be considered, the available QoL outcomes can be a useful tool in patient selection and the decision-making process.
AU  - Monteagudo-Vela,M
AU  - Krasopoulos,G
AU  - Athanasiou,T
AU  - Tsui,S
AU  - Kourliouros,A
DO  - 10.1111/aor.14186
EP  - 1018
PY  - 2022///
SP  - 1012
TI  - Impact of third-generation left ventricular assist devices on quality of life: Scoping review and meta-analysis.
T2  - Artif Organs
UR  - http://dx.doi.org/10.1111/aor.14186
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35132647
VL  - 46
ER  -
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