Imperial College London
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Professor Thanos Athanasiou MD PhD MBA FECTS FRCS

Faculty of Medicine, Department of Surgery & Cancer

Professor of Cardiovascular Sciences
 
 
 
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Contact

 

t.athanasiou

 
 
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Location

 

1022Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Salmasi:2023:10.1016/j.hjc.2022.09.009,
author = {Salmasi, MY and Alwis, S and Cyclewala, S and Jarral, OA and Mohamed, H and Mozalbat, D and Nienaber, CA and Athanasiou, T and Morris-Rosendahl, D and Members, of the London Aortic Mechanobiology Working Group},
doi = {10.1016/j.hjc.2022.09.009},
journal = {Hellenic Journal of Cardiology},
pages = {41--50},
title = {The genetic basis of thoracic aortic disease: The future of aneurysm classification?},
url = {http://dx.doi.org/10.1016/j.hjc.2022.09.009},
volume = {69},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The expansion in the repertoire of genes linked to thoracic aortic aneurysms (TAA) has revolutionised our understanding of the disease process. The clinical benefits of such progress are numerous, particularly helping our understanding of non-syndromic hereditary causes of TAA (HTAAD) and further refinement in the subclassification of disease. Furthermore, the understanding of aortic biomechanics and mechanical homeostasis has been significantly informed by the discovery of deleterious mutations and their effect on aortic phenotype. The drawbacks in genetic testing in TAA lie with the inability to translate genotype to accurate prognostication in the risk of thoracic aortic dissection (TAD), which is a life-threatening condition. Under current guidelines, there are no metrics by which those at risk for dissection with normal aortic diameters may undergo preventive surgery. Future research lies with more advanced genetic diagnosis of HTAAD and investigation of the diverse pathways involved in its pathophysiology, which will i) serve to improve our understanding of the underlying mechanisms, ii) improve guidelines for treatment and iii) prevent complications for HTAAD and sporadic aortopathies.
AU  - Salmasi,MY
AU  - Alwis,S
AU  - Cyclewala,S
AU  - Jarral,OA
AU  - Mohamed,H
AU  - Mozalbat,D
AU  - Nienaber,CA
AU  - Athanasiou,T
AU  - Morris-Rosendahl,D
AU  - Members,of the London Aortic Mechanobiology Working Group
DO  - 10.1016/j.hjc.2022.09.009
EP  - 50
PY  - 2023///
SN  - 1109-9666
SP  - 41
TI  - The genetic basis of thoracic aortic disease: The future of aneurysm classification?
T2  - Hellenic Journal of Cardiology
UR  - http://dx.doi.org/10.1016/j.hjc.2022.09.009
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36202327
UR  - https://www.sciencedirect.com/science/article/pii/S1109966622001427?via%3Dihub
UR  - http://hdl.handle.net/10044/1/102161
VL  - 69
ER  -
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