Imperial College London
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Professor Thanos Athanasiou MD PhD MBA FECTS FRCS

Faculty of Medicine, Department of Surgery & Cancer

Professor of Cardiovascular Sciences
 
 
 
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Contact

 

t.athanasiou

 
 
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Location

 

1022Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Magouliotis:2023:10.1007/s11748-022-01891-7,
author = {Magouliotis, DE and Fergadi, MP and Zotos, P-A and Rad, AA and Xanthopoulos, A and Bareka, M and Spiliopoulos, K and Athanasiou, T},
doi = {10.1007/s11748-022-01891-7},
journal = {Gen Thorac Cardiovasc Surg},
pages = {77--89},
title = {Differences in long-term survival outcomes after coronary artery bypass grafting using single vs multiple arterial grafts: a meta-analysis with reconstructed time-to-event data and subgroup analyses.},
url = {http://dx.doi.org/10.1007/s11748-022-01891-7},
volume = {71},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: We reviewed the available literature on patients with coronary artery disease undergoing isolated coronary artery bypass grafting (CABG) with either single (SAG) or multiple arterial grafting (MAG). METHODS: Original research studies that evaluated the long-term survival of MAG versus SAG were identified, from 1995 to 2022. The median overall survival (OS) and event-free OS were the primary endpoints. Comparison of median OS between the right internal mammary artery (RIMA) and radial artery (RA) as a second arterial conduit was the secondary endpoint. Subgroup analyses were performed regarding patients older than 70 years, with diabetes mellitus, and females. A sensitivity analysis was performed with the leave-one-out method. RESULTS: Forty-four studies were included in the qualitative and thirty-nine in the quantitative synthesis. After pooling data from 180 to 459 patients, the MAG group demonstrated a higher OS (HR, 0.589; 95% CI, 0.58-0.60; p < 0.0001) and event-free OS compared with the SAG group (HR, 0.828; 95% CI, 0.80-0.86; p < 0.0001). In addition, RITA was associated with superior OS compared with RA as a second arterial conduit (HR, 0.936; 95% CI, 0.89-0.98; p = 0.009). MAG was also superior to SAG in patients over 70 years, females, and patients with diabetes mellitus. Sensitivity analysis demonstrated a small-size study effect on the female subgroup analysis. CONCLUSION: The present meta-analysis indicates that MAG is associated with enhanced survival outcomes compared to SAG for patients undergoing isolated CABG.
AU  - Magouliotis,DE
AU  - Fergadi,MP
AU  - Zotos,P-A
AU  - Rad,AA
AU  - Xanthopoulos,A
AU  - Bareka,M
AU  - Spiliopoulos,K
AU  - Athanasiou,T
DO  - 10.1007/s11748-022-01891-7
EP  - 89
PY  - 2023///
SP  - 77
TI  - Differences in long-term survival outcomes after coronary artery bypass grafting using single vs multiple arterial grafts: a meta-analysis with reconstructed time-to-event data and subgroup analyses.
T2  - Gen Thorac Cardiovasc Surg
UR  - http://dx.doi.org/10.1007/s11748-022-01891-7
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36394709
VL  - 71
ER  -
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