Publications
109 results found
Sharma R, Wang WM, Evans J, et al., 2017, 68Ga-DOTATATE PET/CT to predict response to peptide receptor radionuclide therapy (PRRT) in neuroendocrine tumours (NETs), ASCO, Publisher: American Society of Clinical Oncology, ISSN: 0732-183X
Lakhani A, Khan SR, Bharwani N, et al., 2017, FDG PET/CT Pitfalls in Gynecologic and Genitourinary Oncologic Imaging., Radiographics, Vol: 37, Pages: 577-594
The role of whole-body positron emission tomography (PET)/computed tomography (CT) with fluorodeoxyglucose ( FDG fluorodeoxyglucose ) is now established in the assessment of many gynecologic and genitourinary malignant tumors. FDG fluorodeoxyglucose PET/CT has been widely adopted for staging assessments in patients with suspected advanced disease, in cases of suspected disease recurrence, and for determining prognosis in a number of malignancies. A number of pitfalls are commonly encountered when reviewing FDG fluorodeoxyglucose PET/CT scans in gynecologic and genitourinary cases; these pitfalls can be classified into those that yield potential false-positive or false-negative results. Potential false positives include physiologic uptake of FDG fluorodeoxyglucose by the endometrium and ovaries in premenopausal patients, physiologic renal excretion of FDG fluorodeoxyglucose into the ureters and the urinary bladder, and increased FDG fluorodeoxyglucose activity in benign conditions such as uterine fibroids, pelvic inflammatory disease, and benign endometriotic cysts. Potential false negatives include low-level FDG fluorodeoxyglucose uptake by necrotic, mucinous, cystic, or low-grade tumors and the masking of serosal and peritoneal disease by adjacent physiologic bowel or bladder activity. In addition, there are inherent technical limitations-such as motion artifact (from respiratory motion and bowel peristalsis) and the limited spatial resolution of PET-that may limit the assessment of small-volume malignant disease. Knowledge of the key imaging features of physiologic and nonphysiologic FDG fluorodeoxyglucose uptake, in addition to understanding the principles of adequate patient preparation and PET scanning protocols, is important for accurate interpretation of gynecologic and genitourinary oncologic FDG fluorodeoxyglucose PET/CT studies. ©RSNA, 2017.
Youngstein T, Tombetti E, Mukherjee J, et al., 2017, FDG uptake by prosthetic arterial grafts in large vessel vasculitis Is not specific for active disease, JACC: Cardiovascular Imaging, Vol: 10, Pages: 1042-1052, ISSN: 1936-878X
OBJECTIVES: This study investigated the incidence and clinical significance of arterial graft-associated uptake of fluorodeoxyglucose in large-vessel vasculitis (LVV). BACKGROUND: The role of (18)F-labeled fluorodeoxyglucose-positron emission tomography/computed tomography ([(18)F]FDG-PET/CT) in the management of LVV remains to be defined. Although [(18)F]FDG uptake at arterial graft sites raises concerns regarding active arteritis or infection, its clinical significance in LVV has never been formally studied. METHODS: An observational prospective study sought to identify patients with Takayasu arteritis (TA) undergoing [(18)F]FDG-PET/CT more than 6 months after graft surgery from a large cohort of patients from 2 tertiary referral centers. [(18)F]FDG uptake by the graft and native arteries was scored on a scale of 0 to 3 relative to hepatic uptake, and periprosthetic maximum standardized uptake value (SUVmax) was calculated. Periprosthetic [(18)F]FDG uptake in active disease was compared with that in inactive disease, and arterial progression was assessed by prospective magnetic resonance angiography (MRA). RESULTS: Twenty-six subjects with TA were enrolled. All were afebrile with negative blood culture. Periprosthetic uptake was significant in 23 of 26 patients, and the mean SUVmax was 4.21 ± 1.46. Median periprosthetic [(18)F]FDG uptake score (3; interquartile range [IQR]: 3 to 3) was higher than in native aorta (1; IQR: 0 to 1; p < 0.001). Graft-specific [(18)F]FDG uptake was unrelated to disease activity. Despite the high frequency of graft-associated [(18)F]FDG uptake, sequential MRAs did not reveal arterial progression in 25 of 26 patients; the 1 remaining case showed minor progression limited to native arteries. Nine patients underwent repeated PET/CT scanning without showing changes in graft-specific uptake, despite increased treatment. CONCLUSIONS: Significant [(18)F]FDG uptake that is confined to arterial graft sites in patients w
Lyons OTA, Baguneid M, Barwick TD, et al., 2016, Diagnosis of Aortic Graft Infection: A Case Definition by the Management of Aortic Graft Infection Collaboration (MAGIC), EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 52, Pages: 758-763, ISSN: 1078-5884
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- Citations: 157
Sharma R, Mapelli P, Hanna GB, et al., 2016, Evaluation of F-18-fluorothymidine positron emission tomography ([F-18] FLT-PET/CT) methodology in assessing early response to chemotherapy in patients with gastro-oesophageal cancer, EJNMMI Research, Vol: 6, ISSN: 2191-219X
Background3’-Deoxy-3’-[18F]fluorothymidine ([18F]FLT) PET has limited utility in abdominal imaging due to high physiological hepatic uptake of a tracer. We evaluated [18F]FLT-PET/CT combined with a temporal-intensity information-based voxel-clustering approach termed kinetic spatial filtering (KSF) to improve tumour visualisation in patients with locally advanced and metastatic gastro-oesophageal cancer and as a marker of early response to chemotherapy.Dynamic [18F]FLT-PET/CT data were collected before and 3 weeks post first cycle of chemotherapy. Changes in tumour [18F]FLT-PET/CT variables were determined. Response was determined on contrast-enhanced CT after three cycles of therapy using RECIST 1.1.ResultsTen patients were included. Following application of the KSF, visual distinction of all oesophageal and/or gastric tumours was observed in [18F]FLT-PET images. Among the nine patients available for response evaluation (RECIST 1.1), three patients had responded (partial response) and six patients were non-responders (stable disease). There was a significant association between Ki-67 and all baseline [18F]FLT-PET parameters. Area under the curve (AUC) from 0 to 1 min was associated with treatment response.ConclusionsThe results of this study indicate that application of the KSF allowed accurate visualisation of both primary and metastatic lesions following imaging with the proliferation marker, [18F]FLT-PET/CT. However, [18F]FLT-PET uptake parameters did not correlate with response. Instead, we observe significant changes in tracer delivery following chemotherapy suggesting that further [18F]FLT-PET/CT studies in this tumour type should be undertaken with caution.
Khan SR, Patel NH, Wallitt KL, et al., 2016, First experience of 100 clinical F-18 florbetapir (Amyvid) PET/CT scans in the investigation of cognitive impairment: imaging characteristics, inter-observer agreement, confidence of read and clinical outcomes, Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), Publisher: Springer Verlag, Pages: S624-S624, ISSN: 1619-7070
Fakhry-Darian D, Khan SR, Patel NH, et al., 2016, Agreement Between Automatic Quantification and Experienced Reviewers in the Reporting of Amyvid PET/CT Scans, Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), Publisher: SPRINGER, Pages: S82-S82, ISSN: 1619-7070
Henderson LA, Pasternicki R, Maria R, et al., 2016, A Guide to Setting up a Ga68-PSMA PET/CT Service in the United Kingdom, Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), Publisher: SPRINGER, Pages: S671-S671, ISSN: 1619-7070
Grech-Sollars M, Ordidge KL, Vaqas B, et al., 2016, <SUP>18</SUP>F-fluoromethylcholine (FMC) PET/CT and proton magnetic resonance spectroscopy; imaging and tissue biomarkers of cell membrane turnover in primary brain gliomas - a pilot study, Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), Publisher: SPRINGER, Pages: S195-S195, ISSN: 1619-7070
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- Citations: 1
Dubash SR, Keat N, Mapelli P, et al., 2016, Biodistribution, radiation dosimetry and first preliminary results of a novel <SUP>18</SUP>F-fluoroethyl triazole [Tyr<SUP>3</SUP>] octreotate analogue for PET imaging in locally advanced and metastatic Neuroendocrine tumour patients, Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), Publisher: SPRINGER, Pages: S105-S105, ISSN: 1619-7070
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- Citations: 1
Youngstein T, Tombetti E, Mukherjee J, et al., 2016, 18F-FDG uptake by prosthetic arterial grafts in large vessel vasculitis is not specific for active disease: results from a cohort study, JACC: Cardiovascular Imaging, ISSN: 1876-7591
Objectives: To investigate the incidence and clinical significance of arterial graft-associated uptakeof fluorodeoxyglucose in large vessel vasculitis (LVV).Background: The role of [18F]-fluorodeoxyglucose-positron emission tomography/computedtomography (18F-FDG-PET/CT) in the management of LVV remains to be defined. Although 18FFDGuptake at arterial graft sites raises concerns regarding active arteritis or infection, its clinicalsignificance in LVV has never been formally studied.Methods: An observational prospective study sought to identify patients with Takayasu arteritis(TA) undergoing 18F-FDG-PET/CT more than 6 months after graft surgery, from a large cohort ofpatients from two tertiary referral centres. 18F-FDG uptake by the graft and native arteries wasscored on a 0 to 3 scale against hepatic uptake, and peri-prosthetic maximum standardized uptakevalue (SUVmax) was calculated. Peri-prosthetic 18F-FDG uptake in active or inactive disease wascompared and arterial progression was assessed by prospective magnetic resonance angiography(MRA).Results: Twenty-six subjects with TA were enrolled. All were afebrile with negative blood culture.Peri-prosthetic uptake was significant in 23/26 patients, with a mean SUVmax of 4.21±1.46. Medianperi-prosthetic 18F-FDG uptake score (3, IQR 3-3) was higher than in the native aorta (1, IQR 0-1,p<0.001). Graft-specific 18F-FDG uptake was unrelated to disease activity. Despite the highfrequency of graft-associated 18F-FDG uptake, sequential MRAs did not reveal arterial progressionin 25/26 patients; the remaining case showed minor progression limited to native arteries. Ninepatients repeated PET/CT scanning without changes in graft-specific uptake despite increasedtreatment.Conclusion: Significant 18F-FDG uptake confined to arterial graft sites in patients with LVV doesnot reflect clinically relevant disease activity or progression. To minimise exposure toimmunosuppression and in the face of negative blood culture, clinica
Khan SR, Rockall AG, Barwick TD, 2016, Molecular imaging in cervical cancer, QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 60, Pages: 77-92, ISSN: 1824-4785
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- Citations: 21
Raithatha A, Papadopoulou I, Stewart V, et al., 2016, Cervical Cancer Staging: A Resident's Primer: Women's Imaging., Radiographics, Vol: 36, Pages: 933-934
Papadopoulou I, Stewart V, Barwick TD, et al., 2016, Post-Radiation Therapy Imaging Appearances in Cervical Carcinoma, RADIOGRAPHICS, Vol: 36, Pages: 538-553, ISSN: 0271-5333
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- Citations: 23
Grech-Sollars M, Vaqas B, Thompson G, et al., 2015, NIMG-30an MRS and PET guided biopsy tool for ultrasound-based intra-operative neuro-navigational systems, Neuro-Oncology, Vol: 17, Pages: v160.2-v160, ISSN: 1522-8517
Ordidge K, Grech-Sollars M, Honeyfield L, et al., 2015, 18F-FLUOROMETHYLCHOLINE (18F-FMC) PET/CT AND MAGNETIC RESONANCE SPECTROSCOPY (MRS) IMAGING AND TISSUE BIOMARKERS OF CELL MEMBRANE TURNOVER IN PRIMARY BRAIN GLIOMAS-A PILOT STUDY, Meeting of the British-Neuro-Oncology-Society (BNOS), Publisher: OXFORD UNIV PRESS INC, Pages: 5-5, ISSN: 1522-8517
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- Citations: 1
Bosaily AE-S, Parker C, Brown LC, et al., 2015, PROMIS - Prostate MR imaging study: A paired validating cohort study evaluating the role of multi-parametric MRI in men with clinical suspicion of prostate cancer, CONTEMPORARY CLINICAL TRIALS, Vol: 42, Pages: 26-40, ISSN: 1551-7144
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- Citations: 69
Challapalli A, Barwick T, Pearson RA, et al., 2015, 3′-Deoxy-3′-<SUP>18</SUP>F-fluorothymidine positron emission tomography as an early predictor of disease progression in patients with advanced and metastatic pancreatic cancer, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 42, Pages: 831-840, ISSN: 1619-7070
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- Citations: 17
Johnston AC, Naresh K, Barwick T, et al., 2015, Cutaneous presentation of an aggressive plasmablastic neoplasm indiscriminate between lymphoma and myeloma, ANNALS OF HEMATOLOGY, Vol: 94, Pages: 691-692, ISSN: 0939-5555
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- Citations: 3
Barwick TD, Lyons OTA, Mikhaeel NG, et al., 2014, 18F-FDG PET-CT uptake is a feature of both normal diameter and aneurysmal aortic wall and is not related to aneurysm size, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 41, Pages: 2310-2318, ISSN: 1619-7070
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- Citations: 36
Naresh KN, Barwick T, Karadimitris A, 2014, IgG4 positive mucosa associated lymphoid tissue lymphoma of the orbit - lesson of the month, HISTOPATHOLOGY, Vol: 65, Pages: 718-721, ISSN: 0309-0167
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- Citations: 9
Tam HH, Arshad M, Bharwani N, et al., 2014, Textural features of primary cervical tumors on FDG PET/CT as a predictor of progression free survival, Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), Publisher: SPRINGER, Pages: S202-S202, ISSN: 1619-7070
Jackson JE, Barwick TD, 2014, Localization of pancreatic and gastrointestinal NETs, Tips and Tricks in Endocrine Surgery, Pages: 63-75, ISBN: 9780857299826
The imaging of gastroenteropancreatic (GEP) neuroendocrine tumors is best discussed by dividing them into two groups.
Challapalli A, Barwick T, Tomasi G, et al., 2014, Exploring the potential of [<SUP>11</SUP>C]choline-PET/CT as a novel imaging biomarker for predicting early treatment response in prostate cancer, NUCLEAR MEDICINE COMMUNICATIONS, Vol: 35, Pages: 20-29, ISSN: 0143-3636
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- Citations: 19
Barwick TD, Taylor A, Rockall A, 2013, Functional Imaging to Predict Tumor Response in Locally Advanced Cervical Cancer, CURRENT ONCOLOGY REPORTS, Vol: 15, Pages: 549-558, ISSN: 1523-3790
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- Citations: 36
Eccles A, Challapalli A, Khan S, et al., 2013, Thyroid Lymphoma Incidentally Detected by <SUP>18</SUP>F-Fluorocholine (FCH) PET/CT, CLINICAL NUCLEAR MEDICINE, Vol: 38, Pages: 755-757, ISSN: 0363-9762
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- Citations: 9
Eccles A, Challapalli A, Khan S, et al., 2013, Thyroid lymphoma incidentally detected by 18F-fluorocholine (FCH) PET/CT., Clinical nuclear medicine, Vol: 38, Pages: 755-757
A 63-year-old man underwent a (18)F-fluorocholine ((18)F-FCH) PET/CT for staging assessment of a high-risk locally advanced prostate cancer with an equivocal node on conventional workup (Gleason 4 + 5, PSA 11.1; T3b, N(0/1), M(0) on standard staging investigations). (18)F-FCH-avid disease was demonstrated in the prostate and several non-enlarged pelvic nodes. An incidental focus of tracer uptake was reported within the left lobe of the thyroid gland, with subtle enlargement of the left thyroid lobe on the CT component of the study. A diagnosis of diffuse large B-cell lymphoma was confirmed following thyroid ultrasound and cytology.
Challapalli A, Barwick T, Tomasi G, et al., 2012, Establishing the Use of [<SUP>11</SUP>C]Choline PET-CT as an Image-based Biomarker in Prostate Cancer: Evaluation of [<SUP>11</SUP> C]Choline Parameters Following Neoadjuvant Androgen Deprivation and Radical Radiation Therapy, 54th Annual Meeting of the American-Society-for-Radiation-Oncology (ASTRO), Publisher: ELSEVIER SCIENCE INC, Pages: S184-S184, ISSN: 0360-3016
Barwick T, Gnanasegaran G, Fogelman I, 2012, Potential applications and limitations of SPECT-CT in classifying bone lesions in patients with cancer, Radionuclide and Hybrid Bone Imaging, Pages: 735-749, ISBN: 9783642023996
The accurate assessment of bone involvement in cancer patients is highly important for optimum staging, management and response to treatment. Bone scintigraphy with 99mtechnechium-labelled methylene diphosphonate (99mTc-MDP) has for decades been the standard imaging modality in this setting due to its high sensitivity, availability, ability to image the entire skeleton and cost-effectiveness. However, it is non-specific and to overcome this further correlative imaging with plain radiographs or MRI may be required to establish the nature of an abnormality or abnormalities on bone scintigraphy. The recent introduction of SPECT/CT systems, which combine functional and anatomical/structural data acquired in the same session, provides opportunities for new imaging paradigms. This chapter shall discuss the potential applications and limitations of SPECT/CT in the assessment of the skeletal system in cancer patients.
Kauppila E, Allen R, Ifigeneia K, et al., 2012, Short-term Haematological and Biochemical Safety of Lu-177 DOTATATE Therapy, 25th Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), Publisher: SPRINGER, Pages: S587-S587, ISSN: 1619-7070
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