Publications
109 results found
Zerizer I, Al-Nahhas A, Towey D, et al., 2012, The role of early <SUP>18</SUP>F-FDG PET/CT in prediction of progression-free survival after <SUP>90</SUP>Y radioembolization: comparison with RECIST and tumour density criteria, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 39, Pages: 1391-1399, ISSN: 1619-7070
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- Citations: 72
El-Najjar I, Barwick T, Avril N, et al., 2012, The role of FDG-PET and bone marrow examination in lymphoma staging, ANNALS OF ONCOLOGY, Vol: 23, Pages: 89-91, ISSN: 0923-7534
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- Citations: 3
Barwick TD, Dhawan RT, Lewington V, 2012, Role of SPECT/CT in differentiated thyroid cancer, NUCLEAR MEDICINE COMMUNICATIONS, Vol: 33, Pages: 787-798, ISSN: 0143-3636
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- Citations: 18
Barwick TD, Zerizer I, Al-Nahhas A, 2012, Value of PET scanning, CLINICAL DILEMMAS IN PRIMARY LIVER CANCER, Editors: Williams, TaylorRobinson, Publisher: BLACKWELL SCIENCE PUBL, Pages: 118-123, ISBN: 978-0-470-65797-3
Gulliver N, Petro I, Barwick T, et al., 2011, Optimisation of the bed position acquisition time for <SUP>18</SUP>F-FDG PET/CT to ensure image quality and lesion detectability, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 38, Pages: S97-S97, ISSN: 1619-7070
Contractor KB, Challapalli A, Barwick T, et al., 2011, Use of [11C]choline PET-CT as a non invasive method for detecting pelvic lymph node status from prostate cancer and relationship with choline kinase expression, ISSN: 1078-0432
PURPOSE: To evaluate the accuracy and biological basis for [11C] choline-PET-CT in the nodal staging of high risk localised prostate cancer patients.EXPERIMENTAL DESIGN: Twenty eight patients underwent dynamic [11C] choline-PET-CT of the pelvis and lower abdomen prior to extended laparoscopic pelvic lymph node dissection (eLPL). The sensitivity and specificity of [11C]choline PET, [11C]choline PET-CT and MRI for nodal detection were calculated. Average and maximal standardized Uptake Values (SUVave, SUVmax) were compared with choline kinase alpha (CHKalpha) and Ki67 immunohistochemistry scores.RESULTS: 406 lymph nodes, in 26 patients, were assessable. 27 (6.7%) involved pelvic nodes at eLPL were detected in 9 patients. 17 out of the 27 involved nodes were sub-centimetre. The sensitivity and specificity on a per nodal basis were 18.5 % and 98.7%, 40.7% and 98.4 %, and 51.9% and 98.4% for MRI, [11C]choline PET and [11C]choline PET-CT, respectively. Sensitivity was higher for [11C]choline PET-CT compared with MRI (p=0.007). A higher nodal detection rate, including sub-centimetre nodes, was seen with [11C]choline PET-CT than MRI. Malignant lesions showed CHKalpha expression in both cytoplasm and nucleus. SUVave and SUVmax strongly correlated with CHKalpha staining intensity (r=0.68, p<0.0001 and r=0.63, p=0.0004, respectively). In contrast, Ki67 expression was generally low in all tumors. CONCLUSIONS: This study establishes the relationship between [11C]choline PET- CT uptake with choline kinase expression in prostate cancer and allows it to be used as a non-invasive means of staging pelvic lymph nodes, being highly specific and more sensitive than MRI including the detection of sub-centimetre disease.
Zerizer I, Barwick T, Tait P, et al., 2010, The role of <SUP>18</SUP>FDG-PET/CT and contrast enhanced CT in response assessment post intra-arterial <SUP>90</SUP>Yttrium SIR-Spheres therapy: comparison between SUV and Hounsefield unit, 23rd Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), Publisher: SPRINGER, Pages: S279-S279, ISSN: 1619-7070
Salem S, Patel NH, Barwick T, et al., 2010, Occult Squamous Cell Carcinoma of the Uvula Detected by F-18 FDG PET/CT in a Case of Carcinoma of Unknown Primary in the Head and Neck, CLINICAL NUCLEAR MEDICINE, Vol: 35, Pages: 800-801, ISSN: 0363-9762
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- Citations: 6
Barwick T, Murray I, Megadmi H, et al., 2010, Single photon emission computed tomography (SPECT)/computed tomography using Iodine-123 in patients with differentiated thyroid cancer: additional value over whole body planar imaging and SPECT., Eur J Endocrinol, Vol: 162, Pages: 1131-1139
OBJECTIVE: The aim of the study was to assess the diagnostic performance of co-registered single photon emission computed tomography (SPECT)/computed tomography (CT) compared to Iodine-123 whole body gamma camera (WBGC) imaging and to SPECT alone in patients with differentiated thyroid cancer. METHODS: WBGC and SPECT/CT (n=85) imaging of the neck and thorax was performed in 79 consecutive patients. Three experienced observers reviewed: i) WBGC images followed by ii) SPECT alone, and iii) co-registered SPECT/CT. Foci of increased radioiodine uptake were classified on a five-point scale. Biopsy, other imaging modalities, and clinical follow-up served as the reference standard. RESULTS: Twenty-two patients had local recurrence or metastatic thyroid cancer (11 were radioiodine negative), 9 had remnant thyroid tissue, and 54 had no evidence of disease. When classifying equivocal, probably, and definitely malignant findings as positive for malignancy, the sensitivity, specificity, positive predictive value, and negative predictive value were as follows: 41, 68, 31, and 77% for WBGC imaging; 45, 89, 59, and 82% for WBGC plus SPECT imaging; and 50, 100, 100, and 85% for WBGC plus SPECT/CT imaging respectively. The specificity was improved by the addition of SPECT (P=0.0002) and SPECT/CT (P<0.0001) than to WBGC imaging. SPECT/CT was also more specific than WBGC plus SPECT imaging (P=0.016). In a study-based analysis, SPECT/CT provided additional diagnostic information in 42% (36/85) of cases. SPECT/CT provided further characterization in 70% (63/90) of foci and improved the diagnostic confidence of all three observers. CONCLUSION: The addition of SPECT/CT significantly improved the diagnostic information over Iodine-123 WBGC imaging and WBGC plus SPECT imaging alone.
Zerizer I, Tan K, Khan S, et al., 2010, Role of FDG-PET and PET/CT in the diagnosis and management of vasculitis, EUROPEAN JOURNAL OF RADIOLOGY, Vol: 73, Pages: 504-509, ISSN: 0720-048X
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- Citations: 88
Zerizer I, Tan K, Khan S, et al., 2010, Role of FDG-PET and PET/CT in the diagnosis and management of vasculitis., Eur J Radiol, Vol: 73, Pages: 504-509
PURPOSE: to investigate the role of FDG-PET and PET/CT in the evaluation of vasculitis. MATERIALS AND METHODS: a systematic revision of the papers published in PubMed/Medline until December 2009 was done. RESULTS: FDG-PET and PET/CT have been proven to be valuable in the diagnosis of large-vessel vasculitis, especially giant cells arteritis with sensitivity values ranging 77% to 92%, and specificity values ranging 89% to 100%. In particular, FDG-PET/CT has demonstrated the potential to non-invasively diagnose the onset of the vasculitis earlier than traditional anatomical imaging techniques, thus enabling prompt treatment. False positive results mainly occur in the differential diagnosis between vasculitis and atherosclerotic vessels in elderly patients. Another area where FDG-PET/CT is gaining wider acceptance is in monitoring response to therapy; it can reliably detect the earliest changes of disease improvement post-therapy, and persistent activity is an indicator of non-responders to therapy. A few data have been reported about medium/small vessel vasculitis. DISCUSSION: FDG-PET and PET/CT have proven utility: (a) in the initial diagnosis of patients suspected of having vasculitis particularly in those who present with non-specific symptoms; (b) in the identification of areas of increased FDG uptake in which a biopsy should be done for obtaining a diagnosis; (c) in evaluating the extent of the disease; (d) in assessing response to treatment.
Barwick T, Bencherif B, Mountz JM, et al., 2009, Molecular PET and PET/CT imaging of tumour cell proliferation using F-18 fluoro-L-thymidine: a comprehensive evaluation, NUCLEAR MEDICINE COMMUNICATIONS, Vol: 30, Pages: 908-917, ISSN: 0143-3636
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- Citations: 77
Gnanasegaran G, Barwick T, Adamson K, et al., 2009, Multislice SPECT/CT in Benign and Malignant Bone Disease: When the Ordinary Turns Into the Extraordinary, SEMINARS IN NUCLEAR MEDICINE, Vol: 39, Pages: 431-442, ISSN: 0001-2998
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- Citations: 42
Barwick TD, Hodson A, Dunn J, et al., 2009, Evaluation of optimum timing and method of response assessment with F-18 FDG PET during salvage chemotherapy prior to autologous stem cell transplant in relapsed/refractory aggressive Non Hodgkin's Lymphoma and Hodgkin's Lymphoma, Publisher: SPRINGER, Pages: S350-S350, ISSN: 1619-7070
Khan M, Al-Nahhas A, Khan S, et al., 2009, Oncological imaging with Ga-68 PET: The story so far, Publisher: SOC NUCLEAR MEDICINE INC, ISSN: 0161-5505
Grossman AB, Kelly P, Rockall A, et al., 2007, Cushing's syndrome caused by an occult source: difficulties in diagnosis and management (vol 2, pg 642, 2006), NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM, Vol: 3, Pages: 69-69, ISSN: 1745-8366
Sahdev A, Hughes JH, Barwick T, et al., 2007, Computed tomography features of recurrent ovarian carcinoma according to time to relapse, ACTA RADIOLOGICA, Vol: 48, Pages: 1038-1045, ISSN: 0284-1851
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- Citations: 15
Grossman AB, Kelly P, Rockall A, et al., 2006, Cushing's syndrome caused by an occult source: difficulties in diagnosis and management, NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM, Vol: 2, Pages: 642-647, ISSN: 1745-8366
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- Citations: 24
Barwick TD, Rockall AG, Barton DP, et al., 2006, Imaging of endometrial adenocarcinoma, CLINICAL RADIOLOGY, Vol: 61, Pages: 545-555, ISSN: 0009-9260
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- Citations: 68
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