11 results found
Brune KD, Bayer TS, 2012, Engineering microbial consortia to enhance biomining and bioremediation, FRONTIERS IN MICROBIOLOGY, Vol: 3, ISSN: 1664-302X
Davidson EA, Windram OPF, Bayer TS, 2012, Building Synthetic Systems to Learn Nature's Design Principles, EVOLUTIONARY SYSTEMS BIOLOGY, Vol: 751, Pages: 411-429, ISSN: 0065-2598
Voigt CA, Bayer TS, 2011, Biological systems for the production of commercially valuable compounds, US 2011/0165618A1
Bayer TS, 2010, Transforming biosynthesis into an information science, NATURE CHEMICAL BIOLOGY, Vol: 6, Pages: 859-861, ISSN: 1552-4450
Bayer TS, 2010, Using Synthetic Biology to Understand the Evolution of Gene Expression, CURRENT BIOLOGY, Vol: 20, Pages: R772-R779, ISSN: 0960-9822
Bayer TS, Widmaier DM, Temme K, et al., 2009, Synthesis of Methyl Halides from Biomass Using Engineered Microbes, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 131, Pages: 6508-6515, ISSN: 0002-7863
Bayer TS, Hoff KG, Beisel CL, et al., 2009, Synthetic control of a fitness tradeoff in yeast nitrogen metabolism., J Biol Eng, Vol: 3
BACKGROUND: Microbial communities are involved in many processes relevant to industrial and medical biotechnology, such as the formation of biofilms, lignocellulosic degradation, and hydrogen production. The manipulation of synthetic and natural microbial communities and their underlying ecological parameters, such as fitness, evolvability, and variation, is an increasingly important area of research for synthetic biology. RESULTS: Here, we explored how synthetic control of an endogenous circuit can be used to regulate a tradeoff between fitness in resource abundant and resource limited environments in a population of Saccharomyces cerevisiae. We found that noise in the expression of a key enzyme in ammonia assimilation, Gdh1p, mediated a tradeoff between growth in low nitrogen environments and stress resistance in high ammonia environments. We implemented synthetic control of an endogenous Gdh1p regulatory network to construct an engineered strain in which the fitness of the population was tunable in response to an exogenously-added small molecule across a range of ammonia environments. CONCLUSION: The ability to tune fitness and biological tradeoffs will be important components of future efforts to engineer microbial communities.
Beisel CL, Bayer TS, Hoff KG, et al., 2008, Model-guided design of ligand-regulated RNAi for programmable control of gene expression, MOLECULAR SYSTEMS BIOLOGY, Vol: 4, ISSN: 1744-4292
Bayer TS, Booth LN, Knudsen SM, et al., 2005, Arginine-rich motifs present multiple interfaces for specific binding by RNA, RNA, Vol: 11, Pages: 1848-1857, ISSN: 1355-8382
Bayer TS, Smolke CD, 2005, Programmable ligand-controlled riboregulators of eukaryotic gene expression, NATURE BIOTECHNOLOGY, Vol: 23, Pages: 337-343, ISSN: 1087-0156
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