Imperial College London

Professor Tom Bourne

Faculty of MedicineDepartment of Surgery & Cancer

Professor of Practice (Gynaecology)
 
 
 
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Contact

 

+44 (0)20 3313 5131t.bourne Website

 
 
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Location

 

Early pregnancy and acute gynaecologyInstitute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Publication Type
Year
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416 results found

Craciunas L, Gallos I, Chu J, Bourne T, Quenby S, Brosens JJ, Coomarasamy Aet al., 2019, Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis., Hum Reprod Update

BACKGROUND: Early reproductive failure is the most common complication of pregnancy with only 30% of conceptions reaching live birth. Establishing a successful pregnancy depends upon implantation, a complex process involving interactions between the endometrium and the blastocyst. It is estimated that embryos account for one-third of implantation failures, while suboptimal endometrial receptivity and altered embryo-endometrial dialogue are responsible for the remaining two-thirds. Endometrial receptivity has been the focus of extensive research for over 80 years, leading to an indepth understanding of the processes associated with embryo-endometrial cross-talk and implantation. However, little progress has been achieved to translate this understanding into clinically meaningful prognostic tests and treatments for suboptimal endometrial receptivity. OBJECTIVE AND RATIONALE: The objective of this systematic review was to examine the evidence from observational studies supporting the use of endometrial receptivity markers as prognostic factors for pregnancy outcome in women wishing to conceive, in order to aid clinicians in choosing the most useful marker in clinical practice and for informing further research. SEARCH METHODS: The review protocol was registered with PROSPERO (CRD42017077891). MEDLINE and Embase were searched for observational studies published from inception until 26 February 2018. We included studies that measured potential markers of endometrial receptivity prior to pregnancy attempts and reported the subsequent pregnancy outcomes. We performed association and accuracy analyses using clinical pregnancy as an outcome to reflect the presence of receptive endometrium. The Newcastle-Ottawa scale for observational studies was employed to assess the quality of the included studies. OUTCOMES: We included 163 studies (88 834 women) of moderate overall quality in the narrative synthesis, out of which 96 were included in the meta-analyses. Studies reported on

JOURNAL ARTICLE

Jordans IPM, de Leeuw RA, Stegwee SI, Amso NN, Barri-Soldevila PN, van den Bosch T, Bourne T, Brolmann HAM, Donnez O, Dueholm M, Hehenkamp WJK, Jastrow N, Jurkovic D, Mashiach R, Naji O, Streuli I, Timmerman D, van der Voet LF, Huirne JAFet al., 2019, Sonographic examination of uterine niche in non-pregnant women: a modified Delphi procedure, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 53, Pages: 107-+, ISSN: 0960-7692

JOURNAL ARTICLE

Bobdiwala S, Saso S, Verbakel JY, Al-Memar M, Van Calster B, Timmerman D, Bourne Tet al., 2019, Diagnostic protocols for the management of pregnancy of unknown location: a systematic review and meta-analysis, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 126, Pages: 190-198, ISSN: 1470-0328

JOURNAL ARTICLE

Brown RG, Al-Memar M, Marchesi JR, Lee YS, Smith A, Chan D, Lewis H, Kindinger L, Terzidou V, Bourne T, Bennett PR, MacIntyre DAet al., 2018, Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabor rupture of the fetal membranes., Transl Res

Vaginal bacterial community composition influences pregnancy outcome. Preterm prelabor rupture of the fetal membranes (PPROM), which precedes 30% of all spontaneous preterm births, is associated with high vaginal bacterial diversity prior to rupture. The point at which vaginal bacterial diversity is established before PPROM is unknown. In this study, we use metataxonomics to longitudinally characterize the vaginal bacterial composition from as early as 6 weeks of gestation in women at high (n = 38) and low (n = 22) risk of preterm birth who subsequently experience PPROM and in women delivering at term without complications (n = 36). Reduced Lactobacillus spp. abundance and high diversity was observed prior to PPROM in 20% and 26% of women at low and high risk of preterm births respectively, but in only 3% of women who delivered at term. PPROM was associated with instability of bacterial community structure during pregnancy and a shift toward higher diversity predominately occurring during the second trimester. This was characterized by increased relative abundance of potentially pathogenic species including Prevotella, Peptoniphilus, Streptococcus, and Dialister. This study identifies reduced Lactobacillus spp. abundance and increasing vaginal bacterial diversity as an early risk factor for PPROM and highlights the need for interventional studies designed to assess the impact of modifying vaginal bacterial composition for the prevention of preterm birth.

JOURNAL ARTICLE

Harb HM, Knight M, Bottomley C, Overton C, Tobias A, Gallos ID, Shehmar M, Farquharson R, Horne A, Latthe P, Edi-Osagie E, MacLean M, Marston E, Zamora J, Dawood F, Small R, Ross J, Bourne T, Coomarasamy A, Jurkovic Det al., 2018, Caesarean scar pregnancy in the UK: a national cohort study, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 125, Pages: 1663-1670, ISSN: 1470-0328

JOURNAL ARTICLE

May J, Duncan C, Mol B, Bhattacharya S, Daniels J, Middleton L, Hewitt C, Coomarasamy A, Jurkovic D, Bourne T, Bottomley C, Peace-Gadsby A, Doust A, Tong S, Horne AWet al., 2018, A multi-centre, double-blind, placebo-controlled, randomised trial of combination methotrexate and gefitinib versus methotrexate alone to treat tubal ectopic pregnancies (GEM3): trial protocol, TRIALS, Vol: 19, ISSN: 1745-6215

JOURNAL ARTICLE

Farren J, Mitchell-Jones N, Verbakel JY, Timmerman D, Jalmbrant M, Bourne Tet al., 2018, The psychological impact of early pregnancy loss, HUMAN REPRODUCTION UPDATE, Vol: 24, Pages: 731-749, ISSN: 1355-4786

JOURNAL ARTICLE

Epstein E, Fischerova D, Valentin L, Testa AC, Franchi D, Sladkevicius P, Fruhauf F, Lindqvist PG, Mascilini F, Fruscio R, Haak LA, Opolskiene G, Pascual MA, Alcazar JL, Chiappa V, Guerriero S, Carlson JW, Van Holsbeke C, Leone FPG, De Moor B, Bourne T, van Calster B, Installe A, Timmerman D, Verbakel JY, Van den Bosch Tet al., 2018, Ultrasound characteristics of endometrial cancer as defined by International Endometrial Tumor Analysis (IETA) consensus nomenclature: prospective multicenter study (vol 51, pg 818, 2018), ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 52, Pages: 684-684, ISSN: 0960-7692

JOURNAL ARTICLE

Andreotti RF, Timmerman D, Benacerraf BR, Bennett GL, Bourne T, Brown DL, Coleman BG, Frates MC, Froyman W, Goldstein SR, Hamper UM, Horrow MM, Hernanz-Schulman M, Reinhold C, Strachowski LM, Glanc Pet al., 2018, Ovarian-Adnexal Reporting Lexicon for Ultrasound: A White Paper of the ACR Ovarian-Adnexal Reporting and Data System Committee, JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY, Vol: 15, Pages: 1415-1429, ISSN: 1546-1440

JOURNAL ARTICLE

Dall'Asta A, Shah H, Masini G, Paramasivam G, Yazbek J, Bourne T, Lees CCet al., 2018, Evaluation of tramline sign for prenatal diagnosis of abnormally invasive placenta using three-dimensional ultrasound and Crystal Vue rendering technology, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 52, Pages: 403-404, ISSN: 0960-7692

JOURNAL ARTICLE

Saso S, Tziraki M, Clancy NT, Song L, Bracewell-Milnes T, Jones BP, Al-Memar M, Yazbek J, Thum M-Y, Sayasneh A, Bourne T, Smith JR, Elson DS, Ghaem-Maghami Set al., 2018, Use of Laser Speckle Contrast Analysis during pelvic surgery in a uterine transplantation model, FUTURE SCIENCE OA, Vol: 4, ISSN: 2056-5623

JOURNAL ARTICLE

Landolfo C, Valentin L, Franchi D, Van Holsbeke C, Fruscio R, Froyman W, Sladkevicius P, Kaijser J, Ameye L, Bourne T, Savelli L, Coosemans A, Testa A, Timmerman Det al., 2018, Differences in ultrasound features of papillations in unilocular-solid adnexal cysts: a retrospective international multicenter study, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 52, Pages: 269-278, ISSN: 0960-7692

JOURNAL ARTICLE

Epstein E, Fischerova D, Valentin L, Testa AC, Franchi D, Sladkevicius P, Fruehauf F, Lindqvist PG, Mascilini F, Fruscio R, Haak LA, Opolskiene G, Pascual MA, Alcazar JL, Chiappa V, Guerriero S, Carlson JW, Van Holsbeke C, Leone FPG, De Moor B, Bourne T, van Calster B, Installe A, Timmerman D, Verbakel JY, Van den Bosch Tet al., 2018, Ultrasound characteristics of endometrial cancer as defined by International Endometrial Tumor Analysis (IETA) consensus nomenclature: prospective multicenter study, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 51, Pages: 818-828, ISSN: 0960-7692

JOURNAL ARTICLE

Van den Bosch T, de Bruijn AM, de Leeuw RA, Dueholm M, Exacoustos C, Valentin L, Bourne T, Timmerman D, Huirne JAFet al., 2018, A sonographic classification and reporting system for diagnosing adenomyosis., Ultrasound Obstet Gynecol

OBJECTIVE: To develop a uniform classification and standardized reporting system of ultrasound findings of adenomyosis using the Morphological Uterus Sonographic Assessment (MUSA) criteria. METHOD: The opinion presented in this manuscript was built based on a thorough discussion among all authors, including a Delphi procedure. Selected images and videos of typical cases of the different morphological variations of adenomyosis were used in the debates. RESULTS: A classification and reporting system of different types of adenomyosis based on ultrasound was agreed upon including (1) identification of adenomyosis based on MUSA criteria, (2) disease location (anterior, posterior, left lateral, right lateral, fundal), (3) classification of the lesions as focal or diffuse, (4) presence or absence of intralesional cysts, (5) myometrial layer involvement (junctional zone, myometrium, serosal involvement), (6) disease extent (< 25%, 25-50%, > 50% of uterine volume affected by adenomyosis) and (7) lesion size. CONCLUSIONS: We proposes a uniform classification and reporting system of different types of adenomyosis based on ultrasound. The clinical relevance of this approach needs to be evaluated in further studies. This article is protected by copyright. All rights reserved.

JOURNAL ARTICLE

Saso S, Clancy NT, Jones BP, Bracewell-Milnes T, Al-Memar M, Cannon EM, Ahluwalia S, Yazbek J, Thum M-Y, Bourne T, Elson DS, Smith JR, Ghaem-Maghami Set al., 2018, Use of biomedical photonics in gynecological surgery: a uterine transplantation model, FUTURE SCIENCE OA, Vol: 4, ISSN: 2056-5623

JOURNAL ARTICLE

, 2018, Dewhurst's Textbook of Obstetrics and Gynaecology, Publisher: Wiley Blackwell, ISBN: 978-1-119-21142-6

The definitive textbook on the subject

BOOK

Mitchell-Jones N, Farren JA, Tobias A, Bourne T, Bottomley Cet al., 2017, Ambulatory versus inpatient management of severe nausea and vomiting of pregnancy: a randomised control trial with patient preference arm, BMJ OPEN, Vol: 7, ISSN: 2044-6055

JOURNAL ARTICLE

Bourne T, 2017, We need to change the culture around complaints procedures., BMJ, Vol: 359, Pages: j5313-j5313, ISSN: 0959-8138

JOURNAL ARTICLE

Bourne T, De Cock B, Wynants L, Peters M, Van Audenhove C, Timmerman D, Van Calster B, Jalmbrant Met al., 2017, Doctors' perception of support and the processes involved in complaints investigations and how these relate to welfare and defensive practice: a cross-sectional survey of the UK physicians, BMJ OPEN, Vol: 7, ISSN: 2044-6055

JOURNAL ARTICLE

Epstein E, Fischerova D, Valentin L, Testa AC, Franchi D, Sladkevicius P, Filip F, Mascilini F, Fruscio R, Haak LA, Opolskiene G, Pascual MA, Alcazar JL, Chiappa V, Guerriero S, Bourne T, Installe A, Timmerman D, Verbakel JY, Van den Bosch Tet al., 2017, ULTRASOUND CHARACTERISTICS OF ENDOMETRIAL CANCER AS DEFINED BY THE INTERNATIONAL ENDOMETRIAL TUMOR ANALYSIS (IETA) CONSENSUS NOMENCLATURE-A PROSPECTIVE MULTICENTER STUDY, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 33-33, ISSN: 1048-891X

CONFERENCE PAPER

Wynants L, Timmerman D, Verbakel JY, Testa A, Savelli L, Fischerova D, Franchi D, Van Holsbeke C, Epstein E, Froyman W, Guerriero S, Rossi A, Fruscio R, Leone FPG, Bourne T, Valentin L, Van Calster Bet al., 2017, Clinical Utility of Risk Models to Refer Patients with Adnexal Masses to Specialized Oncology Care: Multicenter External Validation Using Decision Curve Analysis, CLINICAL CANCER RESEARCH, Vol: 23, Pages: 5082-5090, ISSN: 1078-0432

JOURNAL ARTICLE

Shah H, Al-Memar M, de Bakker B, Fourie H, Lees C, Bourne Tet al., 2017, The first-trimester fetal central nervous system: a novel ultrasonographic perspective, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, Vol: 217, Pages: 220-221, ISSN: 0002-9378

JOURNAL ARTICLE

Bobdiwala S, Al-Memar M, Farren J, Bourne Tet al., 2017, Factors to consider in pregnancy of unknown location, WOMENS HEALTH, Vol: 13, Pages: 27-33, ISSN: 1745-5057

JOURNAL ARTICLE

Grewal K, Al-Memar M, Fourie H, Djapardy V, Bourne Tet al., 2017, The natural history of pregnancy related enhanced myometrial vascularity, 33rd Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 360-361, ISSN: 0268-1161

CONFERENCE PAPER

Froyman W, Wynants L, Landolfo C, Bourne T, Valentin L, Testa A, Sladkevicius P, Franchi D, Fischerova D, Savelli L, Van Calster B, Timmerman Det al., 2017, Validation of the Performance of International Ovarian Tumor Analysis (IOTA) Methods in the Diagnosis of Early Stage Ovarian Cancer in a Non-Screening Population, DIAGNOSTICS, Vol: 7, ISSN: 2075-4418

JOURNAL ARTICLE

Glanc P, Benacerraf B, Bourne T, Brown D, Coleman BG, Crum C, Dodge J, Levine D, Pavlik E, Timmerman D, Ueland FR, Wolfman W, Goldstein SRet al., 2017, First International Consensus Report on Adnexal Masses: Management Recommendations, JOURNAL OF ULTRASOUND IN MEDICINE, Vol: 36, Pages: 849-863, ISSN: 0278-4297

JOURNAL ARTICLE

Al-Memar M, Bobdiwala S, Lee Y, Fourie H, Smith A, Marchesi J, Timmerman D, Bennett PR, Bourne T, MacIntyre DAet al., 2017, Association between vaginal microbiome dysbiosis and miscarriage, Publisher: WILEY, Pages: 65-65, ISSN: 1470-0328

CONFERENCE PAPER

Bobdiwala S, Farren J, Mitchell-Jones N, Ayim F, Abughazza O, Al-Memar M, Bottomley C, Gould D, Kothari A, Sur S, Stalder S, Timmerman D, Bourne Tet al., 2017, Assessing the value of endometrial thickness in triaging women with a pregnancy of unknown location, Publisher: WILEY, Pages: 8-8, ISSN: 1470-0328

CONFERENCE PAPER

Mitchell-Jones N, Farren J, Tobias A, Bobdiwala S, Bourne T, Bottomley Cet al., 2017, Efficacy of outpatient management of severe nausea and vomiting (hyperemesis gravidarum): a randomised controlled trial and patient preference trial, Publisher: WILEY, Pages: 7-7, ISSN: 1470-0328

CONFERENCE PAPER

Bobdiwala S, De Cock B, Abdallah Y, Al-Memar M, Harvey R, Fisher R, Stalder C, Timmerman D, Van Calster B, Bourne Tet al., 2017, The potential use of urinary beta-human chorionic gonadotrophin (beta-hCG) for managing pregnancies of unknown location: Correlating urinary and serum beta-hCG levels using two immunoassays, Publisher: WILEY, Pages: 8-8, ISSN: 1470-0328

CONFERENCE PAPER

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