Imperial College London
Alternate

Professor Tom Bourne

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Gynaecology
 
 
 
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Contact

 

+44 (0)20 3313 5131t.bourne Website

 
 
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Location

 

Early pregnancy and acute gynaecologyInstitute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

552 results found

Brännström M, Zackrisson U, Hagström HG, Josefsson B, Hellberg P, Granberg S, Collins WP, Bourne Tet al., 1998, Preovulatory changes of blood flow in different regions of the human follicle, Fertility and Sterility, Vol: 69, Pages: 435-442, ISSN: 0015-0282

Objective: To assess regional changes in ultrasound-derived indices of blood flow in the dominant human follicle after the plasma LH surge. Design: A cross-sectional, prospective study. Setting: Reproductive medicine unit at a university. Patient(s): Women attending an assisted conception clinic to determine the appropriate time to transfer previously frozen embryos during a natural cycle. Intervention(s): Transvaginal ultrasonography with color Doppler imaging and pulsed Doppler spectral analysis was used to obtain indices of blood flow and velocity from vessels in the base, lateral part, and apex of the dominant follicle on days 10-12 (from day 1 of menses) and after the LH surge, but before rupture. Immunoassays were used to measure the blood concentrations of LH twice daily (at 8-10 A.M. and 4-6 P.M.) from cycle day 10. Main Outcome Measure(s): The pulsatility index (PI), resistance index (RI), peak systolic velocity (PSV), and time-averaged maximum velocity (TAMXV) in the uterine arteries and three regions of the dominant follicle (apical, lateral, and basal parts); follicular volume; the day and time of the onset of the LH surge (defined as first concentration of LH >22 U/L) and the times of each scan. Result(s): Twenty-two women (aged 28-39 years) were studied and seven were scanned on days 10-12. A retrospective examination of the data from the remainder showed that eight were scanned <20 hours after onset of the LH surge and seven were scanned >20 hours after the onset of the LH surge. There was a significant increase in follicular volume after the LH surge. The PI was similar in vessels from the base (0.86 ± 0.11; mean ± SEM), lateral part (0.72 ± 0.51) and apex (0.67 ± 0.09) at cycle days 10-12 and then gradually decreased in the apex. There were similar changes in the RI. The PSV (mean ± SEM; cm/s) was similar in vessels from the base (10.1 ± 1.64), lateral side (8.2 ± 1.43), and apex (9.2 ±

Journal article

Collins WP, Bourne TH, Campbell S, 1998, Screening strategies for ovarian cancer, CURRENT OPINION IN OBSTETRICS & GYNECOLOGY, Vol: 10, Pages: 33-39, ISSN: 1040-872X

Journal article

Tailor A, Jurkovic D, Bourne TH, Collins WP, Campbell Set al., 1997, Sonographic prediction of malignancy in adnexal masses using multivariate logistic regression analysis, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 10, Pages: 41-47, ISSN: 0960-7692

Journal article

Bourne T, Hamberger L, Hahlin M, Granberg Set al., 1997, Ultrasound in gynecology: Endometrium, INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, Vol: 56, Pages: 115-127, ISSN: 0020-7292

Journal article

Istre O, Forman A, Bourne TH, 1996, The relationship between preoperative endometrial thickness, the anteroposterior diameter of the uterus and clinical outcome following transcervical resection of the endometrium, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 8, Pages: 412-416, ISSN: 0960-7692

Journal article

Istre O, HolmNielsen P, Bourne T, Forman Aet al., 1996, Hormone replacement therapy after transcervical resection of the endometrium, OBSTETRICS AND GYNECOLOGY, Vol: 88, Pages: 767-770, ISSN: 0029-7844

Journal article

Nargund G, Doyle PE, Bourne TH, Parsons JH, Cheng WC, Campbell S, Collins WPet al., 1996, Ultrasound derived indices of follicular blood flow before HCG administration and the prediction of oocyte recovery and preimplantation embryo quality, HUMAN REPRODUCTION, Vol: 11, Pages: 2512-2517, ISSN: 0268-1161

Journal article

Bourne TH, Hagstrom HG, Hahlin M, Josefsson B, Granberg S, Hellberg P, Hamberger L, Collins WPet al., 1996, Ultrasound studies of vascular and morphological changes in the human corpus luteum during the menstrual cycle, FERTILITY AND STERILITY, Vol: 65, Pages: 753-758, ISSN: 0015-0282

Journal article

Athanasiou S, Bourne TH, Khalid A, Okokon EV, Crayford TJB, Hagstrom HG, Campbell S, Collins WPet al., 1996, Effects of indomethacin on follicular structure, vascularity, and function over the periovulatory period in women, FERTILITY AND STERILITY, Vol: 65, Pages: 556-560, ISSN: 0015-0282

Journal article

Bourne TH, Hagstrom HG, Granberg S, Josefsson B, Hahlin M, Hellberg P, Hamberger L, Collins WPet al., 1996, Ultrasound studies of vascular and morphological changes in the human uterus after a positive self-test for the urinary luteinizing hormone surge, HUMAN REPRODUCTION, Vol: 11, Pages: 369-375, ISSN: 0268-1161

Journal article

Nargund G, Bourne T, Doyle P, Parsons J, Cheng W, Campbell S, Collins Wet al., 1996, Associations between ultrasound indices of follicular blood flow, oocyte recovery and preimplantation embryo quality, HUMAN REPRODUCTION, Vol: 11, Pages: 109-113, ISSN: 0268-1161

Journal article

Hagstrom HG, Hahlin M, BennegardEden B, Bourne T, Hamberger Let al., 1996, Regulation of corpus luteum function in early human pregnancy, FERTILITY AND STERILITY, Vol: 65, Pages: 81-86, ISSN: 0015-0282

Journal article

Tailor A, Jurkovic D, Bourne TH, Natucci M, Collins WP, Campbell Set al., 1996, A comparison of intratumoural indices of blood flow velocity and impedance for the diagnosis of ovarian cancer, ULTRASOUND IN MEDICINE AND BIOLOGY, Vol: 22, Pages: 837-843, ISSN: 0301-5629

Journal article

BOURNE TH, 1995, EVALUATING THE ENDOMETRIUM OF POSTMENOPAUSAL WOMEN WITH TRANSVAGINAL ULTRASONOGRAPHY, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 6, Pages: 75-80, ISSN: 0960-7692

Journal article

Kedar RP, Bourne TH, Powles TJ, Collins WP, Ashley SE, Cosgrove DO, Campbell Set al., 1995, Effects of tamoxifen on uterus and ovaries of postmenopausal women in a randomised breast cancer prevention trial, Obstetrical and Gynecological Survey, Vol: 50, Pages: 110-112, ISSN: 0029-7828

Journal article

Granberg S, Bourne TH, 1995, Transvaginal ultrasonography of endometrial disorders in postmenopausal women, Ultrasound Quarterly, Vol: 13, Pages: 61-74, ISSN: 0894-8771

Transvaginal ultrasonography has the potential to become integral to the management of endometrial pathology for women of all ages. In this review we outline the reproducibility of measuring endometrial thickness and examine the data that suggest that a single measurement of endometrial thickness may be used to avoid an invasive biopsy in many symptomatic postmenopausal women. An endometrial thickness of <5.0 mm is highly unlikely to contain significant pathology. The actions of hormone replacement therapy are described, and the effects of tamoxifen on the endometrium and their ultrasound characteristics are also outlined. A thick cystic endometrium in a woman taking tamoxifen has a 50% chance of being a polyp and is associated with hyperplasia and cancer. The use of color Doppler with reference to the detection of endometrial pathology and the impact of hydrosonography for the diagnosis of polyps is discussed. Finally, a number of simple clinical guidelines are suggested. © 1995 Lippincott-Raven Publishers, Philadelphia.

Journal article

Bourne TH, Jauniaux E, Jurkovic D, 1995, Transvaginal colour Doppler, Publisher: Springer

This practical comprehensive guide to the new technique of transvaginal colour Doppler gives an insight to its clinical use for all practitioners and ...

Book

CREIGHTON S, BOURNE TH, LAWTON FG, CRAYFORD TJB, VYAS S, CAMPBELL S, COLLINS WPet al., 1994, USE OF TRANSVAGINAL ULTRASONOGRAPHY WITH COLOR DOPPLER IMAGING TO DETERMINE AN APPROPRIATE TREATMENT REGIMEN FOR UTERINE FIBROIDS WITH A GNRH AGONIST BEFORE SURGERY - A PRELIMINARY-STUDY, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 4, Pages: 494-498, ISSN: 0960-7692

Journal article

MARSH MS, BOURNE TH, WHITEHEAD MI, COLLINS WP, CAMPBELL Set al., 1994, THE TEMPORAL EFFECT OF PROGESTOGEN ON UTERINE ARTERY PULSATILITY INDEX IN POSTMENOPAUSAL WOMEN RECEIVING SEQUENTIAL HORMONE REPLACEMENT THERAPY, FERTILITY AND STERILITY, Vol: 62, Pages: 771-774, ISSN: 0015-0282

Journal article

Parkes CA, Smith D, Wald NJ, Bourne THet al., 1994, Feasibility study of a randomised trial of ovarian cancer screening among the general population., J Med Screen, Vol: 1, Pages: 209-214, ISSN: 0969-1413

OBJECTIVE: To determine the feasibility of a randomised trial of ovarian cancer screening among women attending a breast cancer screening centre. DESIGN: Randomised controlled trial of ovarian cancer screening using transvaginal ultrasonography as a primary screening test and colour Doppler imaging as a secondary screening test in the screened group and no intervention in the control group. SETTING: Reading breast cancer screening centre (United Kingdom). SUBJECTS: 8678 women, without a bilateral oophorectomy or hysterectomy, aged between 50 and 64 attending for NHS breast cancer screening between September 1989 and February 1993. MAIN OUTCOME MEASURES: Uptake of ovarian cancer screening among eligible women and the screening false positive rate (considered as the referral rate to a gynaecologist for surgical intervention). RESULTS: 82% (7124/8678) of eligible women agreed to join the trial and were randomly allocated in equal numbers to each arm of the trial. 3280 women had an initial scan. The false positive rate after ultrasonography alone was 2.9% (86/2952), but this dropped to 0.5% after colour Doppler as a secondary screening test. One stage I primary ovarian cancer was detected at screening in a 58 year old women. CONCLUSIONS: A randomised trial of ovarian cancer screening using ultrasonography and colour Doppler imaging is feasible and acceptable among women attending a breast cancer screening centre. The results indicate that the expected odds of being affected given a positive result in the general population would be about 1:12. A full randomised trial of ovarian cancer screening with mortality as the end point is needed to assess whether screening reduces mortality from this disease. A multicentre European trial is currently in progress.

Journal article

BOURNE TH, 1994, SHOULD CLINICAL DECISIONS BE MADE ABOUT OVARIAN MASSES USING TRANSVAGINAL COLOR DOPPLER, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 4, Pages: 357-360, ISSN: 0960-7692

Journal article

BOURNE TH, COLLINS WP, CAMPBELL S, POWLES TJet al., 1994, EFFECTS OF TAMOXIFEN ON UTERUS - REPLY, LANCET, Vol: 344, Pages: 623-623, ISSN: 0140-6736

Journal article

ISMAIL SM, 1994, EFFECTS OF TAMOXIFEN ON UTERUS, LANCET, Vol: 344, Pages: 622-623, ISSN: 0140-6736

Journal article

REYNOLDS K, FARZANEH F, COLLINS WP, CAMPBELL S, BOURNE TH, LAWTON F, MOGHADDAM A, HARRIS AL, BICKNELL Ret al., 1994, ASSOCIATION OF OVARIAN MALIGNANCY WITH EXPRESSION OF PLATELET-DERIVED ENDOTHELIAL-CELL GROWTH-FACTOR, JOURNAL OF THE NATIONAL CANCER INSTITUTE, Vol: 86, Pages: 1234-1238, ISSN: 0027-8874

Journal article

GRANBERG S, BUNDSEN P, BOURNE TH, ALMEN M, GRENTHE M, LEANDERSSON R, TONNBERG Cet al., 1994, THE USE OF TRANSVAGINAL ULTRASONOGRAPHY COMPARED TO ROUTINE GYNECOLOGICAL EXAMINATION TO CHECK THE LOCATION OF AN INTRAUTERINE CONTRACEPTIVE DEVICE, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 4, Pages: 316-319, ISSN: 0960-7692

Journal article

KEDAR RP, BOURNE TH, POWLES TJ, COLLINS WP, ASHLEY SE, COSGROVE DO, CAMPBELL Set al., 1994, EFFECTS OF TAMOXIFEN ON UTERUS AND OVARIES OF POSTMENOPAUSAL WOMEN IN A RANDOMIZED BREAST-CANCER PREVENTION TRIAL, LANCET, Vol: 343, Pages: 1318-1321, ISSN: 0140-6736

Journal article

KHULLAR V, SALVATORE S, CARDOZO L, BOURNE TH, ABBOTT D, KELLEHER Cet al., 1994, A NOVEL TECHNIQUE FOR MEASURING BLADDER WALL THICKNESS IN WOMEN USING TRANSVAGINAL ULTRASOUND, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 4, Pages: 220-223, ISSN: 0960-7692

Journal article

CAMPBELL S, BOURNE TH, TAN SL, COLLINS WPet al., 1994, HYSTEROSALPINGO CONTRAST SONOGRAPHY (HYCOSY) AND ITS FUTURE-ROLE WITHIN THE INVESTIGATION OF INFERTILITY IN EUROPE, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 4, Pages: 245-253, ISSN: 0960-7692

Journal article

GRANBERG S, WIKLAND M, BOURNE TH, HAMBERGER Let al., 1994, TRANSVAGINAL ULTRASOUND-GUIDED OVARIAN ENDOSCOPY - A NOVEL-APPROACH TO THE ASSESSMENT OF OVARIAN-TUMORS, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 4, Pages: 130-134, ISSN: 0960-7692

Journal article

BOURNE TH, CAMPBELL S, REYNOLDS K, HAMPSON J, BHATT L, CRAYFORD TJB, WHITEHEAD MI, COLLINS WPet al., 1994, THE POTENTIAL ROLE OF SERUM CA-125 IN AN ULTRASOUND-BASED SCREENING-PROGRAM FOR FAMILIAL OVARIAN-CANCER, GYNECOLOGIC ONCOLOGY, Vol: 52, Pages: 379-385, ISSN: 0090-8258

Journal article

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