Imperial College London
Alternate

Professor Tom Bourne

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Gynaecology
 
 
 
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Contact

 

+44 (0)20 3313 5131t.bourne Website

 
 
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Location

 

Early pregnancy and acute gynaecologyInstitute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Farren:2018:humupd/dmy025,
author = {Farren, J and Mitchell-Jones, N and Verbakel, JY and Timmerman, D and Jalmbrant, M and Bourne, T},
doi = {humupd/dmy025},
journal = {Human Reproduction Update},
pages = {731--749},
title = {The psychological impact of early pregnancy loss},
url = {http://dx.doi.org/10.1093/humupd/dmy025},
volume = {24},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUNDEarly pregnancy loss (EPL) is a common event, with scope for long-term personal and societal impact. There are three decades worth of published evidence of profound psychological sequelae in a significant proportion of women. However, the wide variety of outcomes, screening instruments, assessment timings and geographical locations makes it challenging to form a coherent picture of the morbidity within the whole group and its subgroups.OBJECTIVE AND RATIONALEThis review aims to investigate three questions. (1) What is the evidence for depression, anxiety and post-traumatic stress disorder (PTSD) following a miscarriage or an ectopic pregnancy in women and/or their partners? (2) What is the intensity and duration of these conditions, and how do they compare to those without losses? (3) Which patients have been found to be at highest risk of psychopathology? Answers to these questions are salient not only in day-to-day clinical interactions with those experiencing EPL, whose psychological needs may not be prioritized, but should also form the basis for tailoring healthcare policy in terms of screening for and treating the associated psychological morbidity.SEARCH METHODSThe following databases were searched, from the start of each database up to July 2017: MEDLINE (Ovid interface, 1948 onwards), Embase classic + Embase (Ovid interface, 1947 onwards), and PsychINFO (Ovid interface, 1806 onwards). Search strategies were developed using medical subject headings (MeSH). The concepts of psychological morbidity (anxiety, depression or PTSD) and pregnancy loss (miscarriage or ectopic pregnancy) were first expanded with the Boolean operator ‘or’, then linked together using ‘and’.Included studies were of prospective cohort design, including women or men following EPL (with the majority to have experienced losses before 24 weeks gestation), and reporting standardized psychometric measures for anxiety, depression and post-traumatic stress disord
AU  - Farren,J
AU  - Mitchell-Jones,N
AU  - Verbakel,JY
AU  - Timmerman,D
AU  - Jalmbrant,M
AU  - Bourne,T
DO  - humupd/dmy025
EP  - 749
PY  - 2018///
SN  - 1355-4786
SP  - 731
TI  - The psychological impact of early pregnancy loss
T2  - Human Reproduction Update
UR  - http://dx.doi.org/10.1093/humupd/dmy025
UR  - https://academic.oup.com/humupd/article/24/6/731/5094891
UR  - http://hdl.handle.net/10044/1/62886
VL  - 24
ER  -
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