Imperial College London
Alternate

Professor Tom Bourne

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Gynaecology
 
 
 
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Contact

 

+44 (0)20 3313 5131t.bourne Website

 
 
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Location

 

Early pregnancy and acute gynaecologyInstitute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Farren:2022:10.1136/bmjopen-2021-054490,
author = {Farren, J and Jalmbrant, M and Falconieri, N and Mitchell-Jones, N and Bobdiwala, S and Al-Memar, M and Parker, N and Van, Calster B and Timmerman, D and Bourne, T},
doi = {10.1136/bmjopen-2021-054490},
journal = {BMJ Open},
title = {Prognostic factors for post-traumatic stress, anxiety and depression in women after early pregnancy loss: a multi-centre prospective cohort study},
url = {http://dx.doi.org/10.1136/bmjopen-2021-054490},
volume = {12},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives: To investigate prognostic factors for anxiety, depression and post-traumatic stress symptoms one month after early pregnancy loss (EPL).Design: A prospective cohort study. Consecutive women were recruited, and demographic and clinical data collected.  Surveys containing the hospital anxiety and depression scale (HADS) and posttraumatic stress diagnostic scale (PDS) were emailed one month after a loss. Univariable logistic regression was performed to link factors with caseness of anxiety, depression or post-traumatic stress (PTS) according to screening measures.Setting: Early pregnancy units of three central London hospitals.Participants: 737/1116 eligible women with an EPL were recruited. 492 responded to HADS and 487 to PDS.Primary and secondary outcome measures: Primary outcome is the area under the curve (AUC) to predict any psychological morbidity (defined as moderate/severe anxiety or depression, or meeting screening criteria for PTS) for each variable. Further outcomes are explained variation (R-squared) and p-value for any morbidity, and AUC, explained variation, and p-value for each morbidity separately. Results: Women who had a current or past diagnosis of a psychiatric condition were more likely to meet criteria for anxiety, depression or PTS (75% for current versus 55% for past versus 30% for no diagnosis; AUC 0.61; R-squared 8.4%; p<0.0001), as were those with previous pregnancy loss (48% versus 30%; AUC 0.59; R-squared 4.3%; p<0.0001). Most of the assessed factors did not demonstrate potential utility in predicting psychological distress, including gestational age, overnight admission, time taken for diagnosis, pre-existing children, and the diagnosis itself (miscarriage versus ectopic versus other) (AUCs≤0.54; R-squared≤0.9%). Conclusions: Women with a history of mental health problems, or those with previous losses, may be at higher risk of psychological illness one month after pregnancy loss. However, prognostic ability was po
AU  - Farren,J
AU  - Jalmbrant,M
AU  - Falconieri,N
AU  - Mitchell-Jones,N
AU  - Bobdiwala,S
AU  - Al-Memar,M
AU  - Parker,N
AU  - Van,Calster B
AU  - Timmerman,D
AU  - Bourne,T
DO  - 10.1136/bmjopen-2021-054490
PY  - 2022///
SN  - 2044-6055
TI  - Prognostic factors for post-traumatic stress, anxiety and depression in women after early pregnancy loss: a multi-centre prospective cohort study
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2021-054490
UR  - https://bmjopen.bmj.com/content/12/3/e054490
UR  - http://hdl.handle.net/10044/1/94958
VL  - 12
ER  -
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