Imperial College London

ProfessorThomasBrand

Faculty of MedicineNational Heart & Lung Institute

Chair in Developmental Dynamics
 
 
 
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Contact

 

+44 (0)20 7594 8744t.brand Website CV

 
 
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Assistant

 

Miss Cheryl Costello +44 (0)20 7594 3001

 
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Location

 

337ICTEM buildingHammersmith Campus

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Summary

 

Summary

Professor Brand was recruited as a Professor and Chair of Developmental Dynamics in October 2009 from the University of Würzburg, Germany, where he was a Professor of Molecular Developmental Biology and Head of a Working Group in Cardiac Developmental Biology since 2004. He was a Group Leader at the Institute of Biochemistry and Biotechnology (Professor Hans-Henning Arnold), University of Braunschweig, Germany, from 1994 to 2004. He did his postdoctoral training with Professor Michael D. Schneider at Baylor College of Medicine in Houston, U.S.A, from 1991 to 1994. For his Ph.D. he worked at the Max-Planck Institute for Physiological and Clinical Research in Bad Nauheim, Germany (Professor Wolfgang Schaper), from 1988 to 1990. He studied Biology at the University of Bielefeld, Germany, from 1980 to 1987.

Professor Brand's research focuses on cardiac development and ageing. He is interested in  the development of the proepicardium, an embryonic structure that develops into the epicardium and the coronary vasculature. He is interested in the signaling process involved in left-right asymmetry development of the heart. Finally he works on a novel class of membrane proteins, the Popeye proteins, which are involved in stress adaptation of cardiac pacemaker activity.

Professor Brand is a referee for numerous journals, including Cardiovascular Research, Circulation, Circulation Research, Cell and Tissue Research, Development, Developmental Biology, Developmental Dynamics, EMBO Journal, EMBO Reports, International Journal of Developmental Biology, Journal of Clinical Investigation, Journal of Human Genetics, Journal of Molecular and Cellular Cardiology,  Mechanisms of Development, Nature Genetics. Professor Brand acts as a referee for the Wellcome Trust, the Medical Research Council (MRC), the German Research Foundation (DFG), the German Israeli Foundation (GIF), the Human Frontier Science Program (HFSP). He is a member of the Working group on Developmental Anatomy and Pathology of the European Society of Cardiology

Selected Publications

Journals

 

 

Schindler RF; Scotton C; Zhang J; Passarelli C; Ortiz-Bonnin B; Simrick S; Schwerte T; Poon KL; Fang M; Rinné S; Froese A; Nikolaev VO; Grunert C; Müller T; Tasca G; Sarathchandra P; Drago F; Dallapiccola B; Rapezzi C; Arbustini E; Di Raimo FR; Neri M; Selvatici R; Gualandi F; Fattori F; Pietrangelo A; Li W; Jiang H; Xu X; Bertini E; Decher N; Wang J; Brand T; Ferlini A (07.12.2015) POPDC1S201F causes muscular dystrophy and arrhythmia by affecting protein trafficking. J Clin Invest. doi:10.1172/JCI79562. Publisher weblink  DOI.

Froese A; Breher SS; Waldeyer C; Schindler RF; Nikolaev VO; Rinné S; Wischmeyer E; Schlueter J; Becher J; Simrick S; Vauti F; Kuhtz J; Meister P; Kreissl S; Torlopp A; Liebig SK; Laakmann S; Müller TD; Neumann J; Stieber J; Ludwig A; Maier SK; Decher N; Arnold HH; Kirchhof P; Fabritz L; Brand T. (22 Feb 2012). Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking. J Clin Invest. doi: 10.1172/JCI59410.Publisher weblink  DOI.

Kirchmaier BC, Poon KL, Schwerte T, Huisken J, Winkler C, Jungblut B, Stainier DY, Brand T. (15 Mar 2012). The Popeye domain containing 2 (popdc2) gene in zebrafish is required for heart and skeletal muscle development. Dev Biol. 363:438-450 Publisher weblink DOI.

Schlueter J; Brand T. (05 May 2009). A right-sided pathway involving FGF8/Snai1 controls asymmetric development of the proepicardium in the chick embryo. Proc Natl Acad Sci U S A. 106:7485-7490. Publisher weblink DOI.

Andree B; Fleige A; Arnold HH; Brand T. (Mar 2002). Mouse Pop1 is required for muscle regeneration in adult skeletal muscle. MOL CELL BIOL. 22:1504-1512. Publisher weblink DOI.

Multimedia

Form and function of the developing heart

medicine, lecture, cardiology, heart

Publications

Journals

Reddy VK, Short SP, Barrett CW, et al., BVES Regulates Intestinal Stem Cell Programs and Intestinal Crypt 1 Viability after 2 Radiation, Stem Cells, ISSN:1549-4918

Parang B, Kaz AM, Barrett CW, et al., 2017, BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis, Gut, Vol:66, ISSN:0017-5749, Pages:852-862

Brand T, Schindler R, 2017, New kids on the block: The Popeye domain containing (POPDC) protein family acting as a novel class of cAMP effector proteins in striated muscle, Cellular Signalling, Vol:40, ISSN:0898-6568, Pages:156-165

Conference

Nelson I, Beuvin M, Ben-Yaou R, et al., 2017, Novel recessive splice site mutation in POPDC1 (BVES) is associated with first-degree atrioventricular block and muscular dystrophy, 22nd International Annual Congress of the World-Muscle-Society (WMS), PERGAMON-ELSEVIER SCIENCE LTD, Pages:S139-S140, ISSN:0960-8966

Rossi R, Scotton C, Barton P, et al., 2017, POPDC1 gene mutation screening in patients with LGMD and heart disturbances: a mutation load effect?, 22nd International Annual Congress of the World-Muscle-Society (WMS), PERGAMON-ELSEVIER SCIENCE LTD, Pages:S140-S140, ISSN:0960-8966

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