Publications
174 results found
Parang B, Kaz A, Choksi YA, et al., 2013, BVES Suppresses Inflammatory Carcinogenesis, Digestive Disease Week / 28th Annual Residents and Fellows Research Conference of the Society-for-Surgery-of-the-Alimentary-Tract (SSAT), Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: S13-S14, ISSN: 0016-5085
Poon KL, Brand T, 2013, The zebrafish model system in cardiovascular research: a tiny fish with mighty prospects, Global Cardiology Science and Practice, Vol: 2013, ISSN: 2305-7823
Schindler RF, Poon KL, Simrick S, et al., 2012, The Popeye domain containing genes: essential elements in heart rate control., Cardiovasc Diagn Ther, Vol: 2, Pages: 308-319, ISSN: 2223-3652
The Popeye domain containing (Popdc) gene family displays preferential expression in skeletal muscle and heart. Only recently a significant gain in the understanding of the function of Popdc genes in the heart has been obtained. The Popdc genes encode membrane proteins harboring an evolutionary conserved Popeye domain, which functions as a binding domain for cyclic adenosine monophosphate (cAMP). Popdc proteins interact with the two-pore channel TREK-1 and enhance its current. This protein interaction is modulated by cAMP. Null mutations of members of the Popdc gene family in zebrafish and mouse are associated with severe cardiac arrhythmia phenotypes. While in zebrafish an atrioventricular block was prevalent, in mouse a stress-induced sinus bradycardia was observed, which was due to the presence of sinus pauses. Moreover, the phenotype develops in an age-dependent manner, being absent in the young animal and becoming increasingly severe, as the animals grow older. This phenotype is reminiscent of the sick sinus syndrome (SSS), which affects mostly the elderly and is characterized by the poor ability of the cardiac pacemaker to adapt the heart rate to the physiological demand. While being a prevalent disease, which is responsible for a large fraction of pacemaker implantations in Western countries, SSS is poorly understood at the molecular level. It is therefore expected that the study of the molecular basis of the stress-induced bradycardia in Popdc mice will shed new light on the etiology of pacemaker disease.
Schlueter J, Brand T, 2012, Epicardial Progenitor Cells in Cardiac Development and Regeneration, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 5, Pages: 641-653, ISSN: 1937-5387
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- Citations: 30
Kirchmaier BC, Poon KL, Schwerte T, et al., 2012, The Popeye domain containing 2 (<i>popdc2</i>) gene in zebrafish is required for heart and skeletal muscle development (vol 363, pg 438, 2012), DEVELOPMENTAL BIOLOGY, Vol: 366, Pages: 433-433, ISSN: 0012-1606
Choksi YA, McDonough EM, Barrett CW, et al., 2012, BVES Contributes to Colonic Wound Healing After Mechanical Injury, Digestive Disease Week (DDW), Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: S74-S74, ISSN: 0016-5085
Schindler R, Simrick S, Brand T, 2012, Nuclear localization of members of the popeye domain containing (Popdc) protein family, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S98-S98, ISSN: 0008-6363
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- Citations: 10
Schlueter J, Brand T, 2012, Pericardial origin of proepicardial progenitor cells in the avian embryo, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S9-S9, ISSN: 0008-6363
Simrick S, Kreutzer R, Rao C, et al., 2012, Pronounced stress-induced lethality in popdc1/2 null mutants, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S53-S53, ISSN: 0008-6363
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- Citations: 2
Kirchmaier BC, Poon KL, Schwerte T, et al., 2012, The Popeye domain containing 2 (<i>popdc2</i>) gene in zebrafish is required for heart and skeletal muscle development, DEVELOPMENTAL BIOLOGY, Vol: 363, Pages: 438-450, ISSN: 0012-1606
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- Citations: 52
Poon KL, Kirchmaier BC, Schwerte T, et al., 2012, Aberrant skeletal muscle formation and heart function in popdc2 deficient zebrafish embryos, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S90-S90, ISSN: 0008-6363
Froese A, Breher SS, Waldeyer C, et al., 2012, Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice., J Clin Invest
Fiedler J, Jazbutyte V, Kirchmaier BC, et al., 2011, MicroRNA-24 Regulates Vascularity After Myocardial Infarction, CIRCULATION, Vol: 124, Pages: 720-U178, ISSN: 0009-7322
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- Citations: 325
Gingold-Belfer R, Bergman M, Alcalay Y, et al., 2011, <i>Popeye domain</i>-<i>containing</i> 1 is down-regulated in failing human hearts, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Vol: 27, Pages: 25-31, ISSN: 1107-3756
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- Citations: 23
Gingold-Belfer R, Bergman M, Alcalay Y, et al., 2011, Popeye domain-containing 1 is down-regulated in failing human hearts., Int J Mol Med, Vol: 27, Pages: 25-31
Congestive heart failure, a complex disease of heterogeneous etiology, involves alterations in the expression of multiple genes. The Popeye domain-containing (POPDC) family of three novel muscle-restricted genes (POPDC1-3) is evolutionarily conserved and developmentally regulated. In mice, POPDC1 has been shown to play an important role in skeletal and cardiac muscles subjected to injury or stress. However, it has never been explored in human hearts. In biopsies from non-failing and failing human hearts, we examined the cellular distribution of POPDC1 as well as the expression patterns of POPDC1-3 mRNAs. POPDC1 was visualized by immunohistochemistry and estimated by Western immunoblotting. The mRNA levels of POPDC1-3 and ß myosin heavy chain (MYHC7) were assessed using reverse transcription/quantitative polymerase chain reaction. POPDC1 was predominantly localized in the sarcolemma with an enhanced expression in the intercalated discs. In failing hearts, many cardiomyocytes appeared deformed and POPDC1 labeling was deranged. The three POPDC mRNAs were expressed in the four heart chambers with higher transcript levels in the ventricles compared to the atria. Heart failure concurred with reduced levels of POPDC1 mRNA and protein in the left ventricle. Correlation analyses of mRNA levels among the failing heart specimens indicated the coordinated regulation of POPDC1 with POPDC3 and of POPDC2 with MYHC7. It can be concluded that POPDC gene expression is modified in end-stage heart failure in humans in a manner suggesting regulatory and/or functional differences between the three family members and that POPDC1 is particularly susceptible to this condition.
Torlopp A, Schlueter J, Brand T, 2010, Role of fibroblast growth factor signaling during proepicardium formation in the chick embryo., Dev Dyn, Vol: 239, ISSN: 1097-0177
COVER PHOTOGRAPH: 3-D reconstruction of the Tbx18 expression domain demarcating the proepicardium of a HH stage 16 embryo. The proepicardium is viewed from the ventral side and is characterized by extensive outgrowth of mesothelial cells forming the typical villous structure of the proepicardium in the chick. On the left side a small Tbx18 stained proepicardium, which lacks the villous outgrowth is seen. From Torlopp et al., Developmental Dynamics 239:2393-2403, 2010.
Brand T, 2010, Exciting news: catecholamines in induction and regionalization of the heart., Cardiovasc Res, Vol: 88, Pages: 1-2
Brand T, 2010, Exciting news: catecholamines in induction and regionalization of the heart, CARDIOVASCULAR RESEARCH, Vol: 88, Pages: 1-2, ISSN: 0008-6363
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- Citations: 1
Torlopp A, Schlueter J, Brand T, 2010, Role of Fibroblast Growth Factor Signaling During Proepicardium Formation in the Chick Embryo, DEVELOPMENTAL DYNAMICS, Vol: 239, Pages: 2393-2403, ISSN: 1058-8388
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- Citations: 22
Mikawa T, Brand T, 2010, Epicardial lineage, origins and fates., Heart Development and Regeneration, Editors: Rosenthal N, Harvey RP, San Diego, Publisher: Elsevier
Schlueter J, Brand T, 2009, A right-sided pathway involving <i>FGF8</i>/<i>Snai1</i> controls asymmetric development of the proepicardium in the chick embryo, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 7485-7490, ISSN: 0027-8424
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- Citations: 40
Brand T, Froese A, Breher SS, et al., 2008, The Popeye Domain Containing 2 (Popdc2) Gene is Essential for Sinus Node Function, 81st Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S323-S323, ISSN: 0009-7322
Jahr M, Schlueter J, Brand T, et al., 2008, Development of the Proepicardium in <i>Xenopus laevis</i>, DEVELOPMENTAL DYNAMICS, Vol: 237, Pages: 3088-3096, ISSN: 1058-8388
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- Citations: 32
Gingold-Belfer R, Bergman M, Schlsinger H, et al., 2008, <i>Popeye domain containing</i> (POPDC) genes are reprogrammed in failing human hearts, 28th Annual Meeting of the European Section of the International-Society-for-Heart-Research, Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Pages: 721-721, ISSN: 0022-2828
Froese A, Brand T, 2008, Expression pattern of <i>Popdc2</i> during mouse embryogenesis and in the adult, DEVELOPMENTAL DYNAMICS, Vol: 237, Pages: 780-787, ISSN: 1058-8388
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- Citations: 20
Froese A, Brand T, 2008, Expression pattern of Popdc2 during mouse embryogenesis and in the adult., Dev Dyn, Vol: 237, Pages: 780-787, ISSN: 1058-8388
The Popdc2 gene is a member of the Popeye domain containing gene family encoding membrane proteins with prominent expression in striated and smooth muscle tissue. After introducing a LacZ reporter gene into the Popdc2 locus, expression was studied during embryonic development and postnatal life. At embryonic day (E) 7.5, expression was present in cardiac and extraembryonic mesoderm. At E10.5, expression was found in heart, somites, and mesothelial cells lining the coelom. At E12.5, expression was present in the coelomic mesothelium, pericardial and myocardial layer of the heart, skeletal muscle, bladder, gut, and umbilical vessels. Postnatal expression was found in cardiac and skeletal muscle and in the smooth muscle layer of colon, rectum, and bladder. In the stomach, Popdc2 was exclusively present in the pyloric epithelium. In conclusion, Popdc2 is expressed in various muscle and nonmuscle cell types during embryonic development and in postnatal life.
Waldeyer C, Fabritz L, Froese A, et al., 2007, Stress-induced sinus bradycardia in mice lacking Popdc2, Publisher: OXFORD UNIV PRESS, Pages: 739-739, ISSN: 0195-668X
Parnes D, Jacoby V, Sharabi A, et al., 2007, The <i>Popdc</i> gene family in the rat:: Molecular cloning, characterization and expression analysis in the heart and cultured cardiomyocytes, BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, Vol: 1769, Pages: 586-592, ISSN: 0167-4781
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- Citations: 13
Yang K, Doughman Y-Q, Zaidi S, et al., 2007, Expression analysis of CITED2 mRNA during chicken heart development, Experimental Biology 2007 Annual Meeting, Publisher: FEDERATION AMER SOC EXP BIOL, Pages: A200-A200, ISSN: 0892-6638
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