Imperial College London
Alternate

ProfessorThomasBrand

Faculty of Medicine, National Heart & Lung Institute

Chair in Developmental Dynamics
 
 
 
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Contact

 

+44 (0)20 7594 8744t.brand Website CV

 
 
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Assistant

 

Miss Cheryl Costello +44 (0)20 7594 3001

 
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Location

 

433ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Swan:2019:10.1007/s10974-019-09523-z,
author = {Swan, A and Gruscheski, L and Boland, L and Brand, T},
doi = {10.1007/s10974-019-09523-z},
journal = {Journal of Muscle Research and Cell Motility},
pages = {169--183},
title = {The Popeye domain containing gene family encoding a family of cAMP-effector proteins with important functions in striated muscle and beyond},
url = {http://dx.doi.org/10.1007/s10974-019-09523-z},
volume = {40},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The Popeye domain containing (POPDC) gene family encodes a novel class of membrane-bound cyclic AMP effector proteins. POPDC proteins are abundantly expressed in cardiac and skeletal muscle. Consistent with its predominant expression in striated muscle, Popdc1 and Popdc2 null mutants in mouse and zebrafish develop cardiac arrhythmia and muscular dystrophy. Likewise, mutations in POPDC genes in patients have been associated with cardiac arrhythmia and muscular dystrophy phenotypes. A membrane trafficking function has been identified in this context. POPDC proteins have also been linked to tumour formation. Here, POPDC1 plays a role as a tumour suppressor by limiting c-Myc and WNT signalling. Currently, a common functional link between POPDC’s role in striated muscle and as a tumour suppressor is lacking. We also discuss several alternative working models to better understand POPDC protein function.
AU  - Swan,A
AU  - Gruscheski,L
AU  - Boland,L
AU  - Brand,T
DO  - 10.1007/s10974-019-09523-z
EP  - 183
PY  - 2019///
SN  - 0142-4319
SP  - 169
TI  - The Popeye domain containing gene family encoding a family of cAMP-effector proteins with important functions in striated muscle and beyond
T2  - Journal of Muscle Research and Cell Motility
UR  - http://dx.doi.org/10.1007/s10974-019-09523-z
UR  - https://link.springer.com/article/10.1007%2Fs10974-019-09523-z
UR  - http://hdl.handle.net/10044/1/71559
VL  - 40
ER  -
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