Imperial College London
Alternate

ProfessorThomasBrand

Faculty of Medicine, National Heart & Lung Institute

Chair in Developmental Dynamics
 
 
 
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Contact

 

+44 (0)20 7594 8744t.brand Website CV

 
 
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Assistant

 

Miss Cheryl Costello +44 (0)20 7594 3001

 
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Location

 

433ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brand:2016:10.1016/j.pbiomolbio.2016.01.001,
author = {Brand, T and Schindler, RF},
doi = {10.1016/j.pbiomolbio.2016.01.001},
journal = {Progress in Biophysics and Molecular Biology},
pages = {28--36},
title = {The Popeye domain containing protein family - a novel class of cAMP effectors with important functions in multiple tissues.},
url = {http://dx.doi.org/10.1016/j.pbiomolbio.2016.01.001},
volume = {120},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Popeye domain containing (Popdc) proteins are a unique family, which combine several different properties and functions in a surprisingly complex fashion. They are expressed in multiple tissues and cell types, present in several subcellular compartments, interact with different classes of proteins, and are associated with a variety of physiological and pathophysiological processes. Moreover, Popdc proteins bind the second messenger cAMP with high affinity and it is thought that they act as a novel class of cAMP effector proteins. Here, we will review the most important findings about the Popdc family, which have been accumulated since its discovery about 15 years ago. We will be focusing on Popdc protein interaction and function in striated muscle tissue. However, as a full picture only emerges if all aspects aretaken into account, we will also describe what is currently known about the role of Popdc proteins in epithelial cells and in various types of cancer, and discuss these findings with regard to their relevance for heart and skeletal muscle.
AU  - Brand,T
AU  - Schindler,RF
DO  - 10.1016/j.pbiomolbio.2016.01.001
EP  - 36
PY  - 2016///
SN  - 1873-1732
SP  - 28
TI  - The Popeye domain containing protein family - a novel class of cAMP effectors with important functions in multiple tissues.
T2  - Progress in Biophysics and Molecular Biology
UR  - http://dx.doi.org/10.1016/j.pbiomolbio.2016.01.001
UR  - http://hdl.handle.net/10044/1/28850
VL  - 120
ER  -
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