Imperial College London
Alternate

ProfessorThomasBrand

Faculty of Medicine, National Heart & Lung Institute

Chair in Developmental Dynamics
 
 
 
//

Contact

 

+44 (0)20 7594 8744t.brand Website CV

 
 
//

Assistant

 

Miss Cheryl Costello +44 (0)20 7594 3001

 
//

Location

 

433ICTEM buildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Schindler:2016:10.3390/jcdd3020022,
author = {Schindler, RFR and Scotton, C and French, V and Ferlini, A and Brand, T and Schindler, RFR and Scotton, C and French, V and Ferlini, A and Brand, T},
doi = {10.3390/jcdd3020022},
journal = {Journal of cardiovascular development and disease},
title = {The Popeye Domain Containing Genes and Their Function in Striated Muscle.},
url = {http://dx.doi.org/10.3390/jcdd3020022},
volume = {3},
year = {2016}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The Popeye domain containing (POPDC) genes encode a novel class of cAMP effector proteins, which are abundantly expressed in heart and skeletal muscle. Here, we will review their role in striated muscle as deduced from work in cell and animal models and the recent analysis of patients carrying a missense mutation in POPDC1. Evidence suggests that POPDC proteins control membrane trafficking of interacting proteins. Furthermore, we will discuss the current catalogue of established protein-protein interactions. In recent years, the number of POPDC-interacting proteins has been rising and currently includes ion channels (TREK-1), sarcolemma-associated proteins serving functions in mechanical stability (dystrophin), compartmentalization (caveolin 3), scaffolding (ZO-1), trafficking (NDRG4, VAMP2/3) and repair (dysferlin) or acting as a guanine nucleotide exchange factor for Rho-family GTPases (GEFT). Recent evidence suggests that POPDC proteins might also control the cellular level of the nuclear proto-oncoprotein c-Myc. These data suggest that this family of cAMP-binding proteins probably serves multiple roles in striated muscle.
AU  - Schindler,RFR
AU  - Scotton,C
AU  - French,V
AU  - Ferlini,A
AU  - Brand,T
AU  - Schindler,RFR
AU  - Scotton,C
AU  - French,V
AU  - Ferlini,A
AU  - Brand,T
DO  - 10.3390/jcdd3020022
PY  - 2016///
SN  - 2308-3425
TI  - The Popeye Domain Containing Genes and Their Function in Striated Muscle.
T2  - Journal of cardiovascular development and disease
UR  - http://dx.doi.org/10.3390/jcdd3020022
UR  - http://hdl.handle.net/10044/1/33839
VL  - 3
ER  -
Download