Imperial College London
Alternate

ProfessorThomasBrand

Faculty of Medicine, National Heart & Lung Institute

Chair in Developmental Dynamics
 
 
 
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Contact

 

+44 (0)20 7594 8744t.brand Website CV

 
 
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Assistant

 

Miss Cheryl Costello +44 (0)20 7594 3001

 
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Location

 

433ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brand:2017:10.1016/j.cellsig.2017.09.015,
author = {Brand, T and Schindler},
doi = {10.1016/j.cellsig.2017.09.015},
journal = {Cellular Signalling},
pages = {156--165},
title = {New kids on the block: The Popeye domain containing (POPDC) protein family acting as a novel class of cAMP effector proteins in striated muscle},
url = {http://dx.doi.org/10.1016/j.cellsig.2017.09.015},
volume = {40},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The cyclic 3’,5’-adenosine monophosphate (cAMP) signalling pathway constitutes an ancient signal transduction pathway present in prokaryotes and eukaryotes. Previously, it was thought that in eukaryotes three effector proteins mediate cAMP signalling, namely protein kinase A (PKA), exchange factor directly activated by cAMP (EPAC) and the cyclic-nucleotide gated channels. However, recently a novel family of cAMP effector proteins emerged and was termed the Popeye domain containing (POPDC) family, which consists of three members POPDC1, POPDC2 and POPDC3. POPDC proteins are transmembrane proteins, which are abundantly present in striated and smooth muscle cells. POPDC proteins bind cAMP with high affinity comparable to PKA. Presently, their biochemical activity is poorly understood. However, mutational analysis in animal models as well as the disease phenotype observed in patients carrying missense mutations suggests that POPDC proteins are acting by modulating membrane trafficking of interacting proteins. In this review, we will describe the current knowledge about this gene family and also outline the apparent gaps in our understanding of their role in cAMP signalling and beyond.
AU  - Brand,T
AU  - Schindler
DO  - 10.1016/j.cellsig.2017.09.015
EP  - 165
PY  - 2017///
SN  - 0898-6568
SP  - 156
TI  - New kids on the block: The Popeye domain containing (POPDC) protein family acting as a novel class of cAMP effector proteins in striated muscle
T2  - Cellular Signalling
UR  - http://dx.doi.org/10.1016/j.cellsig.2017.09.015
UR  - http://hdl.handle.net/10044/1/50886
VL  - 40
ER  -
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