Imperial College London
Portrait Picture

Professor Tony Cass

Faculty of Natural Sciences, Department of Chemistry

Senior Research Investigator
 
 
 
//

Contact

 

+44 (0)20 7594 5195t.cass

 
 
//

Location

 

301KMolecular Sciences Research HubWhite City Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Piersimoni:2020:10.1039/d0na00688b,
author = {Piersimoni, ME and Teng, X and Cass, AEG and Ying, L},
doi = {10.1039/d0na00688b},
journal = {Nanoscale Advances},
pages = {5666--5681},
title = {Antioxidant lipoic acid ligand-shell gold nanoconjugates against oxidative stress caused by α-Synuclein aggregates},
url = {http://dx.doi.org/10.1039/d0na00688b},
volume = {2},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Gold nanoparticle is becoming a promising platform for the delivery of drugs to treat neurodegenerative diseases. Parkinson’s disease, associated with the aggregation of α-synuclein, is a condition that results in dysfunctional neuronal cells leading to their degeneration and death. Oxidative stress has been strongly implicated as a common feature in this process. The limited efficacy of the traditional therapies and the development of associated severe side effects present an unmet need for preventive and adjuvant therapies. The organosulfur compound lipoic acid, naturally located in the mitochondria, plays a powerful antioxidative role against oxidative stress. However, the efficacy is limited by its low physiological concentration, and the administration is affected by its short half-life and bioavailability due to hepatic degradation. Here we exploited the drug delivery potential of gold nanoparticles to assemble lipoic acid, and administered the system to SH-SY5Y cells, a cellular model commonly used to study Parkinson’s disease. We tested the nanoconjugates, termed GNPs-LA, under an oxidative environment induced by gold nanoparticle/α-synuclein conjugates (GNPs-α-Syn). GNPs-LA were found to be biocompatible and capable of restoring the cell damage caused by high-level reactive oxygen species generated by excessive oxidative stress in the cellular environment. We conclude that GNPs-LA may serve as a promising drug delivery vehicle conveying antioxidant molecules for the treatment of Parkinson’s disease.
AU  - Piersimoni,ME
AU  - Teng,X
AU  - Cass,AEG
AU  - Ying,L
DO  - 10.1039/d0na00688b
EP  - 5681
PY  - 2020///
SN  - 2516-0230
SP  - 5666
TI  - Antioxidant lipoic acid ligand-shell gold nanoconjugates against oxidative stress caused by α-Synuclein aggregates
T2  - Nanoscale Advances
UR  - http://dx.doi.org/10.1039/d0na00688b
UR  - https://pubs.rsc.org/en/Content/ArticleLanding/2020/NA/D0NA00688B
UR  - http://hdl.handle.net/10044/1/83550
VL  - 2
ER  -
Download