Imperial College London
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Professor Timothy Constandinou

Faculty of Engineering, Department of Electrical and Electronic Engineering

Professor of Bioelectronics
 
 
 
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Contact

 

+44 (0)20 7594 0790t.constandinou Website

 
 
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Assistant

 

Miss Izabela Wojcicka-Grzesiak +44 (0)20 7594 0701

 
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Location

 

B407Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Firfilionis:2021:10.3389/fnins.2021.718311,
author = {Firfilionis, D and Hutchings, F and Tamadoni, R and Walsh, D and Turnbull, M and Escobedo-Cousin, E and Bailey, RG and Gausden, J and Patel, A and Haci, D and Liu, Y and LeBeau, FEN and Trevelyan, A and Constandinou, TG and O'Neill, A and Kaiser, M and Degenaar, P and Jackson, A},
doi = {10.3389/fnins.2021.718311},
journal = {Frontiers in Neuroscience},
pages = {1--10},
title = {A closed-loop optogenetic platform},
url = {http://dx.doi.org/10.3389/fnins.2021.718311},
volume = {15},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Neuromodulation is an established treatment for numerous neurological conditions, but to expand the therapeutic scope there is a need to improve the spatial, temporal and cell-type specificity of stimulation. Optogenetics is a promising area of current research, enabling optical stimulation of genetically-defined cell types without interfering with concurrent electrical recording for closed-loop control of neural activity. We are developing an open-source system to provide a platform for closed-loop optogenetic neuromodulation, incorporating custom integrated circuitry for recording and stimulation, real-time closed-loop algorithms running on a microcontroller and experimental control via a PC interface. We include commercial components to validate performance, with the ultimate aim of translating this approach to humans. In the meantime our system is flexible and expandable for use in a variety of preclinical neuroscientific applications. The platform consists of a Controlling Abnormal Network Dynamics using Optogenetics (CANDO) Control System (CS) that interfaces with up to four CANDO headstages responsible for electrical recording and optical stimulation through custom CANDO LED optrodes. Control of the hardware, inbuilt algorithms and data acquisition is enabled via the CANDO GUI (Graphical User Interface). Here we describe the design and implementation of this system, and demonstrate how it can be used to modulate neuronal oscillations in vitro and in vivo.
AU  - Firfilionis,D
AU  - Hutchings,F
AU  - Tamadoni,R
AU  - Walsh,D
AU  - Turnbull,M
AU  - Escobedo-Cousin,E
AU  - Bailey,RG
AU  - Gausden,J
AU  - Patel,A
AU  - Haci,D
AU  - Liu,Y
AU  - LeBeau,FEN
AU  - Trevelyan,A
AU  - Constandinou,TG
AU  - O'Neill,A
AU  - Kaiser,M
AU  - Degenaar,P
AU  - Jackson,A
DO  - 10.3389/fnins.2021.718311
EP  - 10
PY  - 2021///
SN  - 1662-453X
SP  - 1
TI  - A closed-loop optogenetic platform
T2  - Frontiers in Neuroscience
UR  - http://dx.doi.org/10.3389/fnins.2021.718311
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000698798700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.frontiersin.org/articles/10.3389/fnins.2021.718311/full
UR  - http://hdl.handle.net/10044/1/92958
VL  - 15
ER  -
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