I am a clinician scientist and Wellcome Trust Intermediate Clinical Fellow, currently based at the MRC Unit The Gambia as a PI in the Vaccines and Immunity Theme lead by Professor Beate Kampmann. My primary interest is the study of anti-viral immune responses in the context of both vaccination and natural infection. The focus of my current research is the detailed mucosal and systemic immunogenicity of live attenuated influenza vaccine (LAIV) in Gambian children using a systems vaccinology approach, including interactions with the host nasopharyngeal microbiome.
I completed my undergraduate medical training at the University of Bristol in 2000, followed by postgraduate clinical training in General Internal Medicine, Infectious Diseases and HIV in Oxford and London. I then moved to Sheffield for higher specialist training in Infectious Diseases & Microbiology. I was awarded a British Infection Society Research Fellowship (2007-8), followed by an MRC Clinical Research Training Fellowship (2008 – 11) to undertake my PhD studies under the supervision of Professor Sarah Rowland-Jones (Oxford) and Professor Robin Weiss (UCL) on the pathogenesis of HIV-2 infection and molecular epidemiology of HIV in The Gambia and Guinea-Bissau.
As an NIHR Academic Clinical Lecturer in Infectious Diseases & Microbiology at the University of Sheffield, I was awarded an Academy of Medical Sciences starter grant to undertake pilot studies of LAIV immunogenicity in adult volunteers. Data generated during these lead to the successful award of a Wellcome Trust Intermediate Clinical Fellowship in 2016 to be undertaken between Imperial College London, the MRC Unit The Gambia, Public Health England laboratories in Colindale and the University of Edinburgh.
I am an Honorary Consultant Physician in Infectious Diseases in the Dept. of Infection and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust and Honorary Senior Clinical Lecturer at the University of Sheffield.
et al., 2019, Effect of a Russian-backbone live-attenuated influenza vaccine with an updated pandemic H1N1 strain on shedding and immunogenicity among children in The Gambia: an open-label, observational, phase 4 study, Lancet Respiratory Medicine, Vol:7, ISSN:2213-2600, Pages:665-676
et al., 2019, The efficacy, effectiveness, and immunogenicity of influenza vaccines in Africa: a systematic review (vol 19, pg e110, 2019), Lancet Infectious Diseases, Vol:19, ISSN:1473-3099, Pages:E187-E187
et al., 2019, Genomic and Epidemiological Evidence of a Dominant Panton-Valentine Leucocidin-Positive Methicillin Resistant Staphylococcus aureus Lineage in Sri Lanka and Presence Among Isolates From the United Kingdom and Australia, Frontiers in Cellular and Infection Microbiology, Vol:9, ISSN:2235-2988
et al., 2019, A comparison of viral microneutralization and haemagglutination inhibition assays as measures of seasonal inactivated influenza vaccine immunogenicity in the first year after reduced intensity conditioning, lymphocyte depleted allogeneic haematopoietic stem cell transplant, Vaccine, Vol:37, ISSN:0264-410X, Pages:452-457
et al., 2019, Low-bias RNA sequencing of the HIV-2 genome from blood plasma, Journal of Virology, Vol:93, ISSN:1098-5514
et al., 2018, HLA-associated polymorphisms in the HIV-2 capsid highlight key differences between HIV-1 and HIV-2 immune adaptation, AIDS, Vol:32, ISSN:0269-9370, Pages:709-714
et al., 2018, Acceptability of intranasal live attenuated influenza vaccine, influenza knowledge and vaccine intent in The Gambia, Vaccine, Vol:36, ISSN:0264-410X, Pages:1772-1780
et al., 2017, Comparison of mucosal lining fluid sampling methods and influenza-specific IgA detection assays for use in human studies of influenza immunity, Journal of Immunological Methods, Vol:449, ISSN:0022-1759, Pages:1-6
de Silva TI, Kampmann B, 2017, Value of immunogenicity studies of influenza vaccinein resource-limited settings, The Lancet Global Health, Vol:5, ISSN:2214-109X, Pages:E274-E274
et al., 2017, Routine vaccination practice after adult and paediatric allogeneic haematopoietic stem cell transplant: a survey of UK NHS programmes., Bone Marrow Transplantation, Vol:52, ISSN:1476-5365, Pages:775-777
et al., 2016, Viral evolution and cytotoxic T cell restricted selection in acute infant HIV-1 infection, Scientific Reports, Vol:6, ISSN:2045-2322
et al., 2015, Predicting the extinction of HIV-2 in rural Guinea-Bissau, AIDS, Vol:29, ISSN:0269-9370, Pages:2479-2486
et al., 2015, Early virological and immunological events in asymptomatic Epstein-Barr virus infection in African children, PLOS Pathogens, Vol:11, ISSN:1553-7366
et al., 2013, Correlates of T-cell-mediated viral control and phenotype of CD8(+) T cells in HIV-2, a naturally contained human retroviral infection, Blood, Vol:121, ISSN:0006-4971, Pages:4330-4339
et al., 2013, Population dynamics of HIV-2 in rural West Africa: comparison with HIV-1 and ongoing transmission at the heart of the epidemic, AIDS, Vol:27, ISSN:0269-9370, Pages:125-134
et al., 2012, Monocytes Regulate the Mechanism of T-cell Death by Inducing Fas-Mediated Apoptosis during Bacterial Infection, Plos Pathogens, Vol:8, ISSN:1553-7374
et al., 2012, Maternal Proviral Load and Vertical Transmission of Human T Cell Lymphotropic Virus Type 1 in Guinea-Bissau, AIDS Research and Human Retroviruses, Vol:28, ISSN:0889-2229, Pages:584-590
et al., 2012, Molecular Epidemiology of Endemic Human T-Lymphotropic Virus Type 1 in a Rural Community in Guinea-Bissau, PLOS Neglected Tropical Diseases, Vol:6, ISSN:1935-2735
et al., 2012, T-cell immunity to Kaposi sarcoma–associated herpesvirus: recognition of primary effusion lymphoma by LANA-specific CD4+ T cells, Blood, Vol:119, ISSN:0006-4971, Pages:2083-2092
et al., 2012, Potent Autologous and Heterologous Neutralizing Antibody Responses Occur in HIV-2 Infection across a Broad Range of Infection Outcomes, Journal of Virology, Vol:86, ISSN:0022-538X, Pages:930-946
et al., 2011, Mortality and immunovirological outcomes on antiretroviral therapy in HIV-1 and HIV-2-infected individuals in the Gambia, AIDS, Vol:25, ISSN:0269-9370, Pages:2167-2175
et al., 2010, HIV-1 subtype distribution in the Gambia and the significant presence of CRF49_cpx, a novel circulating recombinant form, Retrovirology, Vol:7, ISSN:1742-4690
de Silva TI, Cotten M, Rowland-Jones SL, 2008, HIV-2: the forgotten AIDS virus, Trends in Microbiology, Vol:16, ISSN:0966-842X, Pages:588-595