Imperial College London

DrTimothyEbbels

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Reader in Computational Bioinformatics
 
 
 
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Contact

 

+44 (0)20 7594 3160t.ebbels Website

 
 
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Location

 

131Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

139 results found

Lindon JC, Keun HC, Ebbels TMD, Pearce JTM, Holmes EC, Nicholson JKet al., 2005, The Consortium for Metabonomic Toxicology (comet): aims, activities and achievements., Pharmacogenomics, Vol: 6, Pages: 691-9

The utility of metabonomics in the evaluation of xenobiotic toxicity has been comprehensively assessed by the Consortium for Metabonomic Toxicology (COMET), formed between five major pharmaceutical companies and Imperial College London, UK. The main objectives were to assess methodologies, to generate a metabonomic database using (1)H nuclear magnetic resonance (NMR) spectroscopy of rodent urine and blood serum and to build a predictive expert system for target organ toxicity. The analytic and biologic variation that might arise through the use of metabonomics was evaluated and a high degree of robustness demonstrated. With the completion of 147 studies, the chief deliverables of a curated database of rodent biofluid NMR spectra and computer-based expert systems for the prediction of kidney or liver toxicity in rat and mouse based on the spectral data have been generated, and delivered to the sponsoring companies. The project, with its relatively modest resources, has met and exceeded all of its targets and was judged a resounding success by the sponsoring companies who are, in many cases, already enhancing and making use of the data in their in-house studies.

Journal article

Ebbels TMD, Holmes E, Lindon JC, Nicholson JKet al., 2004, Evaluation of metabolic variation in normal rat strains from a statistical analysis of (1)H NMR spectra of urine, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol: 36, Pages: 823-833, ISSN: 0731-7085

Journal article

Keun HC, Ebbels TMD, Bollard ME, Beckonert O, Antti H, Holmes E, Lindon JC, Nicholson JKet al., 2004, Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles, CHEMICAL RESEARCH IN TOXICOLOGY, Vol: 17, Pages: 579-587, ISSN: 0893-228X

Journal article

Ebbels TMD, Lindon JC, Nicholson JK, Holmes Eet al., 2004, Methods for spectral analysis and their applications: spectral replacement, US 6,683,455

Patent

Antti H, Ebbels TMD, Keun H, Bollard ME, Beckonert O, Lindon JC, Nicholson JK, Holmes Eet al., 2004, Statistical experimental design and partial least squares regression analysis of biofluid metabonomic NMR and clinical chemistry data for assessment of adverse drug effects, Chemometrics & Intelligent Laboratory Systems, Pages: 139-149

Journal article

Wang YL, Bollard ME, Keun H, Antti H, Beckonert O, Ebbels TM, Lindon JC, Holmes E, Tang HR, Nicholson JKet al., 2003, Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning H-1 nuclear magnetic resonance spectroscopy of liver tissues, ANALYTICAL BIOCHEMISTRY, Vol: 323, Pages: 26-32, ISSN: 0003-2697

Journal article

Lindon JC, Nicholson JK, Holmes E, Antti H, Bollard ME, Keun H, Beckonert O, Ebbels TM, Reilly MD, Robertson D, Stevens GJ, Luke P, Breau AP, Cantor GH, Bible RH, Niederhauser U, Senn H, Schlotterbeck G, Sidelmann UG, Laursen SM, Tymiak A, Car BD, Lehman-McKeeman L, Colet JM, Loukaci A, Thomas Cet al., 2003, Contemporary issues in toxicology - The role of metabonomics in toxicology and its evaluation by the COMET project, TOXICOLOGY AND APPLIED PHARMACOLOGY, Vol: 187, Pages: 137-146, ISSN: 0041-008X

Journal article

Warne MA, Ebbels TMD, Lindon JC, Nicholson JKet al., 2003, Semiempirical molecular-orbital properties of some polycyclic aromatic hydrocarbons and correlation with environmental toxic equivalency factors, POLYCYCLIC AROMATIC COMPOUNDS, Vol: 23, Pages: 23-47, ISSN: 1040-6638

Journal article

Beckonert O, Bollard ME, Ebbels TMD, Keun H, Antti H, Holmes E, Lindon JC, Nicholson JKet al., 2003, NMR-based metabonomic toxicity classification: hierarchical cluster analysis and K-nearest-neighbour approaches, Analytica Chimica Acta, Pages: 3-15

Journal article

Keun H, Ebbels TMD, Antti H, Bollard ME, Beckonert O, Holmes E, Lindon JC, Nicholson JKet al., 2003, Improved analysis of multivariate data by variable stability (VAST) scaling: application to NMR-based metabolic profiling, Analytica Chimica Acta, Pages: 265-276

Journal article

Ebbels T, Keun H, Beckonert O, Bollard M, Holmes E, Lindon JC, Nicholson JKet al., 2003, Toxicity classification from metabonomic data using a density superposition approach: "CLOUDS", Analytica Chimica Acta

Journal article

Keun HC, Ebbels TMD, Antti H, Bollard ME, Beckonert O, Schlotterbeck G, Senn H, Niederhauser U, Holmes E, Lindon JC, Nicholson JKet al., 2002, Analytical reproducibility in H-1 NMR-based metabonomic urinalysis, CHEMICAL RESEARCH IN TOXICOLOGY, Vol: 15, Pages: 1380-1386, ISSN: 0893-228X

Journal article

Antti H, Bollard ME, Ebbels TM, Keun H, Lindon JC, Nicholson JK, Holmes Eet al., 2002, Batch statistical processing of H NMR-derived urinary spectral data, J Chemometrics, Vol: 16, Pages: 461-468, ISSN: 0886-9383

Journal article

Ebbels, T M D, Lindon J C, Nicholson J K, Holmes Eet al., 2002, Methods for spectral analysis and their applications: spectral replacement, US20010029380 [US2002145425]

Patent

Ebbels TMD, Lindon JC, Nicholson JK, 2001, Quantitative investigation of probabilistic spectral processing methods using simulated NMR spectroscopic data, Appl Spectrosc, Vol: 55, Pages: 1214-1224, ISSN: 0003-7028

Journal article

Bezecourt J, Kneib JP, Soucail G, Ebbels TMDet al., 1999, Lensed galaxies in Abell 370 - I. Modeling the number counts and redshift distribution of background sources, ASTRONOMY & ASTROPHYSICS, Vol: 347, Pages: 21-29, ISSN: 0004-6361

Journal article

Pello R, Kneib JP, Le Borgne JF, Bezecourt J, Ebbels TM, Tijera I, Bruzual G, Miralles JM, Smail I, Soucail G, Bridges TJet al., 1999, Two multiple-imaged z=4.05 galaxies in the cluster-lens Abell 2390, ASTRONOMY & ASTROPHYSICS, Vol: 346, Pages: 359-368, ISSN: 1432-0746

Journal article

Ebbels T, Ellis R, Kneib JP, Le Borgne JF, Pello R, Smail I, Sanahuja Bet al., 1998, Spectroscopic confirmation of redshifts predicted by gravitational lensing, MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Vol: 295, Pages: 75-91, ISSN: 0035-8711

Journal article

Ebbels TMD, LeBorgne JF, Pello R, Ellis RS, Kneib JP, Smail I, Sanahuja Bet al., 1996, Identification of a gravitationally lensed z=2.515 star-forming galaxy, MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Vol: 281, Pages: L75-L81, ISSN: 0035-8711

Journal article

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