Imperial College London

DrTimothyEbbels

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Reader in Computational Bioinformatics
 
 
 
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Contact

 

+44 (0)20 7594 3160t.ebbels Website

 
 
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Location

 

131Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Elliott:2015:10.1126/scitranslmed.aaa5680,
author = {Elliott, P and Posma, JM and Chan, Q and Garcia-Perez, I and Wijeyesekera, A and Bictash, M and Ebbels, TMD and Ueshima, H and Zhao, L and van, Horn L and Daviglus, M and Stamler, J and Holmes, E and Nicholson, JK},
doi = {10.1126/scitranslmed.aaa5680},
journal = {Science Translational Medicine},
pages = {1--16},
title = {Urinary metabolic signatures of human adiposity},
url = {http://dx.doi.org/10.1126/scitranslmed.aaa5680},
volume = {7},
year = {2015}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Obesity is a major public health problem worldwide. We used 24-hour urinary metabolic profiling by proton (1H) nuclear magnetic resonance (NMR) spectroscopy and ion exchange chromatography to characterize the metabolic signatures of adiposity in the U.S. (n = 1880) and UK (n = 444) cohorts of the INTERMAP (International Study of Macro- and Micronutrients and Blood Pressure) epidemiologic study. Metabolic profiling of urine samples collected over two 24-hour time periods 3 weeks apart showed reproducible patterns of metabolite excretion associated with adiposity. Exploratory analysis of the urinary metabolome using 1H NMR spectroscopy of the U.S. samples identified 29 molecular species, clustered in interconnecting metabolic pathways, that were significantly associated (P = 1.5 × 10−5 to 2.0 × 10−36) with body mass index (BMI); 25 of these species were also found in the UK validation cohort. We found multiple associations between urinary metabolites and BMI including urinary glycoproteins and N-acetyl neuraminate (related to renal function), trimethylamine, dimethylamine, 4-cresyl sulfate, phenylacetylglutamine and 2-hydroxyisobutyrate (gut microbial co-metabolites), succinate and citrate (tricarboxylic acid cycle intermediates), ketoleucine and the ketoleucine/leucine ratio (linked to skeletal muscle mitochondria and branched-chain amino acid metabolism), ethanolamine (skeletal muscle turnover), and 3-methylhistidine (skeletal muscle turnover and meat intake). We mapped the multiple BMI-metabolite relationships as part of an integrated systems network that describes the connectivities between the complex pathway and compartmental signatures of human adiposity.
AU - Elliott,P
AU - Posma,JM
AU - Chan,Q
AU - Garcia-Perez,I
AU - Wijeyesekera,A
AU - Bictash,M
AU - Ebbels,TMD
AU - Ueshima,H
AU - Zhao,L
AU - van,Horn L
AU - Daviglus,M
AU - Stamler,J
AU - Holmes,E
AU - Nicholson,JK
DO - 10.1126/scitranslmed.aaa5680
EP - 16
PY - 2015///
SN - 1946-6234
SP - 1
TI - Urinary metabolic signatures of human adiposity
T2 - Science Translational Medicine
UR - http://dx.doi.org/10.1126/scitranslmed.aaa5680
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000353784700005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://stm.sciencemag.org/content/7/285/285ra62
UR - http://hdl.handle.net/10044/1/79045
VL - 7
ER -