Imperial College London

DrTimothyEbbels

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Reader in Computational Bioinformatics
 
 
 
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Contact

 

+44 (0)20 7594 3160t.ebbels Website

 
 
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Location

 

131Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chan:2016:10.1038/hr.2016.164,
author = {Chan, Q and Loo, RL and Ebbels, TMD and Van, Horn L and Daviglus, ML and Stamler, J and Nicholson, JK and Holmes, E and Elliott, P},
doi = {10.1038/hr.2016.164},
journal = {Hypertension Research},
pages = {336--345},
title = {Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: An overview},
url = {http://dx.doi.org/10.1038/hr.2016.164},
volume = {40},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The aetiopathogenesis of cardiovascular diseases (CVD) is multifactorial. Adverse bloodpressure (BP) is a major independent risk factor for epidemic CVD affecting about 40% of theadult population worldwide and resulting in significant morbidity and mortality. Metabolicphenotyping of biological fluids has proven its application in characterising low moleculeweight metabolites providing novel insights into gene-environmental-gut microbiomeinteraction in relations to a disease state. In this review, we synthesise key results from theInternational Study of Macro/Micronutrients and Blood Pressure (INTERMAP) Study, a cross-sectional epidemiological study of 4,680 men and women aged 40-59 years from Japan, thePeople’s Republic of China, the United Kingdom, and the United States. We describe theadvancements we have made on: 1) analytical techniques for high throughput metabolicphenotyping; 2) statistical analyses for biomarker identification; 3) discovery of unique food-specific biomarkers; and 4) application of metabolome-wide association (MWA) studies togain a better understanding into the molecular mechanisms of cross cultural and regional BPdifferences.
AU - Chan,Q
AU - Loo,RL
AU - Ebbels,TMD
AU - Van,Horn L
AU - Daviglus,ML
AU - Stamler,J
AU - Nicholson,JK
AU - Holmes,E
AU - Elliott,P
DO - 10.1038/hr.2016.164
EP - 345
PY - 2016///
SN - 1348-4214
SP - 336
TI - Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: An overview
T2 - Hypertension Research
UR - http://dx.doi.org/10.1038/hr.2016.164
UR - http://hdl.handle.net/10044/1/41287
VL - 40
ER -