Publications
170 results found
Lindon JC, Keun HC, Ebbels TMD, et al., 2005, The Consortium for Metabonomic Toxicology (comet): aims, activities and achievements., Pharmacogenomics, Vol: 6, Pages: 691-9
The utility of metabonomics in the evaluation of xenobiotic toxicity has been comprehensively assessed by the Consortium for Metabonomic Toxicology (COMET), formed between five major pharmaceutical companies and Imperial College London, UK. The main objectives were to assess methodologies, to generate a metabonomic database using (1)H nuclear magnetic resonance (NMR) spectroscopy of rodent urine and blood serum and to build a predictive expert system for target organ toxicity. The analytic and biologic variation that might arise through the use of metabonomics was evaluated and a high degree of robustness demonstrated. With the completion of 147 studies, the chief deliverables of a curated database of rodent biofluid NMR spectra and computer-based expert systems for the prediction of kidney or liver toxicity in rat and mouse based on the spectral data have been generated, and delivered to the sponsoring companies. The project, with its relatively modest resources, has met and exceeded all of its targets and was judged a resounding success by the sponsoring companies who are, in many cases, already enhancing and making use of the data in their in-house studies.
Ebbels TMD, Holmes E, Lindon JC, et al., 2004, Evaluation of metabolic variation in normal rat strains from a statistical analysis of <SUP>1</SUP>H NMR spectra of urine, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol: 36, Pages: 823-833, ISSN: 0731-7085
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- Citations: 27
Keun HC, Ebbels TMD, Bollard ME, et al., 2004, Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles, CHEMICAL RESEARCH IN TOXICOLOGY, Vol: 17, Pages: 579-587, ISSN: 0893-228X
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- Citations: 115
Ebbels TMD, Lindon JC, Nicholson JK, et al., 2004, Methods for spectral analysis and their applications: spectral replacement, US 6,683,455
Antti H, Ebbels TMD, Keun H, et al., 2004, Statistical experimental design and partial least squares regression analysis of biofluid metabonomic NMR and clinical chemistry data for assessment of adverse drug effects, Chemometrics & Intelligent Laboratory Systems, Pages: 139-149
Wang YL, Bollard ME, Keun H, et al., 2003, Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning <SUP>1</SUP>H nuclear magnetic resonance spectroscopy of liver tissues, ANALYTICAL BIOCHEMISTRY, Vol: 323, Pages: 26-32, ISSN: 0003-2697
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- Citations: 127
Lindon JC, Nicholson JK, Holmes E, et al., 2003, Contemporary issues in toxicology - The role of metabonomics in toxicology and its evaluation by the COMET project, TOXICOLOGY AND APPLIED PHARMACOLOGY, Vol: 187, Pages: 137-146, ISSN: 0041-008X
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- Citations: 300
Beckonert O, Bollard ME, Ebbels TMD, et al., 2003, NMR-based metabonomic toxicity classification: hierarchical cluster analysis and K-nearest-neighbour approaches, Analytica Chimica Acta, Pages: 3-15
Ebbels T, Keun H, Beckonert O, et al., 2003, Toxicity classification from metabonomic data using a density superposition approach: "CLOUDS", Analytica Chimica Acta
Keun H, Ebbels TMD, Antti H, et al., 2003, Improved analysis of multivariate data by variable stability (VAST) scaling: application to NMR-based metabolic profiling, Analytica Chimica Acta, Pages: 265-276
Warne MA, Ebbels TMD, Lindon JC, et al., 2003, Semiempirical molecular-orbital properties of some polycyclic aromatic hydrocarbons and correlation with environmental toxic equivalency factors, POLYCYCLIC AROMATIC COMPOUNDS, Vol: 23, Pages: 23-47, ISSN: 1040-6638
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- Citations: 3
Keun HC, Ebbels TMD, Antti H, et al., 2002, Analytical reproducibility in <SUP>1</SUP>H NMR-based metabonomic urinalysis, CHEMICAL RESEARCH IN TOXICOLOGY, Vol: 15, Pages: 1380-1386, ISSN: 0893-228X
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- Citations: 217
Ebbels, T M D, Lindon J C, et al., 2002, Methods for spectral analysis and their applications: spectral replacement, US20010029380 [US2002145425]
Antti H, Bollard ME, Ebbels TM, et al., 2002, Batch statistical processing of H NMR-derived urinary spectral data, J Chemometrics, Vol: 16, Pages: 461-468, ISSN: 0886-9383
Ebbels TMD, Lindon JC, Nicholson JK, 2001, Quantitative investigation of probabilistic spectral processing methods using simulated NMR spectroscopic data, Appl Spectrosc, Vol: 55, Pages: 1214-1224, ISSN: 0003-7028
Bézecourt J, Kneib JP, Soucail G, et al., 1999, Lensed galaxies in Abell 370 -: I.: Modeling the number counts and redshift distribution of background sources, ASTRONOMY & ASTROPHYSICS, Vol: 347, Pages: 21-29, ISSN: 0004-6361
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- Citations: 34
Pelló R, Kneib JP, Le Borgne JF, et al., 1999, Two multiple-imaged <i>z</i>=4.05 galaxies in the cluster-lens Abell 2390, ASTRONOMY & ASTROPHYSICS, Vol: 346, Pages: 359-368, ISSN: 1432-0746
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- Citations: 44
Ebbels T, Ellis R, Kneib JP, et al., 1998, Spectroscopic confirmation of redshifts predicted by gravitational lensing, MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Vol: 295, Pages: 75-91, ISSN: 0035-8711
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- Citations: 40
Ebbels T, 1998, Spectroscopic confirmation of redshifts predicted by gravitational lensing, Monthly Notices of the Royal Astronomical Society, Vol: 295, Pages: 75-75, ISSN: 0035-8711
Ebbels TMD, LeBorgne JF, Pello R, et al., 1996, Identification of a gravitationally lensed z=2.515 star-forming galaxy, MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Vol: 281, Pages: L75-L81, ISSN: 0035-8711
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- Citations: 62
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