Imperial College London
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ProfessorTimothyEbbels

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Biomedical Data Science
 
 
 
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Contact

 

+44 (0)20 7594 3160t.ebbels Website

 
 
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Location

 

315DBurlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Buesen:2017:10.1016/j.yrtph.2017.09.002,
author = {Buesen, R and Chorley, BN and Lima, BDS and Daston, G and Deferme, L and Ebbels, T and Gant, TW and Goetz, A and Greally, J and Gribaldo, L and Hackermueller, J and Hubesch, B and Jennen, D and Johnson, K and Kanno, J and Kauffmann, H-M and Laffont, M and McMullen, P and Meehan, R and Pemberton, M and Perdichizzi, S and Piersma, AH and Sauer, UG and Schmidt, K and Seitz, H and Sumida, K and Tollefsen, KE and Tong, W and Tralau, T and van, Ravenzwaay B and Weber, RJM and Worth, A and Yauk, C and Poole, A},
doi = {10.1016/j.yrtph.2017.09.002},
journal = {Regulatory Toxicology and Pharmacology},
pages = {S3--S13},
title = {Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop},
url = {http://dx.doi.org/10.1016/j.yrtph.2017.09.002},
volume = {91},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Prevailing knowledge gaps in linking specific molecular changes to apical outcomes and methodological uncertainties in the generation, storage, processing, and interpretation of 'omics data limit the application of 'omics technologies in regulatory toxicology. Against this background, the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) convened a workshop Applying 'omics technologies in chemicals risk assessment that is reported herein. Ahead of the workshop, multi-expert teams drafted frameworks on best practices for (i) a Good-Laboratory Practice-like context for collecting, storing and curating 'omics data; (ii) the processing of 'omics data; and (iii) weight-of-evidence approaches for integrating 'omics data. The workshop participants confirmed the relevance of these Frameworks to facilitate the regulatory applicability and use of 'omics data, and the workshop discussions provided input for their further elaboration. Additionally, the key objective (iv) to establish approaches to connect 'omics perturbations to phenotypic alterations was addressed. Generally, it was considered promising to strive to link gene expression changes and pathway perturbations to the phenotype by mapping them to specific adverse outcome pathways. While further work is necessary before gene expression changes can be used to establish safe levels of substance exposure, the ECETOC workshop provided important incentives towards achieving this goal.
AU  - Buesen,R
AU  - Chorley,BN
AU  - Lima,BDS
AU  - Daston,G
AU  - Deferme,L
AU  - Ebbels,T
AU  - Gant,TW
AU  - Goetz,A
AU  - Greally,J
AU  - Gribaldo,L
AU  - Hackermueller,J
AU  - Hubesch,B
AU  - Jennen,D
AU  - Johnson,K
AU  - Kanno,J
AU  - Kauffmann,H-M
AU  - Laffont,M
AU  - McMullen,P
AU  - Meehan,R
AU  - Pemberton,M
AU  - Perdichizzi,S
AU  - Piersma,AH
AU  - Sauer,UG
AU  - Schmidt,K
AU  - Seitz,H
AU  - Sumida,K
AU  - Tollefsen,KE
AU  - Tong,W
AU  - Tralau,T
AU  - van,Ravenzwaay B
AU  - Weber,RJM
AU  - Worth,A
AU  - Yauk,C
AU  - Poole,A
DO  - 10.1016/j.yrtph.2017.09.002
EP  - 13
PY  - 2017///
SN  - 0273-2300
SP  - 3
TI  - Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop
T2  - Regulatory Toxicology and Pharmacology
UR  - http://dx.doi.org/10.1016/j.yrtph.2017.09.002
UR  - http://hdl.handle.net/10044/1/56973
VL  - 91
ER  -
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