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@article{Singh:2020:10.3390/ijms21239185,
author = {Singh, A and Walker, K and Ledesma, Amaro R and Ellis, T},
doi = {10.3390/ijms21239185},
journal = {International Journal of Molecular Sciences},
title = {Engineering bacterial cellulose by synthetic biology},
url = {http://dx.doi.org/10.3390/ijms21239185},
volume = {21},
year = {2020}
}

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TY  - JOUR
AB  - Synthetic biology is an advanced form of genetic manipulation that applies the principles of modularity and engineering design to reprogram cells by changing their DNA. Over the last decade, synthetic biology has begun to be applied to bacteria that naturally produce biomaterials, in order to boost material production, change material properties and to add new functionalities to the resulting material. Recent work has used synthetic biology to engineer several Komagataeibacter strains; bacteria that naturally secrete large amounts of the versatile and promising material bacterial cellulose (BC). In this review, we summarize how genetic engineering, metabolic engineering and now synthetic biology have been used in Komagataeibacter strains to alter BC, improve its production and begin to add new functionalities into this easy-to-grow material. As well as describing the milestone advances, we also look forward to what will come next from engineering bacterial cellulose by synthetic biology.
AU  - Singh,A
AU  - Walker,K
AU  - Ledesma,Amaro R
AU  - Ellis,T
DO  - 10.3390/ijms21239185
PY  - 2020///
SN  - 1422-0067
TI  - Engineering bacterial cellulose by synthetic biology
T2  - International Journal of Molecular Sciences
UR  - http://dx.doi.org/10.3390/ijms21239185
UR  - http://hdl.handle.net/10044/1/85984
VL  - 21
ER  -

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