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@article{Horby:2021:10.1016/S0140-6736(21)00149-5,
author = {Horby, PW and Roddick, A and Spata, E and Staplin, N and Emberson, J and Pessoa-Amorim, G and Brightling, C and Prudon, B and Chadwick, D and Ustianowski, A and Ashish, A and Todd, S and Yates, B and Buttery, R and Scott, S and Maseda, D and Baillie, JK and Buch, M and Chappell, L and Day, J and Faust, SN and Jaki, T and Jeffery, K and Juszczak, E and Lim, WS and Montgomery, A and Mumford, A and Rowan, K and Thwaites, G and Mafham, M and Haynes, R and Landray, MJ and Horby, PW and Landray, MJ and Baillie, JK and Buch, M and Chappell, L and Day, J and Faust, SN and Haynes, R and Jaki, T and Jeffery, K and Juszczak, E and Lim, WS and Mafham, M and Montgomery, A and Mumford, A and Rowan, K and Thwaites, G and Sandercock, P and Darbyshire, J and DeMets, D and Fowler, R and Lalloo, D and Roberts, I and Wittes, J and Horby, P and Landray, MJ and Haynes, R and Fletcher, L and Barton, J and Basoglu, A and Brown, R and Brudlo, W and Denis, E and Howard, S and McChlery, G and Taylor, K and Cui, },
doi = {10.1016/S0140-6736(21)00149-5},
journal = {The Lancet},
pages = {605--612},
title = {Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial},
url = {http://dx.doi.org/10.1016/S0140-6736(21)00149-5},
volume = {397},
year = {2021}
}

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TY  - JOUR
AB  - BackgroundAzithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.MethodsIn this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospital with COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients were randomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once per day by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatment groups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment and were twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants and local study staff were not masked to the allocated treatment, but all others involved in the trial were masked to the outcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.FindingsBetween April 7 and Nov 27, 2020, of 16442 patients enrolled in the RECOVERY trial, 9433 (57%) were eligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was 65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomly allocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall, 561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days (rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No
AU  - Horby,PW
AU  - Roddick,A
AU  - Spata,E
AU  - Staplin,N
AU  - Emberson,J
AU  - Pessoa-Amorim,G
AU  - Brightling,C
AU  - Prudon,B
AU  - Chadwick,D
AU  - Ustianowski,A
AU  - Ashish,A
AU  - Todd,S
AU  - Yates,B
AU  - Buttery,R
AU  - Scott,S
AU  - Maseda,D
AU  - Baillie,JK
AU  - Buch,M
AU  - Chappell,L
AU  - Day,J
AU  - Faust,SN
AU  - Jaki,T
AU  - Jeffery,K
AU  - Juszczak,E
AU  - Lim,WS
AU  - Montgomery,A
AU  - Mumford,A
AU  - Rowan,K
AU  - Thwaites,G
AU  - Mafham,M
AU  - Haynes,R
AU  - Landray,MJ
AU  - Horby,PW
AU  - Landray,MJ
AU  - Baillie,JK
AU  - Buch,M
AU  - Chappell,L
AU  - Day,J
AU  - Faust,SN
AU  - Haynes,R
AU  - Jaki,T
AU  - Jeffery,K
AU  - Juszczak,E
AU  - Lim,WS
AU  - Mafham,M
AU  - Montgomery,A
AU  - Mumford,A
AU  - Rowan,K
AU  - Thwaites,G
AU  - Sandercock,P
AU  - Darbyshire,J
AU  - DeMets,D
AU  - Fowler,R
AU  - Lalloo,D
AU  - Roberts,I
AU  - Wittes,J
AU  - Horby,P
AU  - Landray,MJ
AU  - Haynes,R
AU  - Fletcher,L
AU  - Barton,J
AU  - Basoglu,A
AU  - Brown,R
AU  - Brudlo,W
AU  - Denis,E
AU  - Howard,S
AU  - McChlery,G
AU  - Taylor,K
AU  - Cui,G
AU  - Goodenough,B
AU  - King,A
AU  - Lay,M
AU  - Murray,D
AU  - Stevens,W
AU  - Wallendszus,K
AU  - Welsh,R
AU  - Crichton,C
AU  - Davies,J
AU  - Goldacre,R
AU  - Harper,C
AU  - Knight,F
AU  - Latham-Mollart,J
AU  - Mafham,M
AU  - Nunn,M
AU  - Salih,H
AU  - Welch,J
AU  - Campbell,M
AU  - Pessoa-Amorim,G
AU  - Peto,L
AU  - Roddick,A
AU  - Knott,C
AU  - Wiles,J
AU  - Bell,JL
AU  - Emberson,J
AU  - Juszczak,E
AU  - Linsell,L
AU  - Spata,E
AU  - Staplin,N
AU  - Bagley,G
AU  - Cameron,S
AU  - Chamberlain,S
AU  - Farrell,B
AU  - Freeman,H
AU  - Kennedy,A
AU  - Whitehouse,A
AU  - Wilkinson,S
AU  - Wood,C
AU  - Reith,C
AU  - Davies,K
AU  - Halls,H
AU  - Holland,L
AU  - Wilson,K
AU  - Howie,L
AU  - Lunn,M
AU  - Rodgers,P
AU  - Barnard,A
AU  - Beety,J
AU  - Birch,C
AU  - Brend,M
AU  - Chambers,E
AU  - Chappell,L
AU  - Crawshaw,S
AU  - Drake,C
AU  - Duckles-Leech,H
AU  - Graham,J
AU  - Harman,T
AU  - Harper,H
AU  - Lock,S
AU  - Lomme,K
AU  - McMillan,N
AU  - Nickson,I
AU  - Ohia,U
AU  - OKell,E
AU  - Poustie,V
AU  - Sam,S
AU  - Sharratt,P
AU  - Sheffield,J
AU  - Slade,H
AU  - Hoff,WV
AU  - Walker,S
AU  - Williamson,J
AU  - De,Soyza A
AU  - Dimitri,P
AU  - Faust,SN
AU  - Lemoine,N
AU  - Minton,J
AU  - Gilmour,K
AU  - Pearson,K
AU  - Armah,C
AU  - Campbell,D
AU  - Cate,H
AU  - Priest,A
AU  - Thomas,E
AU  - Usher,R
AU  - Johnson,G
AU  - Logan,M
AU  - Pratt,S
AU  - Price,A
AU  - Shirley,K
AU  - Walton,E
AU  - Williams,P
AU  - Yelnoorkar,F
AU  - Hanson,J
AU  - Membrey,H
AU  - Gill,L
AU  - Oliver,A
AU  - Das,S
AU  - Murphy,S
AU  - Sutu,M
AU  - Collins,J
AU  - Monaghan,H
AU  - Unsworth,A
AU  - Beddows,S
AU  - Williams,KB
AU  - Dowling,S
AU  - Gibbons,K
AU  - Pine,K
AU  - Asghar,A
AU  - Aubrey,P
AU  - Jewell,DB
AU  - Donaldson,K
AU  - Skinner,T
AU  - Luo,J
AU  - Mguni,N
AU  - Muzengi,N
AU  - Pleass,R
AU  - Wayman,E
AU  - Coe,A
AU  - Hicks,J
AU  - Hough,M
AU  - Levett
DO  - 10.1016/S0140-6736(21)00149-5
EP  - 612
PY  - 2021///
SN  - 0140-6736
SP  - 605
TI  - Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
T2  - The Lancet
UR  - http://dx.doi.org/10.1016/S0140-6736(21)00149-5
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000620934000025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S0140673621001495?via%3Dihub
UR  - http://hdl.handle.net/10044/1/86993
VL  - 397
ER  -

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