Imperial College London

Dr Theoni K. Georgiou

Faculty of EngineeringDepartment of Materials

Reader in Polymer Chemistry
 
 
 
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Contact

 

t.georgiou Website

 
 
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Location

 

RSM 1.05Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
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66 results found

Constantinou A, Marie-Sainte U, Peng L, Carroll D, McGilvery C, Dunlop I, Georgiou Tet al., 2019, Effect of block copolymer architecture and composition on gold nanoparticle fabrication, Polymer Chemistry, Vol: 10, Pages: 4632-4642, ISSN: 1759-9954

Gold nanoparticles (AuNPs) have many biomedical applications. Their size is a crucial parameter, as it affects cellular uptake. Here, we investigate how the formation of AuNPs is affected by the composition and architecture (AB, BAB and ABA) of the copolymers, which were used as templates for the fabrication of AuNPs.

Journal article

Mohammed AA, Aviles Milan J, Li S, Chung JJ, Stevens MM, Georgiou TK, Jones JRet al., 2019, Open vessel free radical photopolymerization of double network gels for biomaterial applications using glucose oxidase, Journal of Materials Chemistry B, Vol: 7, Pages: 4030-4039, ISSN: 2050-750X

Polymerization of certain gels in the presence of oxygen can lead to hindered reaction rates and low conversion rates, limiting the use of open vessel polymerization and material synthesis. Here, the oxido-reductase enzyme glucose oxidase (GOx) was used to enable open vessel free radical photopolymerization (FRP) of neutral polyacrylamide (PAAm), and polyelectrolyte poly(2-acrylamido-2-methyl-1-propanesulfonic acid) (PAMPS) under ambient conditions. GOx successfully blocks the inhibition pathways created by O2 in FRP, dramatically increasing the polymer conversion rate for both polymers. In the presence of GOx, PAAm and PAMPS achieved conversion of 78% and 100% respectively at a photoinitiator (PI) concentration of 0.05 wt% with GOx, compared to 0% without GOx at the same PI concentration. Cytotoxicity studies of these polymers show high cell viability after GOx is denatured. Double network hydrogels (DNHGs) were successfully produced using the polymers and use of GOx improved compressive fracture stress by a factor of ten. Vinyl functionalized silica nanoparticles (VSNPs) were used as cross linkers of the first network to further enhance the mechanical properties.

Journal article

Constantinou A, Sam-Soon N, Carroll D, Georgiou Tet al., 2018, Thermoresponsive tetrablock terpolymers: effect of architecture and composition on Gelling behavior, Macromolecules, Vol: 51, Pages: 7019-7031, ISSN: 0024-9297

Thermoresponsive gels are an exciting class of materials with many bioapplications, like tissue engineering and drug delivery, but they are also used in formulation industry and 3-D printing. For these applications to be feasible, the gelation temperature must be tailored. Here, it is reported how the gelation temperature is affected and can be tailored by varying the architecture of tetrablock terpolymers. Specifically, 15 copolymers based on penta(ethylene glycol) methyl ether methacrylate (PEGMA, A block), n-butyl methacrylate (BuMA, B block), and the thermoresponsive 2-(dimethylamino)ethyl methacrylate (DMAEMA, C block) were synthesized using group transfer polymerization. Nine tetrablock copolymers of varying architectures, and one triblock copolymer for comparison, with constant molar mass and composition were fabricated. Specifically, the polymers that were investigated are (i) three polymers that contain two A blocks (ABCA, ABAC, and ACAB), (ii) three polymers that contain two B blocks (BACB, BABC, and ABCB), (iii) three polymers that contain two C blocks (CABC, CACB, and ACBC), and (iv) one ABC triblock terpolymer that was synthesized as the control polymer. Then, the five more promising architectures were chosen, and five more polymers with a slightly different composition were synthesized and characterized. Interestingly, it was demonstrated that the block position (architecture) has a significant effect on self-assembly (micelle formation), cloud point, and the rheological and gelling properties of the polymers with two of the tetrablocks showing promise as injectable gels. Specifically, the ACBC terpolymer with 20–30–50 w/w % PEGMA–BuMA–DMAEMA formed gels at at lower concentration but at higher temperatures than the ABC triblock copolymer that was synthesized as a control. On the other hand, the BABC terpolymer with 30–35–45 w/w % PEGMA–BuMA–DMAEMA formed gels at the same concentrations as the ABC triblock

Journal article

Carroll D, Constantinou A, Stingelin N, Georgiou Tet al., 2018, Scalable syntheses of well-defined pentadecablock bipolymer and quintopolymer, Polymer Chemistry, Vol: 9, Pages: 3450-3454, ISSN: 1759-9954

The one-pot syntheses of two pentadeca-(15)-block methacrylate-based amphiphilic copolymers, specifically a bipolymer (AB)7A and a quintopolymer (ABCDE)3, are being reported using a fast and easy to scale up procedure that does not require any intermediate purification steps. Both syntheses were carried out using sequential group transfer polymerisation (GTP) and took under 3.5 h. Amino-containing (DMAEMA, DEAEMA), ether (THFMA, MEGMA) and alkyl (EtMA) methacrylates were used to produce the multiblock copolymers with a final Đ < 1.3.

Journal article

Ellis T, Chiappi M, García-Trenco A, Al-Ejji M, Sarkar S, Georgiou TK, Shaffer MSP, Tetley TD, Schwander S, Ryan MP, Porter AEet al., 2018, Multimetallic microparticles increase the potency of rifampicin against intracellular mycobacterium tuberculosis, ACS Nano, Vol: 12, Pages: 5228-5240, ISSN: 1936-0851

Mycobacterium tuberculosis ( M.tb) has the extraordinary ability to adapt to the administration of antibiotics through the development of resistance mechanisms. By rapidly exporting drugs from within the cytosol, these pathogenic bacteria diminish antibiotic potency and drive the presentation of drug-tolerant tuberculosis (TB). The membrane integrity of M.tb is pivotal in retaining these drug-resistant traits. Silver (Ag) and zinc oxide (ZnO) nanoparticles (NPs) are established antimicrobial agents that effectively compromise membrane stability, giving rise to increased bacterial permeability to antibiotics. In this work, biodegradable multimetallic microparticles (MMPs), containing Ag NPs and ZnO NPs, were developed for use in pulmonary delivery of antituberculous drugs to the endosomal system of M.tb-infected macrophages. Efficient uptake of MMPs by M.tb-infected THP1 cells was demonstrated using an in vitro macrophage infection model, with direct interaction between MMPs and M.tb visualized with the use of electron FIB-SEM tomography. The release of Ag NPs and ZnO NPs within the macrophage endosomal system increased the potency of the model antibiotic rifampicin by as much as 76%, realized through an increase in membrane disorder of intracellular M.tb. MMPs were effective at independently driving membrane destruction of extracellular bacilli located at the exterior face of THP1 macrophages. This MMP system presents as an effective drug delivery vehicle that could be used for the transport of antituberculous drugs such as rifampicin to infected alveolar macrophages, while increasing drug potency. By increasing M.tb membrane permeability, such a system may prove effectual in improving treatment of drug-susceptible TB in addition to M.tb strains considered drug-resistant.

Journal article

Khutoryanskiy VV, Georgiou TK, 2018, Temperature-Responsive Polymers Chemistry, Properties, and Applications, Publisher: John Wiley & Sons, ISBN: 9781119157809

This important resource: Offers an important synthesis of the current research on temperature- responsive polymers Covers the chemistry, the synthetic approaches for presentation and the physiochemical method of temperature- responsive ...

Book

Lu B, Tarn MD, Pamme N, Georgiou TKet al., 2017, Fabrication of Tailorable pH Responsive Cationic Amphiphilic Microgels on a Microfluidic Device for Drug Release, Journal of Polymer Science Part A: Polymer Chemistry, Vol: 56, Pages: 59-66, ISSN: 0887-624X

Cationic, amphiphilic microgels of differing compositions based on hydrophilic, pH, and thermoresponsive 2-(dimethylamino)ethyl methacrylate (DMAEMA) and hydrophobic, nonionic n-butyl acrylate (BuA) are synthesized using a lab-on-a-chip device. Hydrophobic oil-in-water (o/w) droplets are generated via a microfluidic platform, with the dispersed (droplet) phase containing the DMAEMA and BuA, alongside the hydrophobic cross-linker, ethylene glycol dimethacrylate, and a free radical initiator in an organic solvent. Finally, the hydrophobic droplets are photopolymerized via a UV light source as they traverse the microfluidic channel to produce the cationic amphiphilic microgels. This platform enables the rapid, automated, and in situ production of amphiphilic microgels, which do not match the core-shell structure of conventionally prepared microgels but are instead based on random amphiphilic copolymers of DMAEMA and BuA between the hydrophobic cross-links. The microgels are characterized in terms of their swelling and encapsulation abilities, which are found to be influenced by both the pH response and the hydrophobic content of the microgels.

Journal article

Luongo G, Perez JE, Kosel J, Georgiou TK, Regoutz A, Payne DJ, Stevens MM, Porter AE, Dunlop IEet al., 2017, Scalable high-affinity stabilization of magnetic iron oxide nanostructures by a biocompatible antifouling homopolymer, ACS Applied Materials and Interfaces, Vol: 9, Pages: 40059-40069, ISSN: 1944-8244

Iron oxide nanostructures have been widely developed for biomedical applications, due to their magnetic properties and biocompatibility. In clinical application, the stabilization of these nanostructures against aggregation and non-specific interactions is typically achieved using weakly anchored polysaccharides, with better-defined and more strongly anchored synthetic polymers not commercially adopted due to complexity of synthesis and use. Here, we show for the first time stabilization and biocompatibilization of iron oxide nanoparticles by a synthetic homopolymer with strong surface anchoring and a history of clinical use in other applications, poly(2-methacryloyloxyethy phosphorylcholine) (poly(MPC)). For the commercially important case of spherical particles, binding of poly(MPC) to iron oxide surfaces and highly effective individualization of magnetite nanoparticles (20 nm) are demonstrated. Next-generation high-aspect ratio nanowires (both magnetite/maghemite and core-shell iron/iron oxide) are furthermore stabilized by poly(MPC)-coating, with nanowire cytotoxicity at large concentrations significantly reduced. The synthesis approach is exploited to incorporate functionality into the poly(MPC) chain is demonstrated by random copolymerization with an alkyne-containing monomer for click-chemistry. Taking these results together, poly(MPC) homopolymers and random copolymers offer a significant improvement over current iron oxide nanoformulations, combining straightforward synthesis, strong surface-anchoring and well-defined molecular weight.

Journal article

Chung JJ, Sum BST, Li S, Stevens MM, Georgiou TK, Jones JRet al., 2017, Effect of comonomers on physical properties and cell attachment to silica-methacrylate/acrylate hybrids for bone substitution, Macromolecular Rapid Communications, Vol: 38, ISSN: 1022-1336

Hybrids with a silica network covalently bonded to a polymer are promising materials for bone repair. Previous work on synthesizing methyl methacrylate (MMA) based copolymers by reversible addition‐fragmentation chain transfer (RAFT) polymerization gives high tailorability of mechanical properties since sophisticated polymer structures can be designed. However, more flexible hybrids would be beneficial. Here, n‐butyl methacrylate (BMA) and methyl acrylate (MA) based hybrids are produced. Unlike MMA, BMA and MA hybrids do not show plastic deformation, and BMA hybrid has strain to failure of 33%. Although the new hybrids are more flexible, preosteoblast cells do not adhere on their surfaces, due to higher hydrophobicity and lower stiffness. Comonomer choice is crucial for bone regenerative hybrids.

Journal article

Chung JJ, Fujita Y, Li S, Stevens M, Kasuga T, Georgiou T, Jones JRet al., 2017, Biodegradable inorganic-organic hybrids of methacrylate star polymers for bone regeneration, Acta Biomaterialia, Vol: 54, Pages: 411-418, ISSN: 1878-7568

Hybrids that are molecular scale co-networks of organic and inorganic components are promising biomaterials, improving the brittleness of bioactive glass and the strength of polymers. Methacrylate polymers have high potential as the organic source for hybrids since they can be produced, through controlled polymerization, with sophisticated polymer architectures that can bond to silicate networks. Previous studies showed the mechanical properties of hybrids can be modified by polymer architecture and molar mass (MM). However, biodegradability is critical if hybrids are to be used as tissue engineering scaffolds, since the templates must be remodelled by host tissue. Degradation by-products have to either completely biodegrade or be excreted by the kidneys. Enzyme, or bio-degradation is preferred to hydrolysis by water uptake as it is expected to give a more controlled degradation rate. Here, branched and star shaped poly(methyl methacrylate-co-3-(trimethoxysilyl)propyl methacrylate) (poly(MMA-co-TMSPMA)) were synthesized with disulphide based dimethacrylate (DSDMA) as a biodegradable branching agent. Biodegradability was confirmed by exposing the copolymers to glutathione, a tripeptide which is known to cleave disulphide bonds. Cleaved parts of the star polymer from the hybrid system were detected after 2 weeks of immersion in glutathione solution, and MM was under threshold of kidney filtration. The presence of the branching agent did not reduce the mechanical properties of the hybrids and bone progenitor cells attached on the hybrids in vitro. Incorporation of the DSDMA branching agent has opened more possibilities to design biodegradable methacrylate polymer based hybrids for regenerative medicine.Statement of significanceBioactive glasses can regenerate bone but are brittle. Hybrids can overcome this problem as intimate interactions between glass and polymer creates synergetic properties. Implants have previously been made with synthetic polymers that degrade by

Journal article

Constantinou A, Zhao H, McGilvery C, Porter A, Georgiou Tet al., 2017, A comprehensive systematic study on thermoresponsive gels: beyond the common architectures of linear terpolymers, Polymers, Vol: 9, ISSN: 2073-4360

In this study, seven thermoresponsive methacrylate terpolymers with the same molar mass (MM) and composition but various architectures were successfully synthesized using group transfer polymerization (GTP). These terpolymers were based on tri(ethylene glycol) methyl ether methacrylate (TEGMA, A unit), n-butyl methacrylate (BuMA, B unit), and 2-(dimethylamino)ethyl methacrylate (DMAEMA, C unit). Along with the more common ABC, ACB, BAC, and statistical architectures, three diblock terpolymers were also synthesized and investigated for the first time, namely (AB)C, A(BC), and B(AC); where the units in the brackets are randomly copolymerized. Two BC diblock copolymers were also synthesized for comparison. Their hydrodynamic diameters and their effective pKas were determined by dynamic light scattering (DLS) and hydrogen ion titrations, respectively. The self-assembly behavior of the copolymers was also visualized by transmission electron microscopy (TEM). Both dilute and concentrated aqueous copolymer solutions were extensively studied by visual tests and their cloud points (CP) and gel points were determined. It is proven that the aqueous solution properties of the copolymers, with specific interest in their thermoresponsive properties, are influenced by the architecture, with the ABC and A(BC) ones to show clear sol-gel transition.

Journal article

Constantinou AP, Zhao H, McGilvery CM, Porter AE, Georgiou TKet al., 2017, A Comprehensive Systematic Study on Thermoresponsive Gels: Beyond the Common Architectures of Linear Terpolymers, Nanomaterials, Vol: 9, ISSN: 2079-4991

In this study, seven thermoresponsive methacrylate terpolymers with the same molar mass (MM) and composition but various architectures were successfully synthesized using group transfer polymerization (GTP). These terpolymers were based on tri(ethylene glycol) methyl ether methacrylate (TEGMA, A unit), n-butyl methacrylate (BuMA, B unit), and 2-(dimethylamino)ethyl methacrylate (DMAEMA, C unit). Along with the more common ABC, ACB, BAC, and statistical architectures, three diblock terpolymers were also synthesized and investigated for the first time, namely (AB)C, A(BC), and B(AC); where the units in the brackets are randomly copolymerized. Two BC diblock copolymers were also synthesized for comparison. Their hydrodynamic diameters and their effective pKas were determined by dynamic light scattering (DLS) and hydrogen ion titrations, respectively. The self-assembly behavior of the copolymers was also visualized by transmission electron microscopy (TEM). Both dilute and concentrated aqueous copolymer solutions were extensively studied by visual tests and their cloud points (CP) and gel points were determined. It is proven that the aqueous solution properties of the copolymers, with specific interest in their thermoresponsive properties, are influenced by the architecture, with the ABC and A(BC) ones to show clear sol-gel transition.

Journal article

Lu B, Tarn MD, Pamme N, Georgiou TKet al., 2016, Microfluidic fabrication of novel pH-responsive amphiphilic microgel for drug delivery, The 20th International Conference of Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Pages: 729-730

Amphiphilic, pH-responsive microgels for drug delivery were fabricated by on-chip photopolymerisation of precursor droplets containing hydrophilic 2-(dimethylamino)ethyl methacrylate (DMAEMA) and hydrophobic n-butyl acrylate (BuA) monomers enabling efficient polymerisation and excellent control of size, crosslinking density and hydrophobic/hydrophilic ratio of the microgels.

Conference paper

Chung J, Li S, Stevens MM, Georgiou T, Jones JRet al., 2016, Tailoring mechanical properties of sol-gel hybrids for bone regeneration through polymer structure, Chemistry of Materials, Vol: 28, Pages: 6127-6135, ISSN: 1520-5002

Bioglass® was the first synthetic biomaterial that formed a chemical bond to bone. Although bioactive glassscaffolds can mimic bone’s porous structure, they are brittle. Sol-gel derived hybrids could overcome this problem becausetheir nanoscale co-networks of silica and organic polymer have the potential to provide unique physical propertiesand controlled homogenous biodegradation. Copolymers of methyl methacrylate (MMA) and 3-(trimethoxysilyl)propylmethacrylate (TMSPMA) has been used as an organic source for hybrids to take advantage of its self-hardening property.However, the effect of well-defined poly(MMA-co-TMSPMA) architecture in the hybrid system has not been investigated.Here, linear, randomly branched and star shaped methacrylate based copolymers were synthesized via reversible addition-fragmentationchain transfer (RAFT) polymerization method. These copolymers were then used to fabricate hybrids.The 3-D polymer structure had a significant effect on mechanical properties, providing higher strain to failure whilemaintaining a compressive strength similar to sol-gel glass. Star copolymer-SiO2 hybrids had a modulus of toughness 9.6fold greater, and Young’s modulus 4.5 fold lower than a sol-gel derived bioactive glass. During in vitro cell culture,MC3T3-E1 osteoblast precursor cells adhered on the surface regardless of the polymer structure. Introducing star polymersto inorganic-organic hybrids opens up possibilities for the fine-tuning physical properties of bone scaffold materials

Journal article

Lu B, Tarn MD, Pamme N, Georgiou TKet al., 2016, Microfluidically fabricated pH-responsive anionic amphiphilic microgels for drug release, Journal of Materials Chemistry B, Vol: 4, Pages: 3086-3093, ISSN: 2050-7518

Amphiphilic microgels of different composition based on the hydrophilic, pH-responsive acrylic acid (AA) and the hydrophobic, non-ionic n-butyl acrylate (BuA) were synthesised using a lab-on-a-chip device. Hydrophobic droplets were generated via a microfluidic platform that contained a protected form of AA, BuA, the hydrophobic crosslinker, ethylene glycol dimethacrylate (EGDMA), and a free radical initiator in an organic solvent. These hydrophobic droplets were photopolymerised within the microfluidic channels and subsequently hydrolysed, enabling an integrated platform for the rapid, automated, and in situ production of anionic amphiphilic microgels. The amphiphilic microgels did not feature the conventional core–shell structure but were instead based on random amphiphilic copolymers of AA and BuA and hydrophobic crosslinks. Due to their amphiphilic nature they were able to encapsulate and deliver both hydrophobic and hydrophilic moieties. The model drug delivery and the swelling ability of the microgels were influenced by the pH of the surrounding aqueous solution and the hydrophobic content of the microgels.

Journal article

D'Elia E, Eslava S, Miranda M, Georgiou TK, Saiz Eet al., 2016, Autonomous self-healing structural composites with bio-inspired design, Scientific Reports, Vol: 6, ISSN: 2045-2322

Strong and tough natural composites such as bone, silk or nacre are often built from stiff blocks boundtogether using thin interfacial soft layers that can also provide sacrificial bonds for self-repair. Herewe show that it is possible exploit this design in order to create self-healing structural composites byusing thin supramolecular polymer interfaces between ceramic blocks. We have built model brick-andmortarstructures with ceramic contents above 95 vol% that exhibit strengths of the order of MPa(three orders of magnitude higher than the interfacial polymer) and fracture energies that are twoorders of magnitude higher than those of the glass bricks. More importantly, these properties can befully recovered after fracture without using external stimuli or delivering healing agents. This approachdemonstrates a very promising route towards the design of strong, ideal self-healing materials able toself-repair repeatedly without degradation or external stimuli.

Journal article

Georgiou T, Constantinou A, 2016, Thermoresponsive Gels based on ABC Triblock Copolymers: Effect of the Length of the PEG Side Group, Polymer Chemistry, Vol: 7, Pages: 2045-2056, ISSN: 1759-9962

In this study, one statistical and nine well-defined ABC triblock thermoresponsive terpolymers were synthesised via group transfer polymerisation (GTP). The A, B, and C blocks were based on poly(ethylene glycol) (PEG) based methacrylate , n-butyl methacrylate (BuMA), and 2-(dimethylamino)ethyl methacrylate (DMAEMA), respectively. The length of the PEG side group was varied. Specifically, three different PEG based monomers were used; methoxy di-, penta-, and nona(ethylene glycol) methacrylate (DEGMA, PEGMA, and NEGMA, respectively). Along with the length of PEG side group, the composition of the terpolymers was also systematically varied in order to investigate the effect of both these parameters on the thermoresponsive behaviour of the polymers. The molar mass (MM) and the architecture were kept the same. Their hydrodynamic diameters, the effective pKas, and the cloud points of aqueous copolymer solutions were determined by dynamic light scattering (DLS), potentiometric titrations, and visual tests, respectively. Micelle formation was observed for all the copolymers and the pKas were influenced by the hydrophobic content but not by the PEG side length. On the other hand both the composition and the PEG side chain length affected the cloud points and the sol-gel transition. In summary, it was demonstrated the sol-gel transition can be tailored by varying both the PEG length as well as the composition of the polymers.

Journal article

Constantinou A, Georgiou, 2016, Tuning the Gelation of Thermoresponsive Gels, European Polymer Journal, Vol: 78, Pages: 366-375, ISSN: 1873-1945

Thermoresponsive gels are exciting polymeric materials with many biomedical applicationsin medical devices, drug delivery, tissue engineering and bio-printing. Also, they have greatpotential to be used in 3-D printing and thus in the fabrication of many different devices andmaterials. As it is crucial for the application of these gels to be able to control and tailor thegelation temperature and concentration this was the main focus and point of discussion of thisfeature article. Thus, it is discussed in detail how by varying the molar mass, composition,stereochemistry and architecture the thermoresponsive properties of these gels are altered.

Journal article

Chung JJ, Jones JR, Georgiou T, 2015, Towards Hybrid Materials: Group Transfer Polymerization of 3-(Trimethoxylsilyl)propyl Methacrylate, Macromolecular Rapid Communications, Vol: 36, Pages: 1806-1809, ISSN: 1521-3927

In this study the Group Transfer Polymerization (GTP) of the functional monomer 3-(trimethoxylsilyl)propyl methacrylate (TMSPMA) is reported to produce polymers of different architectures and topologies. TMSPMA was successfully polymerized and copolymerized with GTP to produce well-defined (co)polymers that can be used to fabricate functional hybrid materials like hydrogels and films.

Journal article

Chung JJ, Jones JR, Georgiou TK, 2015, Toward Hybrid Materials: Group Transfer Polymerization of 3-(Trimethoxysilyl)propyl Methacrylate, Macromolecular Rapid Communications, Vol: 36, Pages: 1806-1809, ISSN: 1521-3927

In this study, the group transfer polymerization (GTP) of the functionalmonomer 3-(trimethoxysilyl)propyl methacrylate (TMSPMA)is reported to produce polymers of different architectures andtopologies. TMSPMA is successfully polymerized and copolymerizedwith GTP to produce well-defi ned (co)polymers that canbe used to fabricate functional hybrid materials like hydrogels andfi lms.

Journal article

Ghasdian N, Buzza DMA, Fletcher PDI, Georgiou TKet al., 2015, ABC Triblock Copolymer Micelles: Spherical Versus Worm-Like Micelles Depending on the Preparation Method, MACROMOLECULAR RAPID COMMUNICATIONS, Vol: 36, Pages: 528-532, ISSN: 1022-1336

Journal article

Fleischli FD, Ghasdian N, Georgiou TK, Stingelin Net al., 2015, Tailoring the optical properties of poly(3-hexylthiophene) by emulsion processing using polymeric macrosurfactants, Journal of Materials Chemistry C, Vol: 3, Pages: 2065-2071, ISSN: 2050-7534

Journal article

Lu B, Tarn MD, Pamme N, Georgiou TKet al., 2015, Tailoring pH-responsive acrylic acid microgels with hydrophobic crosslinks for drug release, JOURNAL OF MATERIALS CHEMISTRY B, Vol: 3, Pages: 4524-4529, ISSN: 2050-750X

Journal article

Lu B, Tarn MD, Pamme N, Georgiou TKet al., 2015, Novel amphiphilic microgels fabricated via on-chip polymerisation, Pages: 1044-1046

© 15CBMS-0001. We report the on-chip polymerisation of hydrophobic microgels from precursor droplets, and their downstream synthesis to pH-responsive amphiphilic microgels for drug delivery. This elegant platform offers superior control over microgel properties, including size, crosslinking density and hydrophobic/hydrophilic properties. The encapsulation and release of hydrophilic (Trypan Blue) and hydrophobic (Sudan Red) dyes based on the microgel shrinking/swelling properties was also studied.

Conference paper

Georgiou TK, 2014, Star polymers for gene delivery, POLYMER INTERNATIONAL, Vol: 63, Pages: 1130-1133, ISSN: 0959-8103

Journal article

Lu B, Tarn MD, Pamme N, Georgiou TKet al., 2014, Amphiphilic microgels from polymerisation of hydrophobic droplets - Novel microgels fabricated on-chip, Pages: 1199-1201

© 14CBMS. We report the synthesis of microgels for drug delivery via on-chip droplet generation and downstream photo-polymerization which affords control over hydrophobicity/hydrophilicity and enables the synthesis of amphiphilic microgels from hydrophobic droplets. The amphiphilic microgels were found to be effective for encapsulation and release of a hydrophobic dye (Sudan red) as an analog of a drug molecule.

Conference paper

Ghasdian N, Ward MA, Georgiou TK, 2014, Well-defined "clickable'' copolymers prepared via one-pot synthesis, CHEMICAL COMMUNICATIONS, Vol: 50, Pages: 7114-7116, ISSN: 1359-7345

Journal article

Buzza DMA, Fletcher PDI, Georgiou TK, Ghasdian Net al., 2013, Water-in-Water Emulsions Based on Incompatible Polymers and Stabilized by Triblock Copolymers-Templated Polymersomes, LANGMUIR, Vol: 29, Pages: 14804-14814, ISSN: 0743-7463

Journal article

Ward MA, Georgiou TK, 2013, Thermoresponsive gels based on ABA triblock copolymers: Does the asymmetry matter?, JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, Vol: 51, Pages: 2850-2859, ISSN: 0887-624X

Journal article

Ghasdian N, Church E, Cottam AP, Hornsby K, Leung M-Y, Georgiou TKet al., 2013, Novel "core-first" star-based quasi-model amphiphilic polymer networks, RSC ADVANCES, Vol: 3, Pages: 19070-19080, ISSN: 2046-2069

Journal article

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