Imperial College London
Alternate

Professor Theoni K. Georgiou

Faculty of Engineering, Department of Materials

Professor in Polymer Chemistry
 
 
 
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Contact

 

t.georgiou Website

 
 
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Location

 

RSM 1.05Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mohammed:2019:10.1039/c9tb00658c,
author = {Mohammed, AA and Aviles, Milan J and Li, S and Chung, JJ and Stevens, MM and Georgiou, TK and Jones, JR},
doi = {10.1039/c9tb00658c},
journal = {Journal of Materials Chemistry B},
pages = {4030--4039},
title = {Open vessel free radical photopolymerization of double network gels for biomaterial applications using glucose oxidase},
url = {http://dx.doi.org/10.1039/c9tb00658c},
volume = {7},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Polymerization of certain gels in the presence of oxygen can lead to hindered reaction rates and low conversion rates, limiting the use of open vessel polymerization and material synthesis. Here, the oxido-reductase enzyme glucose oxidase (GOx) was used to enable open vessel free radical photopolymerization (FRP) of neutral polyacrylamide (PAAm), and polyelectrolyte poly(2-acrylamido-2-methyl-1-propanesulfonic acid) (PAMPS) under ambient conditions. GOx successfully blocks the inhibition pathways created by O2 in FRP, dramatically increasing the polymer conversion rate for both polymers. In the presence of GOx, PAAm and PAMPS achieved conversion of 78% and 100% respectively at a photoinitiator (PI) concentration of 0.05 wt% with GOx, compared to 0% without GOx at the same PI concentration. Cytotoxicity studies of these polymers show high cell viability after GOx is denatured. Double network hydrogels (DNHGs) were successfully produced using the polymers and use of GOx improved compressive fracture stress by a factor of ten. Vinyl functionalized silica nanoparticles (VSNPs) were used as cross linkers of the first network to further enhance the mechanical properties.
AU  - Mohammed,AA
AU  - Aviles,Milan J
AU  - Li,S
AU  - Chung,JJ
AU  - Stevens,MM
AU  - Georgiou,TK
AU  - Jones,JR
DO  - 10.1039/c9tb00658c
EP  - 4039
PY  - 2019///
SN  - 2050-750X
SP  - 4030
TI  - Open vessel free radical photopolymerization of double network gels for biomaterial applications using glucose oxidase
T2  - Journal of Materials Chemistry B
UR  - http://dx.doi.org/10.1039/c9tb00658c
UR  - https://pubs.rsc.org/en/content/articlelanding/2019/TB/C9TB00658C#!divAbstract
UR  - http://hdl.handle.net/10044/1/70338
VL  - 7
ER  -
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