Imperial College London
Alternate

Professor Theoni K. Georgiou

Faculty of Engineering, Department of Materials

Professor in Polymer Chemistry
 
 
 
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Contact

 

t.georgiou Website

 
 
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Location

 

RSM 1.05Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Li:2020:10.1039/d0ma00674b,
author = {Li, Volsi A and Tallia, F and Iqbal, H and Georgiou, TK and Jones, JR},
doi = {10.1039/d0ma00674b},
journal = {Materials Advances},
title = {Enzyme degradable star polymethacrylate/silica hybrid inks for 3D printing of tissue scaffolds},
url = {http://dx.doi.org/10.1039/d0ma00674b},
volume = {1},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There is unmet clinical need for scaffolds that can share load with the host tissue while biodegrading under the action of enzymes present at the site of implantation. The aim here was to create the first enzyme cleavable inorganic–organic hybrid “inks” that can be 3D printed as scaffolds for bone regeneration. Inorganic–organic hybrids are co-networks of inorganic and organic components. Although previous hybrids performed well under cyclic loads, there was little control over their degradation. Here we synthesised new hybrids able to degrade in response to endogenous tissue specific metallo proteinases (collagenases) that are involved in natural remodeling of bone. Three well-defined star polymers, of the monomer 3-(trimethoxysilyl)propyl methacrylate (TMSPMA) and of methyl methacrylate (MMA), of different architectures were prepared by RAFT polymerisation. The linear arms were connected together at an enzyme degradable core using a collagenase cleavable peptide sequence (GLY-PRO-LEU-GLY-PRO-LYS) modified with dimethacryloyl groups as a crosslinker for RAFT polymerisation. The effect of polymer architecture, i.e. the position of the TMSPMA groups on the polymers, on bonding between networks, mechanical properties, biodegradation rate and 3D printability, via direct ink writing, was investigated for the first time and was proven to be critical for all three properties. Specifically, hybrids made with star polymers with the TMSPMA close to the core exhibited the best mechanical properties, improved printability and a higher degradation rate.
AU  - Li,Volsi A
AU  - Tallia,F
AU  - Iqbal,H
AU  - Georgiou,TK
AU  - Jones,JR
DO  - 10.1039/d0ma00674b
PY  - 2020///
SN  - 2633-5409
TI  - Enzyme degradable star polymethacrylate/silica hybrid inks for 3D printing of tissue scaffolds
T2  - Materials Advances
UR  - http://dx.doi.org/10.1039/d0ma00674b
UR  - http://hdl.handle.net/10044/1/85849
VL  - 1
ER  -
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