Imperial College London
Alternate

Professor Theoni K. Georgiou

Faculty of Engineering, Department of Materials

Professor in Polymer Chemistry
 
 
 
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Contact

 

t.georgiou Website

 
 
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Location

 

RSM 1.05Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Correia:2023:10.1039/d2py01012g,
author = {Correia, JS and Miron, Barroso S and Hutchings, C and Ottaviani, S and Somuncuolu, B and Castellano, L and Porter, AE and Krell, J and Georgiou, TK},
doi = {10.1039/d2py01012g},
journal = {Polymer Chemistry},
pages = {303--317},
title = {How does the polymer architecture and position of cationic charges affect cell viability?},
url = {http://dx.doi.org/10.1039/d2py01012g},
volume = {14},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Polymer chemistry, composition and molar mass are factors that are known to affect cytotoxicity however the influence of polymer architecture has not been investigated systematically. In this study the influence of the position of the cationic charges along the polymer chain on cytotoxicity was investigated while keeping constant the other polymer characteristics. Specifically, copolymers of various architectures, based on a cationic pH responsive monomer, 2-(dimethylamino)ethyl methacrylate (DMAEMA) and a non-ionic hydrophilic monomer, oligo(ethylene glycol)methyl ether methacrylate (OEGMA) were engineered and their toxicity towards a panel of cell lines investigated. Of the seven different polymer architectures examined, the block-like structures were less cytotoxic than statistical or gradient/tapered architectures. These findings will assist in developing future vectors for nucleic acid delivery.
AU  - Correia,JS
AU  - Miron,Barroso S
AU  - Hutchings,C
AU  - Ottaviani,S
AU  - Somuncuolu,B
AU  - Castellano,L
AU  - Porter,AE
AU  - Krell,J
AU  - Georgiou,TK
DO  - 10.1039/d2py01012g
EP  - 317
PY  - 2023///
SN  - 1759-9954
SP  - 303
TI  - How does the polymer architecture and position of cationic charges affect cell viability?
T2  - Polymer Chemistry
UR  - http://dx.doi.org/10.1039/d2py01012g
UR  - https://pubs.rsc.org/en/Content/ArticleLanding/2022/PY/D2PY01012G
UR  - http://hdl.handle.net/10044/1/102139
VL  - 14
ER  -
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