Overview
Research Interests
My major interest is in elucidating mechanisms of injury in glomerulonephritis. We have used a number of models of induced and autoimmune glomerulonephritis to explore the role of macrophages, antibodies, Fc receptors, complement and other mediators. We have also studied genetic influences on susceptibility to glomerulonephritis and to autoimmunity. We are currently investigating the genes that control macrophage activation and the contribution of these to crescentic glomerulonephritis.
Clinical Research
I have a major interest in how histological features in human renal biopsies can be used to predict outcome and response to treatment. I have organised international collaborative studies to develop consensus classifications of lupus glomerulonephritis, IgA nephropathy and diabetic nephropathy. We are currently studying the predictive value of transcript analysis in biopsies of transplant kidneys.
Guest Lectures
The Pathology of Lupus Nephritis, Highlights in Nephrology Symposium, Utrecht, 2006
Interpretation of renal biopsies in IgA nephropathy, 11th International Symposium on IgA nephropathy, Tokyo, 2006
Atheroembolic and Large Vessel Renal Diseases, 37th Course on Advances in Nephrology and Dialysis, Milan, Italy, 2005
Pathology of The Renal Transplant Biopsy, 6th International Congress of the Nephrology, Urology and Transplantation Society of SAARC countries, Dhaka, Bangladesh, 2005
Crescentic Glomerulonephritis, Indian Society of Nephrology, Cochin, India, 2005
Haemolytic Uraemic Syndrome, Indian Society of Nephrology, Cochin, India, 2005
Pathogenesis and Classification of Kidney Transplant Rejection, 1st International Conference on Recent Advances in Renal Transplantation, Riyadh, Saudi Arabia, 2005
The Role of FcR in Renal Inflammation, American Society of Nephrology, 2005
Immunopathology of HCV-associated MPGN and DD Disease, American Society of Nephrology, 2005
Systemic Lupus Erythematosus, Postgraduate Education Course of the American Society of Nephrology, 2005
Histopathology, Classifcation and prognostic factors in IgA nephropathy, 20th European Congress of Pathology, 2005
IgA nephropathy, EDTA-ERA meeting Istanbul, 2005
Best Practice in the Examination of the Renal Biopsy, EDTA-ERA meeting Istanbul, 2005
Glomerulonephritis: Recent insights into pathogenesis, 3rd ISN Update course in Nephrology, 2004
Relationship between abnormalities in the complement system and MPGN/HUS, American Society of Nephrology, 2004
MPGN2 - lessons from animal models, MPGN Focus Group meeting, Boston, 2004
Complement, apoptosis and glomerulonephritis, 2nd European Nephropathology and Nephrology Workshop, 2004
Lupus nephritis, European Renal Association, 2004
Glomerulonephritis in Factor H Deficient Mice, World Congress of Nephrology, 2003
Crescentic Glomerulonephritis, Egyptian Society of Nephrology, 2003
Interpretation and Clinical Application of the Renal Biopsy, American Society of Nephrology, 2001
Complement Deficiencies Lupus and Apoptosis, Necker Seminars in Nephrology, 2001