Imperial College London


Faculty of MedicineDepartment of Immunology and Inflammation

Emeritus Professor



+44 (0)20 3313 2009t.h.cook




Miss Claudia Rocchi +44 (0)20 3313 2315




9N9Commonwealth BuildingHammersmith Campus





Research Interests

My major interest is in elucidating mechanisms of injury in glomerulonephritis. We have used a number of models of induced and autoimmune glomerulonephritis to explore the role of macrophages, antibodies, Fc receptors, complement and other mediators. We have also studied genetic influences on susceptibility to glomerulonephritis and to autoimmunity. We are currently investigating the genes that control macrophage activation and the contribution of these to crescentic glomerulonephritis.

Clinical Research

I have a major interest in how histological features in human renal biopsies can be used to predict outcome and response to treatment. I have organised international collaborative studies to develop consensus classifications of lupus glomerulonephritis, IgA nephropathy and diabetic nephropathy. We are currently studying the predictive value of transcript analysis in biopsies of transplant kidneys.

Guest Lectures

The Pathology of Lupus Nephritis, Highlights in Nephrology Symposium, Utrecht, 2006

Interpretation of renal biopsies in IgA nephropathy, 11th International Symposium on IgA nephropathy, Tokyo, 2006

Atheroembolic and Large Vessel Renal Diseases, 37th Course on Advances in Nephrology and Dialysis, Milan, Italy, 2005

Pathology of The Renal Transplant Biopsy, 6th International Congress of the Nephrology, Urology and Transplantation Society of SAARC countries, Dhaka, Bangladesh, 2005

Crescentic Glomerulonephritis, Indian Society of Nephrology, Cochin, India, 2005

Haemolytic Uraemic Syndrome, Indian Society of Nephrology, Cochin, India, 2005

Pathogenesis and Classification of Kidney Transplant Rejection, 1st International Conference on Recent Advances in Renal Transplantation, Riyadh, Saudi Arabia, 2005

The Role of FcR in Renal Inflammation, American Society of Nephrology, 2005

Immunopathology of HCV-associated MPGN and DD Disease, American Society of Nephrology, 2005

Systemic Lupus Erythematosus, Postgraduate Education Course of the American Society of Nephrology, 2005

Histopathology, Classifcation and prognostic factors in IgA nephropathy, 20th European Congress of Pathology, 2005

IgA nephropathy, EDTA-ERA meeting Istanbul, 2005

Best Practice in the Examination of the Renal Biopsy, EDTA-ERA meeting Istanbul, 2005

Glomerulonephritis: Recent insights into pathogenesis, 3rd ISN Update course in Nephrology, 2004

Relationship between abnormalities in the complement system and MPGN/HUS, American Society of Nephrology, 2004

MPGN2 - lessons from animal models, MPGN Focus Group meeting, Boston, 2004

Complement, apoptosis and glomerulonephritis, 2nd European Nephropathology and Nephrology Workshop, 2004

Lupus nephritis, European Renal Association, 2004

Glomerulonephritis in Factor H Deficient Mice, World Congress of Nephrology, 2003

Crescentic Glomerulonephritis, Egyptian Society of Nephrology, 2003

Interpretation and Clinical Application of the Renal Biopsy, American Society of Nephrology, 2001

Complement Deficiencies Lupus and Apoptosis, Necker Seminars in Nephrology, 2001