Imperial College London

Professor Trevor Hansel

Faculty of MedicineNational Heart & Lung Institute

Professor of Respiratory Pharmacology
 
 
 
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Contact

 

+44 (0)20 3312 5733t.hansel

 
 
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Location

 

Imperial Clinical Respiratory ReMint WingSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

119 results found

Melo JT, Tunstall T, Pizzichini MMM, Maurici R, Rocha CC, Dal-Pizzol F, Goncalves J, Hansel TT, Thwaites RS, Pizzichini Eet al., 2019, IL-5 Levels in Nasosorption and Sputosorption Correlate with Sputum Eosinophilia in Allergic Asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 199, Pages: 240-243, ISSN: 1073-449X

JOURNAL ARTICLE

Thwaites RS, Coates M, Ito K, Ghazaly M, Feather C, Abdulla F, Tunstall T, Jain P, Cass L, Rapeport G, Hansel TT, Nadel S, Openshaw Pet al., 2018, Reduced Nasal Viral Load and IFN Responses in Infants with Respiratory Syncytial Virus Bronchiolitis and Respiratory Failure, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 198, Pages: 1074-1084, ISSN: 1073-449X

JOURNAL ARTICLE

Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ, Moffatt MF, O'Garra A, Openshaw PJMet al., 2018, Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza, NATURE IMMUNOLOGY, Vol: 19, Pages: 625-+, ISSN: 1529-2908

JOURNAL ARTICLE

Thwaites RS, Gunawardana NC, Broich V, Mann EH, Ahnstrom J, Campbell GA, Lindsley S, Singh N, Tunstall T, Lane DA, Openshaw PJ, Hawrylowicz CM, Hansel TTet al., 2018, Biphasic activation of complement and fibrinolysis during the human nasal allergic response, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 141, Pages: 1892-+, ISSN: 0091-6749

JOURNAL ARTICLE

Cai F, Abreu F, Ding HT, Choy D, Bremer M, Staton T, Erickson R, Peng K, Wang JS, Au-Yeung A, Hansel TT, Bjermer L, Holweg C, Yen K, Matthews JG, Scheerens Het al., 2018, Nasal Biomarkers Characterization In Lebrikizumab Bronchoscopy Study (CLAVIER), American-Academy-of-Allergy-Asthma-and-Immunology / World-Allergy-Organization Joint Congress, Publisher: MOSBY-ELSEVIER, Pages: AB118-AB118, ISSN: 0091-6749

CONFERENCE PAPER

Dhariwal J, Cameron A, Wong E, Trujillo-Torralbo B, Del Rosario A, Bakhsoliani E, Paulsen M, Jackson D, Hansel TT, Edwards M, Cousins D, Walton RP, Johnston SLet al., 2018, Pulmonary Innate Lymphoid Cell Responses During Rhinovirus-Induced Asthma Exacerbations, American-Academy-of-Allergy-Asthma-and-Immunology / World-Allergy-Organization Joint Congress, Publisher: MOSBY-ELSEVIER, Pages: AB195-AB195, ISSN: 0091-6749

CONFERENCE PAPER

Gunawardana NC, Zhao Q, Carayannopoulos LN, Tsai K, Malkov VA, Selverian D, Clarke G, Mant T, Butts BD, Lund K, Hansel TT, Nolte Het al., 2018, The effects of house dust mite sublingual immunotherapy tablet on immunologic biomarkers and nasal allergen challenge symptoms, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 141, Pages: 785-+, ISSN: 0091-6749

JOURNAL ARTICLE

Thwaites RS, Jarvis HC, Singh N, Jha A, Pritchard A, Fan H, Tunstall T, Nanan J, Nadel S, Kon OM, Openshaw PJ, Hansel TTet al., 2018, Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, ISSN: 1940-087X

JOURNAL ARTICLE

Jarvis H, Thwaites RS, Tunstall T, Nanan JN, Tolosa-Wright M, Marwah I, Reuschl AK, Hansel TT, Lalvani A, Kon OMet al., 2017, ISOLATED MEDIASTINAL LYMPH NODE TUBERCULOSIS (IMLNTB) IS CHARACTERISED BY ELEVATION IN SYSTEMIC AND BRONCHIAL IL-12 PATHWAY MEDIATORS COMPARED TO PULMONARY TB, Winter Meeting of the British-Thoracic-Society

POSTER

Dhariwal J, Cameron A, Trujillo-Torralbo M-B, del Rosario A, Bakhsoliani E, Paulsen M, Jackson DJ, Edwards MR, Rana BMJ, Cousins DJ, Hansel TT, Johnston SL, Walton RPet al., 2017, Mucosal Type 2 Innate Lymphoid Cells Are a Key Component of the Allergic Response to Aeroallergens, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 195, Pages: 1586-1596, ISSN: 1073-449X

JOURNAL ARTICLE

Hansel TT, Tunstall T, Trujillo-Torralbo M-B, Shamji B, del-Rosario A, Dhariwal J, Kirk PDW, Stumpf MPH, Koopmann J, Telcian A, Aniscenko J, Gogsadze L, Bakhsoliani E, Stanciu L, Bartlett N, Edwards M, Walton R, Mallia P, Hunt TM, Hunt TL, Hunt DG, Westwick J, Edwards M, Kon OM, Jackson DJ, Johnston SLet al., 2017, A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-gamma and IFN-lambda) and Type 2 Inflammation (IL-5 and IL-13), EBIOMEDICINE, Vol: 19, Pages: 128-138, ISSN: 2352-3964

JOURNAL ARTICLE

Thwaites RS, Ito K, Chingono JMS, Coates M, Jarvis HC, Tunstall T, Anderson-Dring L, Cass L, Rapeport G, Openshaw PJ, Nadel S, Hansel TTet al., 2017, Nasosorption as a Minimally Invasive Sampling Procedure: Mucosal Viral Load and Inflammation in Primary RSV Bronchiolitis, JOURNAL OF INFECTIOUS DISEASES, Vol: 215, Pages: 1240-1244, ISSN: 0022-1899

JOURNAL ARTICLE

Leaker BR, Malkov VA, Mogg R, Ruddy MK, Nicholson GC, Tan AJ, Tribouley C, Chen G, De Lepeleire I, Calder NA, Chung H, Lavender P, Carayannopoulos LN, Hansel TTet al., 2017, The nasal mucosal late allergic reaction to grass pollen involves type 2 inflammation (IL-5 and IL-13), the inflammasome (IL-1b), and complement, MUCOSAL IMMUNOLOGY, Vol: 10, Pages: 408-420, ISSN: 1933-0219

JOURNAL ARTICLE

Pruski P, MacIntyre DA, Lewis HV, Inglese P, Correia GDS, Hansel TT, Bennett PR, Holmes E, Takats Zet al., 2017, Medical Swab Analysis Using Desorption Electrospray Ionization Mass Spectrometry: A Noninvasive Approach for Mucosal Diagnostics, ANALYTICAL CHEMISTRY, Vol: 89, Pages: 1540-1550, ISSN: 0003-2700

JOURNAL ARTICLE

Thwaites RS, Gunawardana NC, Broich VL, Mann EH, Campbell GA, Tunstall T, Lindsley S, Hawrylowicz CM, Openshaw PJM, Hansel TTet al., 2017, Activation of the Complement, Coagulation and Fibrinolysis Pathways after Nasal Allergen Challenge, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB384-AB384, ISSN: 0091-6749

CONFERENCE PAPER

Minshall E, Patel H, Francis N, Hansel TT, Warner JO, Boyle RJ, Fell J, Epstein Jet al., 2017, Local chemokine profiling in eosinophilic esophagitis: The synthetic absorptive matrix test, PEDIATRIC ALLERGY AND IMMUNOLOGY, Vol: 28, Pages: 100-102, ISSN: 0905-6157

JOURNAL ARTICLE

Gunawardana NC, Jain A, Zhao Q, Tsai K, George L, Selverian D, Carayannopoulos LN, Lund K, Clarke G, Mant T, Hansel TT, Nolte Het al., 2017, Biomarkers of 12 SQ House Dust Mite Sublingual Immunotherapy (SLIT)-Tablet Treatment After Nasal Allergen Challenge, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB192-AB192, ISSN: 0091-6749

CONFERENCE PAPER

Abbara A, Mahomed Z, Collin SM, Kon OM, Bushell V, Buell K, Sullivan JAL, Hansel T, Corrah T, Davidson RNet al., 2016, OLDER PATIENTS WITH TUBERCULOSIS HAVE LESS TYPICAL CHANGES ON CHEST RADIOGRAPHS, THORAX, Vol: 71, Pages: A143-A143, ISSN: 0040-6376

JOURNAL ARTICLE

Abbara A, Hardman E, Collin SM, Kon OM, Mahomed Z, Sullivan JAL, Buell K, Hansel T, Corrah T, Davidson RNet al., 2016, THE NATURE AND DURATION OF SYMPTOMS AND TIME TO STARTING TREATMENT COMPARING OLDER WITH YOUNGER PULMONARY TUBERCULOSIS PATIENTS, THORAX, Vol: 71, Pages: A51-A52, ISSN: 0040-6376

JOURNAL ARTICLE

Gunawardana N, Campbell G, Lindsley S, Thwaites R, Mann E, Tunstall T, Openshaw P, Johnston S, Hawrylowicz C, Hansel Tet al., 2016, The effect of vitamin D supplementation on cathelicidin levels, vitamin D receptor (VDR) and E-cadherin expression after nasal allergen challenge in allergic rhinitis, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY-BLACKWELL, Pages: 1666-1666, ISSN: 0954-7894

CONFERENCE PAPER

Batista C, McIntosh M, Hansel T, Donnelly L, Barnes Pet al., 2016, Elevated concentrations of CXCL8 in the nasal mucosal lining fluid of COPD patients as an accessible surrogate measure of bronchial levels, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

CONFERENCE PAPER

Jha A, Dunning J, Tunstall T, Hansel T, Openshaw Pet al., 2016, Asthma patients hospitalized with influenza lack mucosal and systemic type 2 inflammation, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

CONFERENCE PAPER

Poletti D, Iannini V, Casolari P, Contoli M, Papi A, Kirkham P, Hansel TT, Chung KF, Barnes PJ, Pastore A, Pelucchi S, Adcock IM, Caramori Get al., 2016, Nasal inflammation and its response to local glucocorticoid regular treatment in patients with persistent non-allergic rhinitis: a pilot study, JOURNAL OF INFLAMMATION-LONDON, Vol: 13, ISSN: 1476-9255

JOURNAL ARTICLE

Jha A, Progatzky F, Wane M, Thwaites RS, McBrien M, Brimley J, Tunstall T, Shattock RJ, Bugeon L, Openshaw PJM, Dallman MJ, Hansel TTet al., 2016, Human nasal mucosal responses to TLR agonists are mirrored by the zebrafish gill, British Association of Lung Research Summer Congress

Introduction: There are few reliable ways to study respiratory mucosal immune responses to viruses, viral-type toll-like receptor (TLR) agonists and vaccines. To investigate innate immune responses to TLR agonists (TLR3: poly IC/ poly ICLC; TLR7/8: resiquimod), we compared the effects on human nasal mucosa and zebrafish gills in vivo. Methods: Nasal challenge of adult volunteers was performed with saline, poly IC (n=4), poly ICLC (n=4) or resiquimod (n=8; 5 non-atopic, 3 atopic). Nasal mucosal lining fluid (MLF) was obtained by nasosorption at regular intervals up to 24 hours after challenge; nasal obstruction was monitored by peak nasal inspiratory flow (PNIF) and total nasal symptom scores (TNSS). Cytokines and interferons were measured in MLF using electrochemiluminescence on the Meso Scale Discovery (MSD) platform. Adult zebrafish gills were exposed to the same TLR agonists and gene expression was quantified in gill tissue at similar time-points. Results: Nasal challenge with TLR3 agonists failed to elicit any significant responses when compared to saline. In contrast resiquimod (10μg/100μl per nostril) caused a potent induction of cytokines with an early release (1-3 hours) of IFN-α2a, TNF-α and IL-1β and a later release (after 4 hours) of IFN-γ. The 3 volunteers with the highest levels of IFN-α2a were atopic. Six volunteers were asymptomatic and two volunteers had flu-like symptoms. There were no significant changes in clinical correlates of nasal obstruction. After resiquimod administration, but not TLR3 agonists, zebrafish gills showed an immune profile remarkably analogous to human nasal responses. Conclusion: The TLR7/8 agonist resiquimod is a potent mucosal inducer of IFN-α2a, IFN-γ and proinflammatory cytokines, whilst TLR3 agonists failed to stimulate mucosal innate immune responses. Zebrafish gills accurately mimic human nasal mucosal responses following exposure to TLR agonists, offering translational app

CONFERENCE PAPER

Wolsk HM, Folsgaard NV, Birch S, Brix S, Hansel TT, Johnston SL, Kebadze T, Chawes BL, Bonnelykke K, Bisgaard Het al., 2016, Picornavirus-Induced Airway Mucosa Immune Profile in Asymptomatic Neonates, JOURNAL OF INFECTIOUS DISEASES, Vol: 213, Pages: 1262-1270, ISSN: 0022-1899

JOURNAL ARTICLE

Gunawardana NC, Campbell G, Lindsley S, Mann EE, Openshaw PJM, Johnston SL, Hawrylowicz CM, Hansel TTet al., 2016, The Effect of Vitamin D Supplementation on Mucosal IL-5, MMP9 and Cathelicidin after Nasal Allergen Challenge with Grass Pollen, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB73-AB73, ISSN: 0091-6749

CONFERENCE PAPER

Dhariwal J, Cameron A, Trujillo-Torralbo B, Del Rosario A, Paulsen M, Jackson DJ, Edwards MR, Cousins D, Hansel TT, Johnston SL, Walton RPet al., 2016, Novel Nasal Sampling Techniques Identify Ilc2s As Important Responders In Asthma During Nasal Allergen Challenge, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

Barnes PJ, Burney PGJ, Silverman EK, Celli BR, Vestbo J, Wedzicha JA, Wouters EFMet al., 2015, Chronic obstructive pulmonary disease, Publisher: NATURE PUBLISHING GROUP

BOOK

Abbara A, Buell KG, Sullivan JAL, Collin SM, Kon OM, Hansel T, John L, Davidson RNet al., 2015, TUBERCULOSIS IN OLDER VERSUS YOUNGER ADULT PATIENTS: A RETROSPECTIVE COMPARISON OF PATIENT CHARACTERISTICS AND TREATMENT OUTCOMES AT A MAJOR UK REFERRAL CENTRE, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A203-A203, ISSN: 0040-6376

CONFERENCE PAPER

Abbara A, Lang S, Kon OM, Collin SM, Pan D, Hansel T, Ravindran R, Holder R, John L, Davidson RNet al., 2015, WEEKLY AUDIOGRAMS PRE-EMPTIVELY IDENTIFY AMIKACIN RELATED OTOTOXICITY IN MDR-TB, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A25-A25, ISSN: 0040-6376

CONFERENCE PAPER

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