Professor Trevor Hansel

Kon OM, Hansel TT, Barnes PJ, 2008, Chronic Obstructive Pulmonary Disease, Great Britain, Publisher: Oxford University Press

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Pettipher R, Hansel TT, 2008, Antagonists of the Prostaglandin D₂ Receptor CRTH2, DRUG NEWS & PERSPECTIVES, Vol: 21, Pages: 317-322, ISSN: 0214-0934

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• Citations: 33

Flood-Page P, Swenson C, Faiferman I, Matthews J, Williams M, Brannick L, Robinson D, Wenzel S, Busse W, Hansel TT, Barnes NCet al., 2007, A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 176, Pages: 1062-1071, ISSN: 1073-449X

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• Citations: 573

Pettipher R, Hansel TT, Armer R, 2007, Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases., Nat Rev Drug Discov, Vol: 6, Pages: 313-325, ISSN: 1474-1776

Immunological activation of mast cells is an important trigger in the cascade of inflammatory events leading to the manifestation of allergic diseases. Pharmacological studies using the recently discovered DP(1) and CRTH2 antagonists combined with genetic analysis support the view that these receptors have a pivotal role in mediating aspects of allergic diseases that are resistant to current therapy. This Review focuses on the emerging roles that DP(1) and CRTH2 (also known as DP(2)) have in acute and chronic aspects of allergic diseases and proposes that, rather than having opposing actions, these receptors have complementary roles in the initiation and maintenance of the allergy state. We also discuss recent progress in the discovery and development of selective antagonists of these receptors.

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Hopkinson NS, Tennant RC, Dayer MJ, Swallow EB, Hansel TT, Moxham J, Polkey MIet al., 2007, A prospective study of decline in fat free mass and skeletal muscle strength in chronic obstructive pulmonary disease, RESPIRATORY RESEARCH, Vol: 8, ISSN: 1465-9921

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• Citations: 131

Erin EM, Onn MK, Barnes PJ, Hansel TTet al., 2007, From the authors [2], American Journal of Respiratory and Critical Care Medicine, Vol: 175, Pages: 288-289, ISSN: 1073-449X

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Erin EM, Onn MK, Barnes PJ, Hansel TTet al., 2007, From the authors [2], American Journal of Respiratory and Critical Care Medicine, Vol: 175, Pages: 196-197, ISSN: 1073-449X

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Nicholson GC, Tennant RC, Carpenter DC, Sarau HM, Kon OM, Barnes PJ, Salmon M, Vessey RS, Tal-Singer RT, Hansel TTet al., 2007, A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels: upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonist, Pulmonary Pharmacology and Therapeutics, Vol: 20, Pages: 52-59, ISSN: 1094-5539

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Erin EM, Leaker BR, Nicholson GC, Tan AJ, Green LM, Neighbour H, Zacharasiewicz AS, Turner J, Barnathan ES, Kon OM, Barnes PJ, Hansel TTet al., 2006, The effects of a monoclonal antibody directed against tumor necrosis factor-α in asthma (Retracted article. See vol. 183, pg. 418, 2011), AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 174, Pages: 753-762, ISSN: 1073-449X

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• Citations: 220

Hansel TT, Benezet O, Kafe H, Ponitz H-H, Cheung D, Engelstaetter R, Barnes PJet al., 2006, A multinational, 12-week, randomized study comparing the efficacy and tolerability of ciclesonide and budesonide in patients with asthma, CLINICAL THERAPEUTICS, Vol: 28, Pages: 906-920, ISSN: 0149-2918

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• Citations: 35

Erin EM, Leaker BR, Zacharasiewicz A, Higgins LA, Nicholson GC, Boyce MJ, de Boer P, Jones RC, Durham SR, Barnes PJ, Hansel TTet al., 2006, Effects of a reversible β-tryptase and trypsin inhibitor (RWJ-58643) on nasal allergic responses, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 36, Pages: 458-464, ISSN: 0954-7894

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• Citations: 32

Gamble E, Qiu Y, Wang D, Zhu J, Vignola AM, Kroegel C, Morell F, Hansel TT, Pavord ID, Rabe KF, Barnes NC, Jeffery PKet al., 2006, Variability of bronchial inflammation in chronic obstructive pulmonary disease: implications for study design, EUROPEAN RESPIRATORY JOURNAL, Vol: 27, Pages: 293-299, ISSN: 0903-1936

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• Citations: 30

Erin EM, Leaker BR, Zacharasiewicz AS, Higgins LA, Nicholson GC, Boyce MJ, de Boer P, Jones RC, Durham SR, Barnes PJ, Hansel TTet al., 2006, Effects of a reversible beta-tryptase and trypsin inhibitor (RWJ-58643) on nasal allergic responses, Clinical and Experimental Allergy, Vol: 36, Pages: 458-464, ISSN: 0954-7894

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Hansel TT, Neighbour H, Erin EM, Tan AJ, Tennant RC, Mans JG, Barnes PJet al., 2005, Glycopyrrolate causes prolonged bronchoprotection and bronchodilatation in patients with asthma, CHEST, Vol: 128, Pages: 1974-1979, ISSN: 0012-3692

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• Citations: 59

Erin EM, Neighbour H, Tan AJ, Kon OM, Durham SR, Hansel TTet al., 2005, Nasal testing for novel anti-inflammatory agents, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 35, Pages: 981-985, ISSN: 0954-7894

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• Citations: 2

Zacharasiewicz A, Wilson N, Lex C, Erin EM, Li AM, Hansel T, Khan M, Bush Aet al., 2005, Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 171, Pages: 1077-1082, ISSN: 1073-449X

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• Citations: 255

Lex C, Payne DNR, Zacharasiewicz A, Li AM, Wilson NM, Hansel TT, Bush Aet al., 2005, Sputum induction in children with difficult asthma: Safety, feasibility, and inflammatory cell pattern, PEDIATRIC PULMONOLOGY, Vol: 39, Pages: 318-324, ISSN: 8755-6863

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• Citations: 76

Erin EM, Leaker BR, Zacharasiewicz AS, Higgins LA, Williams TJ, Boyce MJ, de Boer P, Durham SR, Barnes PJ, Hansel TTet al., 2005, Single dose topical coticosteroid inhibits IL-5 and IL-13 in nasal lavage following grass pollen challenge., Allergy, Vol: 60, Pages: 1524-1529

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Erin EM, Zacharasiewicz AS, Nicholson GC, Tan AJ, Higgins LA, Williams TJ, Murdoch RD, Durham SD, Barnes PJ, Hansel TTet al., 2005, Topical corticosteroid inhibits IL-4, IL-5 and IL-13 in nasal secretions following allergen challenge, Clinical and Experimental Allergy, Vol: 35, Pages: 1608-1614

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Hansel T, Biberger C, Engelstätter R, 2004, Ciclesonide 80 μG or 320 μG once daily achieves lung function improvement comparable with budesonide 200 μG twice daily in patients with persistent asthma, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 71-71, ISSN: 0040-6376

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• Citations: 2

Hansel TT, 2004, How do we measure the effectiveness of inhaled corticosteroids in clinical studies?, Respir Med, Vol: 98 Suppl B, Pages: S9-15, ISSN: 0954-6111

Inhaled corticosteroids (ICSs) are the gold standard anti-inflammatory therapy for asthma and have been studied using a variety of different clinical trial designs. In long-term comparative studies ICSs are more effective in controlling asthma than beta-agonists or leukotriene antagonists (LTAs). Efficacy has also been shown retrospectively, as patients frequently experience an exacerbation of their asthma upon withdrawal of ICSs, whilst the regular use of low dose ICSs prevents death from asthma. The combination of ICSs with long-acting beta2-agonists (LABAs) is effective for patients with asthma non-responsive to low doses of ICSs, particularly in reducing exacerbations. In shorter term studies a modest dose-response effect of ICSs has been shown for lung function, symptom control and oral corticosteroid use in asthmatic patients. ICSs are also effective in reducing airway hyperresponsiveness (AHR) to various stimuli, as well as reducing exhaled nitric oxide (NO) concentrations and the number and activation state of a wide variety of inflammatory cells. Finally, using allergen challenge models even single doses of ICSs have profound inhibitory effects on the late asthmatic reaction. Since ICSs are the mainstay of asthma management guidelines, it is important that novel therapies should be judged against ICSs in future clinical trials. There are many potential designs for these comparative studies.

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Barnes PJ, Hansel TT, 2004, Prospects for new drugs for chronic obstructive pulmonary disease, LANCET, Vol: 364, Pages: 985-996, ISSN: 0140-6736

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• Citations: 142

Leckie MJ, Gomma AH, Purcell IF, Nyawo B, Dewar A, Orkongly D, Burman JF, Hooper J, Barnes PJ, Clague JR, Hansel TTet al., 2004, Automated quantitation of peripheral blood neutrophil activation in patients with myocardial ischaemia, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 95, Pages: 307-313, ISSN: 0167-5273

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• Citations: 9

Hansel TT, Tennant RC, Tan AJ, Higgins LA, Neighbour H, Erin EM, Barnes PJet al., 2004, Theophylline: Mechanism of action and use in asthma and chronic obstructive pulmonary disease, DRUGS OF TODAY, Vol: 40, Pages: 55-69, ISSN: 1699-3993

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• Citations: 38

Hansel TT, Barnes PJ, 2004, An Atlas of Chronic Obstructive Pulmonary Disease, London, Publisher: Parthernon Publishing, ISBN: 9781842140048

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Hansel TT, Tennant RC, Erin EM, Tan AJ, Barnes PJet al., 2004, New drugs for COPD based on advances in pathology, Recent Advances in the Pathophysiology of COPD. Progress in Inflammation Research, Basel, Boston, Berlin, Publisher: Birkhauser

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Barnes PJ, Erin EM, Hansel TT, Kharitonov S, Tan AJ, Tennant RCet al., 2004, Evaluation of New Drugs for Asthma and COPD: Endpoints, Biomarkers and Clinical Trial Designs, Pharmacology and Therapeutics of Asthma and COPD, Heidelberg, Publisher: Springer-Verlag

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Tennant RC, Hansel TT, Hansell DM, 2004, Computed tomography (CT) scans in COPD, Recent Advances in the Pathophysiolgy of COPD. Progress in Inflammatory Research., Basel, Boston, Berlin, Publisher: Birkhauser

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Hansel T, 2004, Recent Advances in the Pathophysiology of COPD. Progress in Inflammation Research., Basel, Boston, Berlin, Publisher: Birkhauser

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Li AM, Lex C, Zacharasiewicz A, Wong E, Erin E, Hansel T, Wilson NM, Bush Aet al., 2003, Cough frequency in children with stable asthma: correlation with lung function, exhaled nitric oxide, and sputum eosinophil count, THORAX, Vol: 58, Pages: 974-978, ISSN: 0040-6376

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• Citations: 25