Imperial College London
Alternate

DrTamiKramer

Faculty of Medicine, Faculty of Medicine Centre

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 4161t.kramer

 
 
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Assistant

 

Ms Nicole Hickey +44 (0)20 3313 4161

 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Als:2016:10.1007/s00787-016-0933-3,
author = {Als, L and Picouto, MD and O'Donnell, KJ and Nadel, S and Cooper, M and Pierce, CM and Kramer, T and Glover, V and Garralda, Hualde ME},
doi = {10.1007/s00787-016-0933-3},
journal = {European Child & Adolescent Psychiatry},
pages = {511--5119},
title = {Stress hormones and posttraumatic stress symptoms following paediatric critical illness: an exploratory sudy},
url = {http://dx.doi.org/10.1007/s00787-016-0933-3},
volume = {26},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In this exploratory case-control study we investigatedbasalcortisol regulation in 5-16 year-old children, 3-6 months following PICU (paediatric intensive care) admission.Thiswas nested within a study of child psychological and cognitivefunction; 47 children were assessed alongside 56 healthy controls. Saliva samples were collected three times per day (immediately after waking, waking +30min, and waking +12h)over two consecutive weekdays. In addition, data on posttraumatic stress symptoms were ascertained from 33 PICU admitted children using the Impact of Events Scale-8(IES-8).Primary analysis revealed no significantdifferences in basal cortisol concentrations between PICU discharged children and healthy controls (p > 0.05). Secondary analysis in the PICU group identifieda significant positive association between posttraumatic stress symptoms and evening (waking+12h) cortisol concentrations (p = 0.004). However when subject to multivariate analysis,evening cortisol was a modest independent predictor of IES-8 scores, relative to the presence of septic illness and poor pre-morbid health.We conclude that paediatric critical illness does not appear toresult in marked perturbations to basal cortisol at 3-6 monthfollowing discharge. There was evidence of a link between evening cortisol and symptoms of PTSD, but this was not a robust effectandrequiresfurther elucidation.
AU  - Als,L
AU  - Picouto,MD
AU  - O'Donnell,KJ
AU  - Nadel,S
AU  - Cooper,M
AU  - Pierce,CM
AU  - Kramer,T
AU  - Glover,V
AU  - Garralda,Hualde ME
DO  - 10.1007/s00787-016-0933-3
EP  - 5119
PY  - 2016///
SN  - 1435-165X
SP  - 511
TI  - Stress hormones and posttraumatic stress symptoms following paediatric critical illness: an exploratory sudy
T2  - European Child & Adolescent Psychiatry
UR  - http://dx.doi.org/10.1007/s00787-016-0933-3
UR  - http://hdl.handle.net/10044/1/43083
VL  - 26
ER  -
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